Hand hygiene, specifically cleaning hands before touching patients, is the most important way to prevent the spread of infections in healthcare settings. The WHO recommends cleaning hands at 5 key moments: before touching a patient, before clean procedures, after body fluid exposure, after touching a patient, and after contact with surfaces near the patient. Alcohol-based handrubs are more effective at killing germs than soap and water, take less time, and are less damaging to skin. Proper hand hygiene, including using alcohol-based handrubs, can significantly reduce healthcare-associated infections.