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MC LAFFERTY.pptx
- 1. PREPARED BY SUNNY MAURYA M.PHARM SECOND SEMESTER (PHARMACEUTICAL CHEMISTRY) ADVANCED SPECTRAL ANALYSIS SCHOOL OF PHARMACEUTICAL SCIENCES 1
- 2. Contents MC LAFFERTYREARRANGEMENT INTRODUCTION GAMMA HYDROGEN REARRANGEMENT MECHANISM APPLICATION REFERENCES 2
- 3. Mc lafferty rearrangement Fred Warren McLafferty was an American chemist known for his work in mass spectrometry. He is best known for the McLafferty rearrangement reaction that was observed with mass spectrometry. Mass spectroscopy is a technique used to determine the mass of a given molecule. The molecule is placed inside the spectrometer and ionized by high-energy electrons. After the molecules are ionized, they become radical cations that can then be sorted and weighed. 3
- 4. Mc lafferty rearrangement When hydrogen is available at the -position on carbonyl compounds, these compounds go through a specific rearrangement due to the cleavage of multiple bonds, including the bonds at and -positions. This reaction is known as the McLafferty rearrangement. The rearrangement involves a six-membered ring transition state in which the carbonyl group pulls off the -proton, splitting the molecule into two pieces. These pieces consist of an enol radical cation and a neutral alkene fragment. 4
- 5. -hydrogen should contain Aldehyde Ketone Ester Carboxylic acid amides 5
- 6. Rearrangement in carbonylcompound 6
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- 9. Rearrangement in ketone& carboxylic acid 9
- 10. Application Molecular weightdetermination Element analysis Structural elucidation using mass specroscopy 10
- 11. References https://www.slideshare.net/Justsci/mclafferty- rearrangementpptx https://www.slideshare.net/darshanNU/mclaffertey- rearrangement https://www.slideshare.net/MahendraMahi28/mc- lafferty-rearrangement 11
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