This document tracks the evolution of Pakistan–U.S. relations from 1947 to 2025, detailing Cold War-era alignments, CIA-ISI cooperation, post-9/11 duplicity, and the current transactional reset under Donald Trump’s second term. From Operation Cyclone to Osama bin Laden, drone warfare to Afghanistan withdrawals, and CPEC to India’s rise this timeline-driven brief reveals how Islamabad and Washington have used each other tactically without building genuine trust. Ideal for researchers, journalists, diplomats, and anyone tracking South Asian geopolitics and intelligence dynamics.