Infection control for_hemodialysis_facilities

Infection control for
Hemodialysis Facilities
Mohamed Dahab, MD
Specialist of nephrology, UNC

Introduction
• Hemodialysis (HD) patients are uniquely vulnerable to the development of
healthcare-associated infections because of multiple factors including
exposure to invasive devices, immunosuppression, the lack of physical
barriers between patients in the outpatient hemodialysis environment,
and frequent contact with healthcare workers during procedures and care.
• 2012 USRDS annual report noted that progression in lowering the rate of
infectious complications among hemodialysis facilities is lacking and the
use of hemodialysis catheters continues to be the largest associated risk.
• Canadian study found that effective infection control program offers a
double benefit-saving money while simultaneously improving the quality
of care (Hong et al., 2010).

Environmental Cleaning/Disinfection
• cleaning of environmental surfaces using
detergent (soap), water, and friction is the
critical step required prior to surface
disinfection
• Disinfection will not be effective in the
presence of dirt.
• Disinfectant for blood contaminated
environmental surfaces is a 1:100 dilution of
bleach

The CDC’s Guideline for Disinfection and Sterilization in Healthcare
Facilities,2008, states that:
Non critical surfaces (e.g., dialysis bed or chair, countertops, external surfaces of dialysis
machines) should be disinfected with an EPA-registered disinfectant unless the item is visibly
contaminated with blood. In that case, an EPA registered tuberculocidal agent with specific
label claims for HBV and HIV should be used. One commonly used disinfectant for blood
contaminated environmental surfaces is a 1:100 dilution of bleach.
Micro-organisms can live for varying periods of time in the
environment. MRSA has been documented as viable at 38 weeks on
external sterile packaging and VRE at 6 months on a wheelchair. HBV
can survive for 7 days in dried blood.

Equipment Cleaning/Disinfection
• Exterior Cleaning and Disinfection of Dialysis
Machine
• Interior Disinfection of Dialysis Machine
• Monitoring Dialysis Machine Disinfection
• Auxiliary Equipment
• Reprocessing and Reuse of Hemodialyzer

• Hand hygiene is the single most important intervention in preventing
infections in healthcare.
• use of alcohol-based hand sanitizer with an alcohol concentration of
greater than 60% is preferred over hand washing with soap and water.
• Fingernails should be kept short and clean
• Artificial nails are prohibited for direct patient care providers
• Patients must also be instructed for hand hygiene including before and
after dialysis sessions
• Glove use is an integral aspect of hand hygiene
Hand Hygiene

Patient Immunizations and TB Screening
• Tetanus: a dose of dT should be given every 10 years
• Pneumovax: an initial dose should be given when the diagnosis of
CKD is made; a single booster should be given 5 years to complete
the lifetime series.
• Influenza: yearly immunization is required
• Shingles: all dialysis patients over 60 should be evaluated for
Zostavax
• HBV: full series of three vaccinations.
• TB Screening: CDC recommends that all HD patients be screened for
TB at baseline and whenever exposure is suspected. Screening can be
by tuberculin skin test or blood test

Patients should receive HBV vaccine in the pre-dialysis phase when the immune response is
better preserved.
In the case of failure of the patient to reach the desired titer of antibody (≥10 mIU/mL), a
repeated course is recommended. If the patient still does not respond, No additional doses
of vaccine are warranted for those who do not respond to a full second series.
HD centers must be careful not to send blood for testing for HBs Ag within 2–3 weeks of HBV
vaccine administration, as during this time HBs Ag may be detected.
Patients who do achieve the anti-HBs level ≥10 mIU/mL should be screened annually. If the
anti-HBs level ˂ 10 mIU/mL, the patient should be given a booster dose. Patients who are
both anti-HBs and anti-HBc positive do not require such follow-up screening.

Medication Safety and Injection Practices

Patient and Employee Education
CDC 2001 “Infection Control Training and Education”
www.dialysispatients.org/resources.
clinical HD technician certification

Standard Precautions
PPE Guidelines for Standard Precautions in HD Settings
Patients
• Wear a mask during initiation and discontinuation of
dialysis treatment if vascular access is a catheter.
• Wear a mask in an HD facility when experiencing
symptoms of an upper respiratory illness.

