PLATELET ACTIVATING FACTOR

PLATELET ACTIVATING FACTOR

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  ASSIGNMENT PRESENTED TO Dr.TARIQUE MAHMOOD ASSOCIATE PROFESSOR & HEAD Mrs. ARSHIYA SHAMIM ASST. PROFESSOR PRESENTED BY MULAYAM SINGH DOCTOR OF PHARMACY (2nd YEAR) SESSION : 2018-19 PHARMACOLOGY - 1 PRY - 206 INTEGRAL UNIVERSITY , LUCKNOW FACULTY OF PHARMACY M.sin gh
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  M.sin gh Platelet activating factor: Mechanismof action & Clinical uses
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  Platelet-activating factor (PAF)is a lipid mediator that is well-known for its ability to cause platelet aggregation, inflammation, and allergic response at very low concentrations (approaching picomolar). M.sin gh
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  Platelets are tinyblood cells that help your body form clots to stop bleeding. If one of your blood vessels gets damaged, it sends out signals that are picked up by platelets. The platelets then rush to the site of damage and form a plug, or clot, to repair the damage. M.sin gh
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  M.sin gh
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  M.sin gh In pharmacology, the termmechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.
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  relating to orbased on work done with real patients : of or relating to the medical treatment that is given to patients in hospitals, clinics, etc. : requiring treatment as a medical problem. : of or relating to a place where medical treatment is given : of or relating M.sin gh
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  What is plateletactivating factor..??  Platelet-activating factor is a potent biological mediator that exerts its effects in a variety of cells and tissues.  Platelet-activating factor, also known as PAF, PAF- acether or AGEPC (acetyl-glyceryl-ether- phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, including 1) platelet aggregation 2) degranulation 3) inflammation, and 4) anaphylaxis. continue…. M.sin gh
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  M.sin gh continue….It is alsoinvolved in changes to vascular permeability, the oxidative burst, chemotaxis of leukocytes, as well as augmentation of arachidonic acid metabolism in phagocytes.  PAF is produced by a variety of cells, but especially those involved in host defense, such as platelets, endothelial cells, neutrophils,
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  Synthesis of PAF PAF is synthesized from precursor phospholipids present in cell membrane by the following reactions: Membrane Acyl-glycero phosphocholine Phospholipase A2 Fatty acid Lyso PAF PAF-acetl transferase PAF Acetyl CoA CoA  The second step is rate limiting. Antigen-antibody reaction and a variety of mediators stimulate PAF synthesis in a Ca2+ dependent manner on demand: there are no preformed stores of PAF.  In contrast to eicosanoids, the types of cells which synthesize PAF is quite limited—mainly WBC, platelets, vascular M.sin gh
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  PAF is degradedin the following manner : PAF Lyso PAF Acyl glycerophosphocholin (gets incorporated in the membrane) PAF acetyl- hydrolase Acyl- transferase Acetate Fatty acid Degradation of PAF M.sin gh PAF :- platelet activating factor Lyso PAF :- Lysophosphatidylcholine
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  M.sin gh
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  M.sin gh audience
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  M.sin gh