prinz metal angina.pptx

prinz metal angina.pptx

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  Department of PharmaceuticalChemistry Presenting by: Mr. PURUSHOTHAM K N Assistant Professor Department of Ph. Chemistry SACCP B. G. Nagar 2021-2022 Prinz metal Angina 1
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  Contents • Introduction • Typesof angina • Prinz metal angina • Causes • Symptoms 2
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  Prinz metal Angina •Prinz metal angina also known as variant angina ,vasospastic angina is a syndrome typically consist of angina. • Variant angina differ from stable angina in that it commonly occurs in individuals who are at rest are even a sleep, whereas stable angina is generally triggered by exertion or intense exercise • Variant angina is caused by vasospasm a narrowing of the coronary arteries due to contraction of the heart’s smooth muscle tissue in the vessel wall. 3
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  • Stable anginais caused by the permanent occlusion of these vessels by atherosclerosis which is the build-up of fatty plaque and hardening of the arteries 4
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  Causes of Prinzmetal angina • Prinz metal angina is caused by spasms of the coronary arteries, or the arteries that bring blood and oxygen to your heart. The lack of oxygen causes the pain that you feel. If prolonged, this can cause damage to the heart muscle. • Medications that are intended to constrict (or narrow) blood vessels, such as migraine treatments like decongestants that contain ephedrine. • Use of drugs like marijuana and cocaine. • Smoking tobacco. • Stress. • Exposure to cold. • Exercise causes coronary artery spasms 6
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  The symptoms ofvariant angina include: • Intermittent chest pain that: Occurs while resting, or during the overnight or early morning hours. ... • Nausea. • Sweating. • Palpitations—rapid, irregular, or skipped heartbeats. • Lightheadedness. • Trouble breathing. 7
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  Role of thromboxanein Prinz metal angina • One of the major function of the thromboxane is to perform Vaso constriction. • Thromboxane and prostacyclin as opposite role. • Vaso constriction caused by thromboxane play a important role in Prinz metal angina and blocked coronary artery. • Thromboxane A2 is potent Vaso constrictor and thromboxane A3 is less potent Vaso constrictor. • Prostacyclin act as a Vaso dilator while thromboxane A2 as a Vaso constrictor effect. 8
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  Thromboxane A2 ThromboxaneA3 Vaso-constrictor Less potent Vaso-constrictor 9
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  Prostacyclin Act as Vaso-dilators 10
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  TREATMENTS • Prinz metalangina is treated with medications and lifestyle changes. The types of drugs used to treat Prinz metal angina include: • Nitrates: These can be given in sublingual tablets, oral tablets or capsules or patches. • Calcium channel blockers: These include diltiazem, amlodipine, nifedipine and verapamil. • Fluvastatin: A statin medication that may have a positive effect on the lining of the blood vessels. 11
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  • Medications likebeta blockers and aspirin, often used in other heart conditions, aren’t used for Prinz metal angina. • Lifestyle modifications include quitting smoking and avoiding substances that cause spasms, such as: • Drugs, including marijuana or cocaine. • Medications that constrict blood vessels, like many migraine treatments, nasal decongestants, weight loss medications and energy drinks. 12
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  REFERENCE • https://my.clevelandclinic.org/health/diseases/21867-prinzmetal- angina • Wikipedia •https://www.ncbi.nlm.nih.gov/books/NBK430776 13
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  THANK YOU 14