• Employees
Lab-style cover coats:
• Regular cotton, non-fluid resistant lab coats are not considered PPE and should be removed
or worn under
• an isolation or fluid resistant gown when needed.
• Fluid resistant lab coats are considered PPE.
• Either type of lab coat must be removed if it becomes soiled or wet.
• Either type of lab coat must be removed prior to leaving the unit and for breaks and lunch.
Full isolation or fluid resistant gowns :
• Be worn when caring for an isolation patient with HBV.
• Cover arms and be closed in front.
• Be worn when there is likelihood of blood contact, especially when initiating and removing
patients from
• dialysis.
• Be worn when there is a likelihood of body fluid contact especially with diarrheal illnesses,
uncontrolled
• secretions, draining wounds, stool incontinence.
• Be worn during reprocessing of dialyzers.

Gloves :
• Worn whenever caring for a patient.
• Worn when touching the patient’s medical equipment or handling lab specimens or
used dialyzers.
• Worn when cleaning machines, cleaning stations, or wiping up blood or other body
fluid spills.
• Changed whenever moving from one patient or machine to another.
• Changed when moving from a dirty to a clean site/task on the same patient
• Changed after cannulation.
• Removal of gloves should always be followed with hand hygiene.
Mask :
• Worn if experiencing mild cold or cough illness in order to protect patients and
other employees.
Face protection :
• Worn during initiation and discontinuation of dialysis.
• Worn during reprocessing dialyzers or cleaning equipment in a sink.
• Worn when within 6 feet of an unmasked coughing patient.
• Discarded between patients or if reusable, cleaned and disinfected between uses
as indicated.

Transmission-Based Precautions
Airborne Precautions: Transmissible airborne illnesses include varicella,
disseminated varicella, TB, and measles. Microorganisms can remain airborne for
up to 2 hours: Patient identified with a suspected airborne disease should be masked immediately
and geographically separated from other patients, preferably in a single room.
Droplet Precautions: Illnesses transmitted by large respiratory droplets include
pertussis, influenza, mumps, strep throat, rubella, diphtheria, Mycoplasma
pneumonia, adenovirus, Neisseria meningitidis, Haemophilus influenzae type b,
and acute respiratory infections with MRSA/VRE/other MDRO: Respiratory
Hygiene/Cough Etiquette Precautions should be followed. If hospitalization is required, the patient
should be spatially separated by at least 6 feet from other patients and a mask worn until transport
can be arranged
Contact Precautions: Illnesses transmitted via contact include C. difficile,
adenovirus, rotavirus, impetigo, scabies, pediculosis, and MDROs (e.g., MRSA, VRE,
and other MDROs): Routine contact precautions are not required in HD units for patients infected
or colonized with pathogenic bacteria.

HBV Isolation/Precautions
• Why isolation???
Environmental stability up to 7 days.
High viral titer.
• Precautions:
Patients are placed in a private room or segregated area.
Dedicated dialysis machine is used for HBV-positive patients.
Dialyzers are discarded in biomedical waste after treatment.
Dialyzers can not be reused.
Gown and gloves are required for each entry into room.
Mask with eye protection is required for cannulation and decannulation.
Staff caring for HBV patients cannot care for HBV susceptible patients
Staff should be HBV-immune.
Required when the HBsAg is +ve and not required when the HBsAg is not -ve .

HIV Positive Patients:
• do not have to be isolated from other patients or dialyzed separately on
dedicated machines.
• can participate in dialyzer reuse programs.
HCV Positive Patients
• do not have to be isolated from other patients or dialyzed separately on
dedicated machines.
• dialyzers can be reused (for same patient) with HCV infection
• The CDC and KDOQI recommends screening HD patients for anti-HCV at 6-month
intervals

Respiratory Hygiene/Cough Etiquette
• Cover the nose/mouth when coughing or sneezing with tissues or
masks to contain respiratory secretions and dispose of them in the
nearest waste receptacle after use.
• Persons unable or unwilling to use tissue or wear a mask should be
separated from others by at least 6 feet.
• HCWs who have a respiratory illness should don a mask with eye
protection when within 6 feet of the individual (microorganism
contact with conjunctiva can cause illness).
• Patients and HCWs should perform hand hygiene after having
contact with respiratory secretions and contaminated
objects/materials.

Vascular Access—Infection Prevention
During Insertion
Catheter Insertion
• Hand hygiene should be performed prior to insertion using either an alcohol-based
hand sanitizer (i.e., gels, wipes, or foams with an alcohol concentration of greater
than 60%) or antimicrobial soap and water.
• Use of the femoral vein should be avoided in adults.
• Maximal sterile barrier precautions (including mask, cap, sterile gown, and sterile
gloves) should be used by the catheter inserter.
• The patient should be covered with a large sterile drape.
• For patients older than 2 months, a skin preparation solution containing greater
than 0.5% chlorhexidine gluconate and 70% isopropyl alcohol should be applied to
the insertion site and allowed to dry before the skin is punctured.

