Managing hypertension & hypotension
2 likes499 views
The document discusses the management of hypertension and hypotension. It explains that for hypertension, baroreceptors in the brainstem sense increased blood pressure and stimulate alpha-2 receptors, decreasing sympathetic discharge and lowering total peripheral resistance and cardiac output to reduce blood pressure. For hypotension, decreased blood pressure increases sympathetic activity, activating beta-2-1 adrenoreceptors in the heart to increase cardiac output and alpha-1 adrenoreceptors in smooth muscle to increase peripheral resistance. This triggers the renin-angiotensin-aldosterone system to retain sodium and water, increasing blood volume and blood pressure.
Managing hypertension & hypotension
- 1. PHARMACOLOGY SUBMITTED TO: Dr Huma Riaz SUBMITTED BY: Mehrwar Hijab
- 2. MANAGING HYPERTENSION BP Increase Baroreceptors sense pressure Stimulateα2 receptors in Brainstem Decrease Sympathetic discharge Decrease TPR, Decrease CO BP decrease
- 3. MANAGING HYPOTENSION _________________________________ ↓ BP ↑ Sympathetic activity Actvation of β21 adrenoreceptors of the heart ↑ cardiac output Activation of α1 adrenoreceptors of smooth muscle ↑ peripheral resistance ↓ Renal blood flow ↑ Renin ↑ Angiotensin II ↑ Aldosterone ↓ Glomerular filtration rate ↑ Sodium, water retention ↑ Blood volume ↑ BP