This document discusses various aspects of research design and methodology. It addresses how to properly frame research questions, select appropriate sampling strategies, and consider challenges that may arise. Specific examples are provided on framing research on public-private partnerships in education, remedial teacher education, and the impact of a schooling program. Key points covered include how to minimize sampling error through randomization, representativeness, and accounting for clustering. The importance of statistical power in hypothesis testing and detecting real effects is also emphasized.