Melatonin_as_Root_Canal_Medicahhment.pptx

Melatonin_as_Root_Canal_Medicahhment.pptx

• 1.
  Melatonin as aRoot Canal Medicament • An Emerging Biomolecule in Endodontics • Presented by: Richa Ranjan • Department of Conservative Dentistry & Endodontics
• 2.
  Introduction to Melatonin •• Naturally occurring hormone (N-acetyl-5- methoxytryptamine) • • Secreted by pineal gland • • Known for regulating sleep-wake cycle • • Recent interest in dentistry: anti- inflammatory, antioxidant, regenerative properties
• 3.
  Why Consider Melatoninin Endodontics? • • Inflammation modulation • • Antioxidant potential • • Promotes tissue healing • • Biocompatible • • Comparable effects to MTA in pulp-capping models
• 4.
  Formulations Studied • Application| Form | Study Model • -------------------------------------- • Final Irrigant | 0.2% melatonin | Extracted human teeth • Intracanal medicament | Mixed with Ca(OH)₂ | In vitro • Systemic for AP | Injection | Rat model • Pulp capping | Topical gel/tablet | Rat molars
• 5.
  Study 1 –Irrigant Effect • • Title: Melatonin as an irrigation solution to enhance sealer adhesion • • Source: ResearchGate, 2019 • • 0.2% melatonin used after NaOCl • • Tested with AH-Plus sealer • • Result: Higher push-out bond strength in coronal & middle thirds
• 6.
  Study 2 –Animal Model • • Title: Melatonin for Apical Periodontitis in Rats • • Source: Wiley Online Library • • Induced AP in rats • • Systemic melatonin given • • Result: Reduced inflammatory lesion size and enhanced healing
• 7.
  Study 3 –Melatonin in Pulp Therapy • • Source: MDPI / PMC • • Pulp capping with melatonin • • Comparable to MTA in dentin bridge formation • • Enhanced pulp vitality • • Reduced cytokines: TNF α, IL 1β, MMP 2 ‑ ‑ ‑
• 8.
  Proposed Mechanism ofAction • Melatonin Acts via: • • ↓ Reactive oxygen species (ROS) • • ↓ Pro-inflammatory cytokines • • ↑ Growth factors (TGF-β1) • • ↑ Osteogenic activity • • Promotes dentin-pulp complex healing
• 9.
  Potential Research Directions •• As intracanal medicament • • Combined with Ca(OH)₂ or CHX • • As root canal sealer additive • • Long-term in vivo outcomes • • Effect against E. faecalis and C. albicans
• 10.
  Conclusion • • Melatoninshows promising results in endodontic applications • • Safe, biocompatible, and anti-inflammatory • • Needs further clinical validation • • Can be a future biomolecule for regenerative endodontics
• 11.
  References • 1. ResearchGate– Melatonin as irrigation solution – 2019 • 2. Wiley – Melatonin in apical periodontitis – 2022 • 3. MDPI/PMC – Melatonin in pulp therapy – 2020 • 4. Çelik B et al. Int Endod J – 2021
• 12.
  Thank You • AnyQuestions? • Richa Ranjan | MDS Endodontics • Department of Conservative Dentistry & Endodontics