Hemolytic anemia

Hemolytic anemia

• 1.
  Hemolytic anemia Dr . T.Arivazhagan Departmentof pathology
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  Introduction • Hemolytic anemiasare the anemias in which there is increased red cell destruction. • Anemia develops due to inability of the bone marrow to compensate for the degree of destruction. • Normal life span 120 days • In hemolytic anemia become as low as 15 days • If compensatory marrow regeneration is adequate patient will not manifest the anemia.
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  Red cell destruction 1.Extra vascular • Spleen – 80 -90% 2. Intravascular • Destruction of RBC’s in the blood vessels itself
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  Clinical features 1. Pallor 2.Jaundice 3. Splenomegaly 4. Gall stone 5. Skeletal abnormalities 6. Ulcers
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  Peripheral smear 1. Polychromatophilic 2.Nucleated RBCS 3. Spherocytes 4. Sickle cells 5. Target cells 6. schistocytes
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  Bone marrow 1. Erythroidhyperplasia 2. Reticulocytosis