Downloaded 48 times
More Related Content
More from Drx Mathivanan Selvam
Heterocyclic compound thiazole
- 1. Heterocyclic compound- Thiazole Lectureby S.Mathivanan.,M.Pharm Asst Professor Pharmacy
- 2. Thiazole nucleus isa heterocyclic organic compound bearing both sulfur and nitrogen atom at 1,3 position with five-member heterocyclic ring
- 3. • Thiazole moleculesused as an intermediate, chemical in synthetic drugs, fungicides and dyes in industries. • A thiazole ring present naturally in the essential vitamin B1 thaimin.
- 4. • Various derivativesof thiazole nucleus is the aim of research due to their importance in various applications. • Derivatives of thiazole heteroatom used as reactants, intermediaries in the various industries like agrochemical, pharmaceutical and the pesticides industry. • Most of the derivatives of thiazole were synthesized to achieve the industrial, biological, and medicinal target by numerous research scholar and scientist in R&D laboratories.
- 5. Molecular and electronicstructure • Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. • This aromaticity is evidenced by the chemical shift of the ring protons in proton NMR spectroscopy (between 7.27 and 8.77 ppm), clearly indicating a strong diamagnetic ring current. • The calculated pi-electron density marks C5 as the primary site for electrophilic substitution, and C2 as the site for nucleophilic substitution.
- 6. Physical properties • Thiazolecompound have a clear to pale yellow liquid. • Odor similar to pyridine and its • Boiling point is 116- 118oC. • The specific gravity of thiazole is 1.2 • Sparingly soluble in water. • Soluble in alcohol and ether.
- 7.
- 8.
- 9.
- 10.
- 11. Synthesis 2. From anα- Hydroxy - Carbonyl Component ( Hantzsch Thiazole Synthesis)
- 12. Synthesis 2. From anα- Hydroxy - Carbonyl Component ( Hantzsch Thiazole Synthesis) Mechanism
- 13. Synthesis 3. From anthiocyanate salts
- 15. Reactions 1. Electrophilic additionto N a. Protonation (basic property)
- 16.
- 17.
- 18.
- 19.
- 20.
- 21.