Spain and Portugal were the first European nations to colonize the Americas in the 15th and 16th centuries. Christopher Columbus' voyages for Spain in 1492 led to Spanish conquest and colonization of the Caribbean islands. Explorers like Hernan Cortes then conquered powerful civilizations like the Aztecs and Incas for Spain, establishing the first Spanish colonies in Mexico and South America. Other European powers like England, France, and the Netherlands soon established their own colonies in North America through the 17th century, competing for territory and resources. This led to conflicts between the colonial powers and also disrupted indigenous populations through warfare and disease.