Pathology of Urinary Tract Infectionws

Pathology of Urinary Tract Infectionws

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  Pain nourishes courage.You can't be brave if you've only had wonderful things happen to you. – Mary Tyler Moore
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  CLINICAL PATHOLOGY The foundationof clinical medicine. Shashidhar Venkatesh Murthy A/Prof & Head of Pathology College of Medicine & Dentistry BPH2: Urinary Tract Dis: UTI CPC : Term4 Week3 - BPH 2/6 System : Urinary Tract. Topic : 1: Overview 2: UTI 3: BPH 4: Tumours 5: Obstructions Lithiasis 6: Others 7: GLS
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  3 UTI: Overview  Urethritis,Cystitis, Prostatitis, Pyelonephritis  90% by Escherichia coli *, Recurrence (40%),  Uropathogenic strains (UPEC). P fimbriae or pili – bind to urothelium.  Colonize colon spread to urinary tract.  Staph. Saprophyticus, Proteus, Klebs., Entero., Ureaplasma.. - Rare Clinical:  Females*, Anatomy*, sexual, UT abnormality / Obstructions.  Dysuria, Low grade fever, frequency, urgency,  Flank pain, high fever, – pyelonephritis.  Complications: E coli septicemia* endotoxins  DIC*, Prostatitis, Prostatic abscess.
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  A friend issomeone with whom you dare to be yourself. – Frank Crane
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  5 UTI: Diagnosis: Ecoli  Blood: Leukocytosis – neutrophilia  Midstream clean catch Urine specimen*  Dipstick: Leukocyte esterase & nitritie +ve.  Urine: pyuria, neutrophils, bacteria, Microscopy gram stain:  Gram negative Bacilli, Lactose fermenting.  Also Entero.. & Klebsiella ferment lactose.  Further tests to confirm: E coli  urease –ve (unlike Klebsiella & Proteus +ve)  MacConkey agar* selective, indicator media.  24h, 37°C, Aerobic, Pink colony (lactose ferment  acid  pH indicator),  Beta-hemolytic on blood agar.
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  A friend issomeone with whom you dare to be yourself. – Frank Crane