This document provides guidance for project management offices (PMOs) to be successful in large projects. It discusses that a PMO's responsibilities can range from providing project support to direct management. Key skills for a PMO include understanding projects at a high level, identifying issues and risks, and mapping stakeholders. The document also outlines the components of a PMO's toolkit such as templates, a risk register, and status reports. It emphasizes the importance of removing ambiguity by not accepting "to be determined" tasks and by clearly communicating the true status of projects and issues. Finally, it presents secrets to PMO success including focusing on scope, time, costs, risks, and communication while prioritizing, supporting the project manager, and interpreting