Posterior Segment Company Showcase - Notal vision

Posterior Segment Company Showcase - Notal vision

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  Quinton Oswald Chief ExecutiveOfficer O I S @ AAO O c t o b e r 1 3 2 0 1 6
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  [ 2 ] ANEW PARADIGM FOR THE Detection of Ocular Diseases FI RST APPLI C ATI ON Age-Related Macular Degeneration (AMD) The #1 Cause of Vision Loss in People 60+* … in diseases where early detection can dramatically affect outome * In developed countries P H Y S I C I A N - D R I V E N Diagnosis and Treatment PAT I E N T- A C T I VAT E D Detection T E C H N O L O G Y - E N A B L E D
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  [ 3 ] AMDInnovation Focused on Physician-Driven Diagnosis and Treatment 1MarketsandMarkets Report 2 GlobalData estimate of 2023 AMD Global Treatment Market ACCURATE DIAGNOSIS EFFECTIVE TREATMENT Optical Coherence Tomography (OCT) Anti-VEGFs and Future Novel Therapies Driving Significant Markets HOWEVER: $1B1 ~$10B2 Detection Is Not Timely Treatment Demonstrates Efficacy but Functional Vision May Never Be Restored
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  [ 4 ] BroadMacro Trends Support Focus on Patient Empowerment 2 Technology-Enabled Remote Detection and Diagnosis 1 Earlier Disease Detection Drives Better Outcomes 3 Reimbursement Becomes Outcomes-Driven $ $
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  [ 5 ] Visual Acuity Severe Vision Loss DryAMD Wet AMD Downward Cascade in Vision Loss May Go Unnoticed by Patients The Challenge: Timely Detection of Wet AMD Slow Progression Rapid Progression Therapeutics (e.g. Anti VEGFs) Treat Wet Form Only Within Weeks: Narrow Window to Detect Transition from Wet  Dry Finding Patients at the Turning Point of Disease … … So Early Treatment Can Preserve Functional Vision … 36 Million Globally with AMD THE DETECTION ‘LOTTERY’ THE CHALLENGE:
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  [ 6 ] Today:Vast Majority of Wet AMD Patients Are Diagnosed Too Late Driving Threshold i.e., ‘Functional Vision’ Normal Legal Blindness 20/200 20/40 20/20 TODAY’S REALITY Lost with Late Dx Gained with Tx -18 Letters +8 Letters ~70% * Below 20/40 20/40+ No Longer Have Functional Vision at Diagnosis BASELINE May Not Regain Functional Vision with Treatment … and * Analysis of Multiple AMD Studies
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  [ 7 ] CurrentDisease Detection Options Are Too Infrequent or Insensitive Low High CLINICAL ROBUSTNESS HighLow CONVENIENCE / FREQUENCY Household Items Amsler Grid Smartphone Apps At Home Patient-Activated Detection The Holy Grail In-Office OCT Physician-Driven Diagnosis
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  [ 8 ] CLINICAL ROBUSTNESS •94% Maintained Functional Vision (20/40+) in NIH Study • Objective measure • Sensitive Our Pioneering Innovation: Patient-Activated, Clinically Robust Early Disease Detection CONVENIENCE • 3 minute test per eye • Unique design tailored to older patient population – Device and Technology ecosystem • “Plug and play” • Results sent directly to physician PROVEN Preferential Hyperacuity Perimetry (PHP) Detects Onset of Neovascular Leakage within DAYS vs. Week / Months Before Patients Would Notice Change 3,000+ Patients 2 Million Tests 4-5x/Week (for avg. 3.3 yrs)  FDA Cleared  CE Marked  Medicare Coverage
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  [ 9 ] Alert– in event of statistically significant change 5Reminder calls 3 CLOUD HOSTING Notal Vision Data Monitoring Center A Complete, Personalized Monitoring System Early Detection in Action OUR ENGINE ROOM IN THE CLOUD • High touch • Technology-enabled • Scalable • Compliant and secure • Fully integrated billing/reimbursement 1 Patient takes test daily PHYSICIAN Physician office calls patient for office visit and treatment 6 Data automatically sent via embedded cellular modem 2 Ongoing monitoring • Monthly reports pushed • Online access 4 PATIENT
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  [ 10 ] COMPLEMENTARY FinallyCompleting the Missing Link for AMD Treatment and Diagnosis PHYSICIAN-DRIVEN Formal Diagnosis and Treatment with Effective Current and Future Therapies 2006 PATIENT-ACTIVATED Convenient, Objective, Accurate Early Detection 2016 THE NEW REALITY Taking AMD Treatment to the Next Level ... Shift from Regaining Vision ... ...to Not Losing It in the First Place Enabling Timely Treatment
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  THANK YOU QUINTON OSWALD,CEO [email protected] (650) 255-4557
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