Venture Capital as a Catalyst to
Commercialization

Sampsa Samila and Olav Sorenson




                                   1
2
$241 billion
invested in
research by
OECD
governments
in 2007


               2
Some
regions
have
benefited,
but not all
equally...

              3
Some
regions
have
benefited,
but not all
equally...

              3
4
Atlanta?




           4
12         10
Log of Patents 1993-2002
4       6   2   8




                            5       10               15             20           25
                                   Log of Federal R&D Support 1993-2002

                                Log of Patents 1993-2002         Fitted values




                                                                                      5
12
  Log of Count of Startups 1993-2002
7      8      9       10     11




                                        5        10               15             20           25
                                                Log of Federal R&D Support 1993-2002

                                            Log of Startups 1993-2002         Fitted values




                                                                                                   6
7
Claim:
Venture capital catalyzes
commercialization




                            7
8
Start-up vs. existing firms




                             8
9
Redirecting research




                       9
10
Complementary assets/skills




                              10
11
Solution to agency problems




                              11
INVESTECO PRIVATE
                       EQUITY FUND III
                             Limited partners

                       $


                           ve ry
                        ity l!
                     tiv a
                    c c Portfolio companies
                   A lo
General partners       $




                                                12
12
Log of Patents 1993-2002
4       6  2    8     10




                           5    10               15             20         25
                               Log of Federal R&D Support 1993-2002

                                 MSAs with VC            MSAs without VC
                                 Fitted values           Fitted values




                                                                                13
12
 Log of Count of Startups 1993-2002
7      8     9      10     11




                                      5    10               15             20         25
                                          Log of Federal R&D Support 1993-2002

                                            MSAs with VC            MSAs without VC
                                            Fitted values           Fitted values




                                                                                           14
Empirical Setting
 Metropolitan
                 Metropolitan Areas of the United States and Puerto Rico: 1999
                  ALASKA                                                                                                                                                                                                                                                                                                                                                             INSET

                                                                                                                                                                                                                                                                                                                                                                                         0           50             100 Kilometers
                   0        300      600         900 Kilometers                                                                                                                                                                                                                                                                                                                                                                                      Manchester




 United States
                                                                                                                                                                                                                                                                                                                                                                                         0                     50                 100 Miles
                   0               300             600 Miles                                                                                                                                                                                                                                                                                                                                        1:6,000,000                                                                 Portsmouth-Rochester
                           1:45,000,000                                                                                                                                                                                                                                                                                                                                                                                          Fitchburg-     Nashua
                                                                                                                                                                                                                                                                                                                                                                                                                                 Leominster Lowell
                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Lawrence
                                                                                                                                                                                                                                                                                                                                                                                                                                      Worcester
                                                                                                                                                                                                                                                                                                                                                                                                                                      SPRINGFIELD                                BOSTON-WORCESTER-
                                                                                                       ANCHORAGE                                                                                                                                                                                                                                                                                                                                                                     LAWRENCE
                                                                                                                                                                                                                                                                                                                                                                                                              PITTSFIELD
                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Boston
                                                                                                                                                                                                                                                                                                                                                                                                                           HARTFORD                                             Brockton



                                                                                                                                                                                                                                                                                                                                                                                                     Waterbury
                                                                                                                                                                                                                                                                                                                                                                                                       Danbury                                                                    BARNSTABLE-YARMOUTH
                                                                                                                                                                                                                                                                                                                                                                                                    Stamford-
                                                                                                  BELLI                                                                                                                                                                                                                                                                                             Norwalk                                                       New Bedford
                                                                                       SEATTL
                                                                                             E-TACOM NGHAM                                                                                                                                                                                                                                                                                                                              NEW LONDON-




