This document discusses improving the comfort properties of polyester/cotton knit fabrics through chemical and biological treatments. It describes scouring and bleaching a 52% polyester 48% cotton fabric. The fabric was then treated with varying concentrations and durations of caustic soda to modify the polyester fibers, and cellulase enzyme to modify the cotton fibers. Testing found caustic treatment improved air permeability and moisture management by reducing polyester fiber diameter. Cellulase treatment improved surface smoothness by removing protruding cotton fibers. The treatments were effective in enhancing the thermo-physiological comfort of the blended knit fabric.