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ION CHANNELS
Presented By-
Ashutosh Tambare
Ashwin kolhatkar
Jayti saparia
Kriti Katyayan
Raghuramreddy
Rajan Pandey
OUTLINE
• Whatareionchannels?
• Channelstructure
• TypesofGatinginIonChannels
• Thesodium-potassiumpump
• Workingofionchannels
• Importanceofionchannels
WHATAREION
CHANNELS???
Theyareporoustransmembral proteinswhichhelp
inregulatingthevoltagegradientacrosstheplasma
membrane byallowingionstodiffusethroughthe
poresdowntheirelectrochemical gradients.
WHY DO WE
NEED THEM???
IonsCannotDiffuseAcrosstheHydrophobic
BarrieroftheLipidBilayer.
Structure???
Types of Gating in Ion Channels
There are Four Types of Gating Controls -
1. Ligand Gating 2. Phosphorylation
Ion channels.ppt
TheSodium-PotassiumPump
Extracellular
fluidwithhigh
concentration
ofNa+
Cytoplasm
withhigh
concentration
ofK+
1
ThreeNa+ bind
tothe
cytoplasmicside
of theprotein.
2
Phosphateis
transferredfrom
ATPtotheprotein.
3
Phosphorylation
changesthe
shapeofthe
protein,moving
Na+ acrossthe
membrane.
4
K+ bindsto
theprotein,causing
phosphate
release.
5
Releaseof
phosphate
changesthe
shapeofthe
protein,
movingK+ to
thecytoplasm.
Na+
ATP ADP
P
Na+
P
K+
P
K+
Ion channels.ppt
+ + + +
- - - -
Vm = Q/C
∆Vm = ∆Q/C
THELIPIDBILAYERACTSLIKEACAPACITOR
∆Qmustchangebefore
∆Vm canchange
CHANGEINCHARGESEPARATIONACROSS
MEMBRANECAPACITANCEISREQUIREDTOCHANGEMEMBRANE
POTENTIAL
-
-
-
-
-
-
-
--
-
-
-
-
-
+
+
+
+
+
+
+
+
-
-
+
+
+
+
+
+
+
+
IMPORTANCEOFIONCHANNELS
• Mediatethegeneration,conductionandtransmissionofelectrical
signalsinthenervoussystem
• Controlthereleaseofneurotransmittersandhormones
• Transfersmallmoleculesbetweencells(gapjunctions)
THANK YOU

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Ion channels.ppt

Editor's Notes