 1993 - 2002
                                                                  Bremer                             A-BREME                                                                                                                                                                                                                                                                                                                                                   PROVIDENCE-
                                                                        ton                                                                                                                                                                                                                                                                                                                                                   New Haven- NORWICH           FALL RIVER-WARWICK
                                                                                               Seatt
                                                                                                            RTON                                                                                                                                                                                                                                                                                              Bridgeport        Meriden
                                                                                                      le-
                                                                                                Bellevu            SPOKANE                                                                                                                                                                                                                                                                                NEW YORK-NORTHERN NEW JERSEY-
                                                                                                Everette-                                                                                                                                                                                                                                                                                                       LONG ISLAND (PART)
                                                                   Olym
                                                                       pia                  YAKIMA
                                                                                                   RICHLAND                                  MISSOULA                                                                                                                                                                                                                                                                                                                                                                           BANGOR
                                                                                                            -KENN
                                                                         Tacom                            PASCO EWICK-                                                 GREAT FALLS
                                                                                   a
                                                                                                                                                                                                                                                                  GRAND FORKS                                                                                                                                                                                                                                GTON
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       BURLIN
                                                                                                                                                                                                                                                    BISMARCK
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   BURN
                                                                                  Portlan                                                                                                                                                                                                                                                                                                                                                                                                                                                     ON-AU
                                                                                         d-Vanc                                                                                                                                                                                                                                                                                                                                                                                           ME                                            LEWIST
                                                                                  PORT         ouver                                                                                                                                                                                                                                                                                                                                                                              UTICA-RO BANY- Y-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         AL CTAD                                      PORTLA
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            ND
                                                                                         LAND-S
                                                                   CORVALL       Salem         ALEM                                                                                                                                                                                                           DULUTH-SUPERIOR                                                                                                                                                         SCHENEOY           GLENS
                                                                          IS                                                                                                                                                                                           FARGO-MOORHEAD                                                                                                                                                                                                       TR            FALLS
                                                                                                                                                                                                                                                                                                                                                                                                 SAGINAW- -
                                                                               EUGENE                                                                                                        BILLINGS                                                                                                                                                                                             BAY CITYD                                                                                                                                  SET
                                                                                     -SPRIN
                                                                                           GFIELD                                                                                                                                                                                             ST. CLOUD                               EAU CLAIRE    WAUSAU      GREEN
                                                                                                                                                                                                                                                                                                                                                                   BAY
                                                                                                                                                                                                                                                                                                                                                                                                  MIDLAN
                                                                                                                                                                                                                                                                                                                                                                                                                                                               SYRACU
                                                                                                                                                                                                                                                                                                                                                                                                                                                                     SE                                                                SEE IN
                                                                                                                                                                                                                                                                                                                                                                                                   DS-                                                                 TER
                                                                                                                                                                                                                                                                                                                                                                                        GRAND RAPI                                                              ROCHES
                                                                                                                                                                                                                                                                                                   MINNEAPOLIS-                                                                           MUSKEGON-                                   R-FLINT
                                                                                                                                                                                                                                                                                                                                                                                                                              NN ARBO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           k
                                                                                                                                                                                                                                                                                                     ST. PAUL                                                                               HOLLAND                                                                                   Newar           burgh
                                                                                                                                                                                                                                                                                                                                                        KOSH-
                                                                                                                                                                                                                                                                                                                                            APPLETON-OSH AH                                LANSING- G
                                                                                                                                                                                                                                                                                                                                                                                                                     DETROIT-ADetroit     BUFFALO
                                                                                                                                                                                                                                                                                                                                                                                                                                                 -
