Dr Mathew Joseph MBBS, MD(AIIMS), BCC(Palliative Medicine)
Assistant Professor
Department of Anatomy
Amala Institute of Medical Sciences
Thrissur
Glands
 A gland is an organ that consists of specialized
secretory cells.
 Secreted material is usually a liquid.
 Epithelial in origin.
 Present in singly or in groups.
 Unicellular or Multicellular
 2 types:
Exocrine
Endocrine
Unicellular Glands
 Single cell distributed among non-secretory cells.
Multicellular Glands
 Formed by invagination of
epithelial layer in deeper
tissue to form a
diverticulum:
 Proximal part forms duct.
 Distal part forms secretory
element.
Exocrine: pour their
secretions onto an
epithelial surface,
directly or through
ducts.
Endocrine (ductless):
pour their secretions
directly into the blood.
Classification of Exocrine glands
 Based on shape & branching pattern of duct
 Based on mode of release of their product
 Based on the nature of their secretion
Classification based on shape & branching
pattern of duct
 Based on shape of secretory units (tubular or alveolar)
& branching pattern of ducts.
 2 types:
Simple Compound
Classification based on shape &
branching pattern of duct
Simple glands
• Simple tubular
• Simple coiled tubular
• Simple branched tubular
• Simple branched alveolar
Compound glands
 Compound tubular
 Compound alveolar
 Compound tubulo-
alveolar
Simple glands


Compound glands
Crypt of Lieberkuhn Sweat glands Fundic glands of stomach Meibomian glands
Brunner glands Submandibular gland Mammary gland
Classification based on mode of secretion
• Merocrine: secretion is released by
exocytosis of secretory granules
(pancreas, parotid gland, protein
component of milk from mammary
gland).
• Apocrine: apical portion of cell along
with secretory product is pinched off
(lipid component of milk from the
mammary gland).
• Holocrine: entire cell is shed along
with secretory product (sebaceous
glands).
Modes of secretion
Merocrine: secretion by
exocytosis
Modes of secretion
• Merocrine: secretion by
exocytosis
• Apocrine: secretion by loss
of cytoplasm
• Holocrine: secretion
through loss of entire cell
Classification based on the nature of
secretion
• Serous glands
• Mucous glands
• Mixed glands
Serous Glands
 Secretion: Thin, watery,
rich in enzymes, protein in
nature.
 Cytoplasm: granular (stain
darkly from pink to dark
purple with H/E stain) &
rich in RER.
 Nuclei: rounded & basally
placed.
Mucous glands
 Secretion: contains
mucopolysaccharides
which collects in the apical
part of cell.
 Cytoplasm: stain very
lightly with H/E stain &
therefore gives empty look.
 Nuclei: basally placed &
flattened (mucoid pushes
the nuclei).
Mixed glands
 Contain both serous &
mucous secretory units.
 Sometimes serous cells
form crescentic caps on
mucous acini called as
serous demilunes.
Major glands
 Lie completely outside
the alimentary tract &
connected to it by an
excretory duct.
 Compound alveolar or
tubuloalveolar in type.
 Parotid, submandibular,
sublingual.
Minor glands
 Small salivary glands situated in the mucous
membrane of:
Lip (labial)
Cheeks (buccal)
Soft palate (palatine)
Tongue (lingual)
Functions of Salivary glands
 Secrete saliva composed of water, mucus, proteins,
salts, salivary amylase (ptyalin), immunoglobulins
(IgA) & lactoperoxidase.
 Serves to moisten food.
 Lubricates & moistens oral mucosa and lip.
 Initiates the digestion of carbohydrates.
Basic organization
Different types of acini
Mucous Serous Mixed
Features of serous & mucous cells
EM
LM
Serous cell Mucous cell
Differences between serous & mucous acini
Differences between serous & mucous cells
Parotid gland
Submandibular gland
Sublingual gland
References
1. diFiore’s Atlas of Histology with functional
Correlations, 12th Edition.
2. Textbook of Human Histology. Inderbir Singh, 1st
Edition.
3. Textbook of Histology. GP Pal, 3rd Edition.
MCQ
1. All are major salivary glands except:
a) Palatine
b) Parotid
c) Submandibular
d) Sublingual
MCQ
2. Holocrine type of secretion is a feature of:
a) Mammary gland
b) Parotid gland
c) Sebaceous gland
d) Pancreas
MCQ
3. Sweat gland is an example of:
a) Simple tubular gland
b) Simple coiled tubular gland
c) Simple branched tubular gland
d) Simple alveolar gland
MCQ
4. All are true about serous acini except:
a) Smaller in size
b) Stain dark
c) May present as demilune
d) Wide lumen
MCQ
5. Expelling of secretion through contraction
is a feature of:
a) Serous cell
b) Mucous cell
c) Serous demilune
d) Myoepithelial cell
Body Cavities & Membranes
Thank You

