The Alienist by Caleb Carr takes place in late 19th century New York City. Police Commissioner Theodore Roosevelt forms a team, including Dr. Laszlo Kreizler and Detective Sergeants Marcus and Lucius Isaacson, to catch a serial killer. Through autopsy and analysis of the killer's neuroanatomy, Kreizler proves his theory that the killer suffers no physical brain deterioration. After nearly becoming victims themselves, the team captures the serial killer.