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           AMTON
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             New ses
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ic
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  -Passa
                                                                                                                                                                                                                                                                                                                                                      NEEN                                                         Flint                   or            FALLS                      BINGH                 Dutchnty                                        BergenSuffolk                   ISLAND
                                                                     MEDFOR                                                                                                                                                                                                                                                                                                              EAST LANSIN                             Ann Arb NIAGARA                                                            Cou                                                u-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Nassa rk                    -LONG
                                                                                                                                BOISE CITY                                                                                                                                                                       ROCHESTER                        SHEBOYGAN                                                                                                                    ELMIRA
                                                                           D-ASHLAN
                                                                                                                                                                                                                                                                                                                                                                INE                         JACKSON
                                                                                                                                                                                                                                                                                                                                                                                                                                             D- AKRO
                                                                                                                                                                                                                                                                                                                                                                                                                                                        N                                            ES-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               --WILK N                                               New ty
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Yo              JERSEY
                                                                                   D                                                                                                                                                       RAPID CITY
                                                                                                                                                                                                                                                                                                                           LA CROSSE         MILWAUKEE-RAC sha                   SOUTH                                           CLEVELAN WARREN                           OWN         RANTON ETO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  JAMEST T SCBARRE--HAZL                                                                  Ci
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Jersey-NORTHER rdon
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     N NEW
                                                                                                                                                  POCATELLO                                                                                                             SIOUX FALLS                                                         Milw   aukee-Wauke                    BEND                                        YOUNGSTO
                                                                                                                                                                                                                                                                                                                                                                                                                                         WN-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                       SPOR                                                                                      unte
                                                                                                                                                                                                                CASPER                                                                                                                          MADISON                      Racine                                           eveland-
                                                                                                                                                                                                                                                                                                                                                                                                                           Cl n-                              WILLIAM                                                                       NEex   YORK
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                W-Somerset-HSTON
                                                                                                                                                                                                                                                                                                                                                         -
                                                                                                                                                                                                                                                                                                                                              JANESVILLEIT                   Kenosha                                        Lorai                     ERIE             STATEGE                                                               es        LEHEM-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               EA
                                                                                                                                                                                                                                                                                                                                   DUBUQUE                                                                                                                                LLE                                                        Middl OWN-BETH
                                                                                                RENO                                                                                                                                                                                                                WATERLOO-
                                                                                                                                                                                                                                                                                                                                                    BELO                       BENTON                                        ElyriaAkron                   SHARON COGH
                                                                                                                                                                                                                                                                                                                                                     ROCKFORD                   HARBOR         KALAMAZOO-                                                      PITTSBUR N              LANCAST
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                ER                                    ALLENT n
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            to
                                                                                                                                                                                                                                                                                                                   CEDAR FALLS                                                                      BATTLE                                                                                                                            TrenING -Ocean
                                                                        REDDING                                                                                                                                                                                                                                                                                               Chicago                CREEK                                                      JOHNSTOW                                                               READ outh
                                                                                                                                                                                                                                                                              SIOUX CITY                                                                                                                                  CANTON-                                                                                                     Monm lphia                             C CITY
                                                   CHICO-PA
                                                           RADISE Sacra
                                                                                                                                                                                                                                                                                                                         CEDAR RAPIDS
                                                                                                                                                                                                                                                                                                                          DES                           CHICAGO-                              ART-
                                                                                                                                                                                                                                                                                                                                                                                                             TOLEDO MASSILLON
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Philade ape May INGTON-A
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      TLANTI
                                                                        mento                                                                                                                                                                                                                                                                               GARY-                        ELKH                 LIMA                                                            ALTOONA own                                                 tic-C          M
                                                Vallejo-           YUBA
                                                                                                                                                                                                        CHEYENNE
                                                                                                                                                                                                                                                                                                                          MOINES
                                                                                                                                                                                                                                                                                                                                                            KENOSHA                Gary GOSHEN                                  LD             LLE-                           Hagerst                                               Atlan PHIA-WIL ridgeton
