Uploaded byWaleed K. O. Jaber
Thrombosis
The document discusses coagulation, the process by which blood clots. More than 30 cells and substances affect clotting, which is initiated by platelets and involves a complex series of reactions converting fibrinogen into fibrin to form a clot. Thrombosis occurs when a blood clot forms inside a blood vessel or heart, partially or completely blocking blood flow. Causes of clotting include the blood composition, vessel wall injuries, and blood flow issues. Clots are classified as venous, such as deep vein thrombosis, or arterial, like those causing strokes and myocardial infarctions when coronary arteries suddenly clog.
In this document
Powered by AI
This slide introduces Waleed K.O. Jaber as the presenter.
Thrombosis is defined as blood clot formation inside blood vessels or heart, obstructing blood flow.
Coagulation involves multiple blood components and processes leading to clot formation through thrombin and fibrin.
Key causes include hypercoagulability, vascular wall injury, and abnormal blood flow.
Classification of venous thrombosis begins, focusing on deep vein thrombosis.
Discusses portal vein thrombosis affecting blood supply to the liver and portal hypertension.
Details renal vein thrombosis, highlighting obstruction of the renal vein.
Focuses on jugular vein thrombosis.
Introduction to arterial thrombosis including strokes.
Continues arterial thrombosis discussion focusing on myocardial infarction.
Details the process of myocardial infarction due to plaque rupture causing thrombus formation.
Includes a drawing showing anterior left ventricle wall infarction.
More Related Content
Thrombosis
- 1.
- 2. Def.: Thrombosis is the formationof a blood clot inside a blood vessel or the heart, which can partially or completely obstruct the flow of blood. The blood clot itself is referred to as a THROMBUS.
- 3. Coagulation: In medicine,the clotting of blood. The process by which the blood clots to form solid masses, or clots. # More than 30 types of cells and substances in blood affect clotting. The process is initiated by blood Platelets. Platelets produce a substance that combines with calcium ions in the blood to form thromboplastin, which in turn converts the Protein Prethrompin into Thrombin in a complex series of reactions. Thrombin, a proteolytic enzyme, converts Fibrinogen, a protein substance, into fibrin, an insoluble protein that forms an intricate network of minute threadlike structures called fibrils and causes the blood plasma to gel. The blood cells and plasma are enmeshed in the network of fibrils to form the clot.
- 4. Causes: The compositionof the blood (hypercoagulability or thrombophilia) Quality of the vessel wall (endothelial cell injury) Nature of the blood flow (stasis, turbulence)
- 5. Classification: Venous thrombosis: Deep vein thrombosis
- 6. • Portal veinthrombosis (affecting the hepatic portal vein ) portal hypertension & blood supply to the liver.
- 7. Renal vein thrombosis (obstruction of the renal vein )
- 8. Jugular veinthrombosis
- 9. Arterial thrombosis: Stroke
- 10.
- 12. A myocardial infarctionoccurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, causing catastrophic thrombus formation, totally occluding the artery and preventing blood flow downstream.
- 13. Drawing of theheart showing anterior left ventricle wall infarction