Immunogenetics m phil 30 12-14
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This document provides an overview of immunogenetics and immune disorders. It discusses the organization of the immune system, innate and adaptive immunity, B and T cells, memory cells, macrophages, complement proteins, cytokines, immunoglobulins, genetics of antibody formation, class switching, antibody-mediated diseases, immune complex diseases, T cell-mediated diseases, HLA-associated diseases, and deficiency diseases. The goal is for students to understand the immune system and disorders related to breakdowns in immune function.
Immunogenetics m phil 30 12-14
- 2. Learning Objectives • By the end of this lecture……….we all should be able: – To appreciate the organization of immune system – Understand the disorders related to immune system – Explain the underlying mechanisms of immune disorders
- 4. Role of immune system and their applications
- 5. Innate and Adaptive imunity
- 6. Primary and Secondary Response
- 7. B and T Cells
- 8. Memory Cells
- 11. Cytokines
- 12. Cytokines
- 13. Immunoglobulins • Papaine splits the immunoglobulin molecule into three fragments. – Two similar, each containing an antibody site capable of combining with a specific antigen antigen- binding fragment or Fab – The Crystallizable fragment Fc The immunoglobulin molecule is made up of four polypeptide chains: •Two light(L) 220 AA •Two heavy (H) 440 AA Each Fab fragment is composed of L chains linked to the amino-terminal portion of the H chains, Fc fragment is composed only of the carboxv-terminal portion of the H chain
- 14. Immunoglobulins
- 15. Immunoglobulins
- 16. A Closer look at structure
- 17. Genetics of antibody formation Basis of Diversity
- 18. Genetics of Antibody formation A closer look
- 19. Class switching
- 22. T Cell Mediated Diseases
- 23. HLA Associated Diseases Locus of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans.
- 25. Thank you!