Python was created by Guido van Rossum in the late 1980s and named after Monty Python. It is a general purpose, high-level programming language that supports multiple paradigms like object-oriented, functional, and imperative programming. Django is a Python web framework that grew out of a newspaper project and follows the MVC pattern, separating concerns into models, views, templates. It provides tools for authentication, forms, administration, and more so that developers can focus on their specific applications.