Rational use of medicine aims to ensure patients receive appropriate medications based on their needs. Irrational use can occur when there is polypharmacy, unnecessary or incorrect medications, underuse of effective medicines, or unsafe drug use. This presentation identifies factors contributing to irrational use at the international, national, health systems, prescriber, dispensing, and patient levels. These include issues like drug promotion, regulations, infrastructure, education and adherence. Strategies to improve rational use involve educational programs for prescribers and patients, management techniques, economic approaches, and regulatory policies like essential drug lists and multi-disciplinary oversight bodies.