The document summarizes a career panel discussion on preparing for informatics careers and trends in health information technology (HIT) in the age of meaningful use. The panel included experts from academia and industry with clinical, technical, and health IT vendor backgrounds. They discussed their career experiences and trajectories, key factors that influenced their informatics careers, upcoming trends in HIT like interprofessional education and personalized clinical decision support, and implications for students. The panel provided advice to students on gaining experience through volunteering, networking, obtaining credentials, and participating in practical projects to prepare for emerging opportunities in HIT.