This document discusses inhalant use disorder and nicotine abuse. It defines inhalant use disorder as the deliberate inhalation of volatile substances like glue, gasoline and cleaning fluids to induce psychoactive effects. Commonly abused inhalants include solvents, aerosols, gases and nitrites. Nicotine abuse is defined as the use of nicotine, found in tobacco, leading to addiction. Symptoms of inhalant and nicotine intoxication and withdrawal are described. The management of these disorders involves pharmacological and psychosocial interventions. Nurses play an important role in education, monitoring, administration of treatment and supporting recovery.