Vascular Access—Infection Prevention
During Care

Exit-Site Dressings and Ointment
• The use of a dry dressing or a transparent dressing
seems to give equal results in preventing exit-site
infection.
• published guidelines recommend changing the dressing
every 3 days for gauze and every 7 days for transparent.
• CDC in 2002 recommend that povidone-iodine antiseptic
ointment be used at the HD catheter exit site after
catheter insertion and at the end of each dialysis session
if this ointment does not interact with the material of the
HD catheter.

Permanent Access: Fistulas/Grafts
The following principles support reduction of infection risk and should be included in
education for dialysis staff and patients.
• Patients with a fistula should be taught fistula exercises to encourage fistula
development. The sooner the fistula develops, the fewer days of infection risk for
the patient who may also have a noncuff ed HD catheter.
• The skin around the access area should be kept clean and dry. Once dialysis is
started, the fistula or graft must be cleansed with soap and water prior to each
dialysis treatment.
• Patients should be encouraged to check the access daily, especially feeling for
presence of a “thrill.
• Tight clothes or jewelry should not be worn in the access arm.
• Sleeping on the access arm should be avoided.
• Taking blood pressure, drawing blood, or putting IVs in the access arm should be
prohibited.
• Lifting heavy objects or putting pressure on the access arm should be avoided.

Skin Preparation Technique for Subcutaneous Arteriovenous Accesses
• Locate, inspect, and palpate the needle cannulation sites prior to skin preparation. Repeat preparation if
the skin is touched by the patient or staff once the skin preparation has been applied, but the cannulation
not completed.
• Wash access site using an antibacterial soap or scrub and water.
• Cleanse the skin by applying CHG greater than 0.5% /70% isopropyl alcohol or 70% alcohol and/or 10%
povidone-iodine .
Notes:
• 0.5% CHG/70% isopropyl alcohol has a rapid and persistent antimicrobial activity on the skin. Higher
concentrations of CHG have demonstrated persistence on the skin of up to seven days. Apply the solution
using back and forth friction scrub per manufacturer’s instructions. Allow the area to dry. Do not blot the
solution.
• Alcohol has a short bacteriostatic action time and should be applied in a rubbing motion for 1 minute
immediately prior to needle cannulation.
• Povidone-iodine needs to be applied 2–3 minutes for its full bacteriostatic action to take effect and must
be allowed to dry prior to needle cannulation.
• Clean gloves should be worn by the dialysis staff for cannulation. Gloved should be changed if
contaminated at any time during the cannulation procedure.
• New, clean gloves should be worn by the dialysis staff for each patient with proper infection control
measures followed between each patient.
Source: 2006 KDQOI recommendations

Surveillance has been defined as the ongoing, systematic collection, analysis,
interpretation, and dissemination of data regarding health-associated events
and is used to reduce morbidity and mortality and to improve health.
Surveillance involves process measures and/or outcome measures Major
components of a healthcare-associated infection surveillance system include
the following :
• Standardized definitions
• Monitoring of population at risk for infection
• Statistical analysis
• Feedback of results to primary caregivers
• Feedback to managers and senior leadership
Surveillance Methodology for Dialysis
Infections

Conclusion—Putting it All Together
HD patients have unique vulnerability to healthcare-associated infections. This is because of a number
of human, environmental, and procedural factors related to the HD setting, in addition to a multitude
of patient comorbidities.
Establishing an infection prevention and control program which includes a bundle of strategies and
interventions that are consistently performed will reduce the risk for both employees and patients.
These include the following:
• 1. Environmental cleaning/disinfection
• 2. Equipment cleaning/disinfection
• 3. Hand hygiene
• 4. Immunizations and screening for patients and employees
• 5. Medication/injection safety
• 6. Patient/family/employee education
• 7. Pre-/postsurgical infection prevention
• 8. Standard/Transmission-Based Precautions
• 9. Vascular access—infection prevention during insertion and care
• 10. Water treatment/testing
• 11. Infection surveillance
• 12. Quality improvement program

Infection control for_hemodialysis_facilities

Infection control for_hemodialysis_facilities

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