Rational use of drugs involves prescribing the right drug, in the right dose, by the right route and at the right time for the right patient. It aims to provide patients with medications appropriate to their clinical needs, in doses that meet their own individual requirements for an adequate period of time, and at the lowest cost to them and their community. Factors that have led to increased focus on rational drug use include the explosion in the number of available drugs, efforts to prevent antimicrobial resistance, growing public awareness, and rising healthcare costs. Irrational drug use can occur at the levels of diagnosis, prescribing, dispensing, patient adherence, and includes practices like polypharmacy, inappropriate use of antibiotics, and failure to follow clinical guidelines.