Histology_glands.pptx

  • 1.
    Dr Mathew JosephMBBS, MD(AIIMS), BCC(Palliative Medicine) Assistant Professor Department of Anatomy Amala Institute of Medical Sciences Thrissur
  • 2.
    Glands  A glandis an organ that consists of specialized secretory cells.  Secreted material is usually a liquid.  Epithelial in origin.  Present in singly or in groups.  Unicellular or Multicellular  2 types: Exocrine Endocrine
  • 3.
    Unicellular Glands  Singlecell distributed among non-secretory cells.
  • 4.
    Multicellular Glands  Formedby invagination of epithelial layer in deeper tissue to form a diverticulum:  Proximal part forms duct.  Distal part forms secretory element.
  • 5.
    Exocrine: pour their secretionsonto an epithelial surface, directly or through ducts. Endocrine (ductless): pour their secretions directly into the blood.
  • 6.
    Classification of Exocrineglands  Based on shape & branching pattern of duct  Based on mode of release of their product  Based on the nature of their secretion
  • 7.
    Classification based onshape & branching pattern of duct  Based on shape of secretory units (tubular or alveolar) & branching pattern of ducts.  2 types: Simple Compound
  • 8.
    Classification based onshape & branching pattern of duct Simple glands • Simple tubular • Simple coiled tubular • Simple branched tubular • Simple branched alveolar Compound glands  Compound tubular  Compound alveolar  Compound tubulo- alveolar
  • 9.
  • 10.
  • 11.
    Crypt of LieberkuhnSweat glands Fundic glands of stomach Meibomian glands Brunner glands Submandibular gland Mammary gland
  • 12.
    Classification based onmode of secretion • Merocrine: secretion is released by exocytosis of secretory granules (pancreas, parotid gland, protein component of milk from mammary gland). • Apocrine: apical portion of cell along with secretory product is pinched off (lipid component of milk from the mammary gland). • Holocrine: entire cell is shed along with secretory product (sebaceous glands).
  • 13.
    Modes of secretion Merocrine:secretion by exocytosis
  • 14.
    Modes of secretion •Merocrine: secretion by exocytosis • Apocrine: secretion by loss of cytoplasm • Holocrine: secretion through loss of entire cell
  • 15.
    Classification based onthe nature of secretion • Serous glands • Mucous glands • Mixed glands
  • 16.
    Serous Glands  Secretion:Thin, watery, rich in enzymes, protein in nature.  Cytoplasm: granular (stain darkly from pink to dark purple with H/E stain) & rich in RER.  Nuclei: rounded & basally placed.
  • 17.
    Mucous glands  Secretion:contains mucopolysaccharides which collects in the apical part of cell.  Cytoplasm: stain very lightly with H/E stain & therefore gives empty look.  Nuclei: basally placed & flattened (mucoid pushes the nuclei).
  • 18.
    Mixed glands  Containboth serous & mucous secretory units.  Sometimes serous cells form crescentic caps on mucous acini called as serous demilunes.
  • 21.
    Major glands  Liecompletely outside the alimentary tract & connected to it by an excretory duct.  Compound alveolar or tubuloalveolar in type.  Parotid, submandibular, sublingual.
  • 22.
    Minor glands  Smallsalivary glands situated in the mucous membrane of: Lip (labial) Cheeks (buccal) Soft palate (palatine) Tongue (lingual)
  • 23.
    Functions of Salivaryglands  Secrete saliva composed of water, mucus, proteins, salts, salivary amylase (ptyalin), immunoglobulins (IgA) & lactoperoxidase.  Serves to moisten food.  Lubricates & moistens oral mucosa and lip.  Initiates the digestion of carbohydrates.
  • 24.
  • 25.
    Different types ofacini Mucous Serous Mixed
  • 26.
    Features of serous& mucous cells EM LM Serous cell Mucous cell
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.
  • 34.
    References 1. diFiore’s Atlasof Histology with functional Correlations, 12th Edition. 2. Textbook of Human Histology. Inderbir Singh, 1st Edition. 3. Textbook of Histology. GP Pal, 3rd Edition.
  • 35.
    MCQ 1. All aremajor salivary glands except: a) Palatine b) Parotid c) Submandibular d) Sublingual
  • 36.
    MCQ 2. Holocrine typeof secretion is a feature of: a) Mammary gland b) Parotid gland c) Sebaceous gland d) Pancreas
  • 37.
    MCQ 3. Sweat glandis an example of: a) Simple tubular gland b) Simple coiled tubular gland c) Simple branched tubular gland d) Simple alveolar gland
  • 38.
    MCQ 4. All aretrue about serous acini except: a) Smaller in size b) Stain dark c) May present as demilune d) Wide lumen
  • 39.
    MCQ 5. Expelling ofsecretion through contraction is a feature of: a) Serous cell b) Mucous cell c) Serous demilune d) Myoepithelial cell
  • 40.
    Body Cavities &Membranes
  • 53.