Sliding Filament Theory Lloyd Dean How Muscles Contract
Structure of Skeletal Muscle: Microstructure Sarcolemma Muscle cell membrane Myofibrils Threadlike strands within muscle fibers Actin (thin filament) Troponin Tropomyosin Myosin (thick filament) Further divisions of Myofibrils Z-line A-band I-band Sarcoplasm Sarcoplasmic reticulum Storage sites for calcium Surrounds myofibrils Transverse tubules
 
 
 
Muscular Contraction The sliding filament model Muscle shortening occurs due to the movement of the actin filament over the myosin filament Reduction in the distance between Z-lines of the Sarcomere Lets see a preview before the play………..
Sliding Filament Theory: A Love Story Winner of 2 Golden Globes and 3 Oscar’s. Directed by Lloyd Dean and his award winning students The background Actin and Myosin are in deeply in love and wish to live a happy life together and stay in full muscle contraction.  The nasty Tropomyosin has other idea’s……. Let’s see the cast……..
Cast Actin  –  The thin protein that needs some HELP to join with Myosin  Myosin   -  The thick protein  Acetylcholine  –  A helping hormone Troponin  –  Will assist in removing the horrid tropomyosin from actin Tropomyosin  –  Doesn’t want actin and myosin to become attached ATP  –  Energetic friend Calcium  –  Will it win it’s battle against tropomyosin ? Nervous Impulse  -  Messenger Now to the chapters of this story.........
Chapters A Milky Message Two Forces Join  A   T iresome  P ull Powering Through A Milky Removal
A Milky Message Nerve Impulse sent to neuromuscular junction (Place where the brain and muscle communicate) Hormone (Acetylcholine) diffuses  This causes calcium ions to be released in the sarcoplasmic reticulum (Surrounds myofibrils)
 
Two Forces Join Calcium ions join with troponin  Causes tropomyosin to be removed from actin Actin and myosin join together
A   T iresome  P ull Actin and myosin are now joined Myosin pulls actin inwards slightly ATP enables quick detachment of actin and myosin in preparation for power stroke
Powering Through ATP is broken down  This enables Myosin to powerfully pull actin inwards Sarcomere and distance between Z discs shortens This process continues at a high rate and as long as there are calcium ions present
A Milky Removal Once impulse stops.... Calcium Ions are sent back to sarcoplasmic reticulum Tropomyosin rejoins actin Sarcomere and Z disc distance increase Muscle is relaxed
All or None Law Fiber contracts completely or not at all
 
 
 

Sliding filament theory muscle contraction

  • 1.
    Sliding Filament TheoryLloyd Dean How Muscles Contract
  • 2.
    Structure of SkeletalMuscle: Microstructure Sarcolemma Muscle cell membrane Myofibrils Threadlike strands within muscle fibers Actin (thin filament) Troponin Tropomyosin Myosin (thick filament) Further divisions of Myofibrils Z-line A-band I-band Sarcoplasm Sarcoplasmic reticulum Storage sites for calcium Surrounds myofibrils Transverse tubules
  • 3.
  • 4.
  • 5.
  • 6.
    Muscular Contraction Thesliding filament model Muscle shortening occurs due to the movement of the actin filament over the myosin filament Reduction in the distance between Z-lines of the Sarcomere Lets see a preview before the play………..
  • 7.
    Sliding Filament Theory:A Love Story Winner of 2 Golden Globes and 3 Oscar’s. Directed by Lloyd Dean and his award winning students The background Actin and Myosin are in deeply in love and wish to live a happy life together and stay in full muscle contraction. The nasty Tropomyosin has other idea’s……. Let’s see the cast……..
  • 8.
    Cast Actin – The thin protein that needs some HELP to join with Myosin Myosin - The thick protein Acetylcholine – A helping hormone Troponin – Will assist in removing the horrid tropomyosin from actin Tropomyosin – Doesn’t want actin and myosin to become attached ATP – Energetic friend Calcium – Will it win it’s battle against tropomyosin ? Nervous Impulse - Messenger Now to the chapters of this story.........
  • 9.
    Chapters A MilkyMessage Two Forces Join A T iresome P ull Powering Through A Milky Removal
  • 10.
    A Milky MessageNerve Impulse sent to neuromuscular junction (Place where the brain and muscle communicate) Hormone (Acetylcholine) diffuses This causes calcium ions to be released in the sarcoplasmic reticulum (Surrounds myofibrils)
  • 11.
  • 12.
    Two Forces JoinCalcium ions join with troponin Causes tropomyosin to be removed from actin Actin and myosin join together
  • 13.
    A T iresome P ull Actin and myosin are now joined Myosin pulls actin inwards slightly ATP enables quick detachment of actin and myosin in preparation for power stroke
  • 14.
    Powering Through ATPis broken down This enables Myosin to powerfully pull actin inwards Sarcomere and distance between Z discs shortens This process continues at a high rate and as long as there are calcium ions present
  • 15.
    A Milky RemovalOnce impulse stops.... Calcium Ions are sent back to sarcoplasmic reticulum Tropomyosin rejoins actin Sarcomere and Z disc distance increase Muscle is relaxed
  • 16.
    All or NoneLaw Fiber contracts completely or not at all
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  • 19.