Important Synthesis of Antiviral Drugs

Important Synthesis of Antiviral Drugs

• 1.
  IMPORTANT SYNTHESIS OF ANTI-VIRALDRUGS Presented By:-Dr. Anjali Bhardwaj
• 3.
  Synthesis of Acyclovir
• 5.
  Uses:- -Acyclovir is usedto treat infections caused by certain types of viruses. -It treats cold sores around the mouth (caused by herpes simplex), shingles (caused by herpes zoster), and chickenpox. -This medication is also used to treat outbreaks of genital herpes. Brand Name-Zovirax, ACLOVIR DT, ALOVIR 200
• 6.
  Synthesis of Ganciclovir
• 8.
  Ganciclovir is ananti-viral drug. It is used to prevent disease caused by a virus called cytomegalovirus (CMV) in people who have received organ or bone marrow transplants. Adverse Effect CMV disease can lead to serious infections in the body, including an infection in the eye, called CMV retinitis, that can cause blindness. Brand Name-Cytovene, Cytovene IV
• 9.
  Synthesis of Idoxuridine
• 10.
  Mechanism of actionof Idoxuridine -Idoxuridine is phosphorylated by thymidine kinase in host cell to convert into active triphosphate form which is closely resembles thymidine. It inhibits thymidylic phosphorylase and specific DNA polymerases, which are necessary for the incorporation of thymidine into viral DNA. Idoxuridine is incorporated in place of thymidine into viral DNA, resulting in faulty DNA and the
• 11.
  Idoxuridine ophthalmic isan antiviral medication. It prevents the replication (reproduction) of the herpes simplex virus. Thus, it reduces the amount of active virus in your system. Idoxuridine ophthalmic is used to treat eye infections caused by
• 12.
  Synthesis of Methisazone
• 13.
  Mechanism of Action- Methisazoneinterfere with the translation mRNA messages into protein synthesis on the cell ribosomes, resulting defect in protein inclusion into the virus. Brand Name:-Marboran
• 14.
  Synthesis of Amantadine BrandName:-Symmetrel, Gocovri, Osmolex ER Use-It is used to treat and prevent respiratory infections caused by the influenza A virus. It can also treat symptoms of Parkinson's disease
• 15.
  The mechanism of Amantadine'santiviral activity involves interference with a viral protein M2 (an ion channel), which is required for the viral particle to become "uncoated" once taken inside a cell by endocytosis.Influenza B does not possess M2 channels, and thus the drug is ineffective towards all Influenza B strains. • Amantadine has been associated with several central nervous system side effects. CNS side effects include nervousness, anxiety, agitation, insomnia and difficulty in
• 16.
  Synthesis of Rimantadine
• 17.
  Mechanism of Actionof Rimantadine It produce antiviral effect against influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the uncoating of the virus and subsequent release of infectious viral nucleic acids into the cytoplasm of infected cells. Use: Rimantadine is used to prevent or treat a certain type of flu virus (influenza A) Brand Name:-Flumadine
• 19.
  Synthesis of Ribavirin
• 20.
  It is aguanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, thus, it is a nucleoside inhibitor. Ribavirin is a prodrug, which when metabolized resembles purine RNA nucleotides. In this form, it interferes with RNA metabolism required for viral replication.Ribavirin is used in combination with other antiviral medications (such as interferon, sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Brand Name:-Rebetol, Ribasphere, RibaPak,
• 21.
  Presented By Dr.Anjali Bhardwaj Upcoming Topics are -Mechanism of Action of Other Anti- Viral -Anti-Hiv Drugs