                                               Fairfiel            CITY                                                                                                                                                                                                             OMAHA                                        IOWA CITY                                             FORT WAYNE                      MANSFIE        STEUBENVI                                                                                            EL illville-B
                                                Napa
                                                       d-                                                                                               SALT LAKE CITY-                                                                                                                                                          DAVEN  PORT-                        Kankakee LAFAYETTE                 OMO        COLUM BUS             WEIRTON                                                                                  PHILAD d-M-Newark
                                                                                                                                                                       OGDEN                                                                                                                                                        MOLINE-         PEORIA-                                         KOK                                                           RG-                                                             Vinelangton
                                                        Yolo                                                                                                                     FORT COLLINS-LOVELAND                                                                                                                                               PEKIN                                                                                  WHEELINGPARKERSBU                                                                    Wilm
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        in                  ISLE
                                 Santa                                                 SACR                                                                                                                                                                                                                                      ROCK ISLAND                                                                                                             MARIETTA MBERLAND -                                                                        ON-CARL
                                                                                                                                                                                                                               Greeley                                                                                                                                                                 MUNCIE                                                                                                                    DOVER URG-LEBAN
                                                                                       YOLO AMENTO-
                                       Ro                                                                                                                                                                                                                                       LINCOLN
                               San Fr sa                                                                                                                   PROVO-OREM                                                                                                                                                                                            DECATUR            TERRE
                                                                                                                                                                                                                                                                                                                                                                                                                                                                 CU        GTON
                                                                                                                                                                                                                                                                                                                                              BLOOMINGTON-                                                                          i
                                                                                                                                                                                                                                                                                                                                                                                                                         Cincinnat TI-                         WASHIN ORE                                                       HARRISB
                                                                                                                                                                                                                                                                                                                                                                                                                                                 DAYTON-FIELD BALTIM ton
                                      ancisco                                                                                                                                                                                                                                                                                                                                       HAUTE
                              SA  N FRAN                                                                                                                                               Boulder-Longmont                                                                                                                                          NORMAL                                                                    CINCINNA                                                                                            YORK ore           BURG
                                        CI                                                                                                                                     DENVER-BOULDER-GREELEY                                                                                                           ST. JOSEPH                                             CHAMPAIGN-                                            HAMILTON            SPRING            Washing                                                    Baltim D-PETERS
                                  OAKLAN SCO-                       STOCKTON
                                                                                                                                                                                                                                                                                                                                                                          URBANA                                                                                                                                              RICHM  ON                        WS
                                  SAN JO D-                                 -LO
                                                                     MODESTO DI                                                                                                                                               Denver                                                                                 KANSAS CITY                      SPRINGFIELD                                                                                                    TTESVILLE                                                                        PORT NE
                                        SE                                                                                                                                                                                                                                                                                       COLUMBIA                                   INDIANAPOLIS MINGTON                                                             CHARLO                                                                           ACH-NEW
                                                                       MERCED                                                                                                                                                                                                                                                                                                        BLOO                                                                                                                                             INIA BE
                                     Oaklan                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     K-VIRG
                                             d                                         FRESNO                                                                                                                                                                                                                                                                                        EVANSVILLE-                                                   RLESTON                                                             NORFOL
                                       San Jo                                                                                                                                                                             COLORADO                                                         TOPEKA                                                                                    HENDERSON                                           N- CHA ANOKE
                                    Santa Cr
                                              se                                                                                                                                     GRAND JUNCTION                                                                                                                                                                                                                          HUNTINGTO              RO         RO--                          RG
                                                                                                                                                                                                                           SPRINGS                                                           LAWRENCE                                                                                                                           ASHLAND             GREENSBO M--                   LYNCHBU                  L HILL
                                    Watson uz-                                            VISALIA-                                                                                                                                                                                                                                                                                                                                                        N-SALE                            E
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   DANVILLURHAM- CHAPE Y
                                           ville                                                                                                                                                                                                                                                                                                                                                   LOUISVILLE           NGTON                    WINSTOHIGH POINT
                                                                                           TULARE-                                                                                                                                                                                                                                            ST. LOUIS                                              Hamilton- n LEXI                                                                                  ROCK UNT
                                                                                          PORTERVIL                                                                                                                      PUEBLO
                                                                                                                                                                                                                                                                                                                                                                                                                                                       HICKORY N-                RALEIGH-D
                                                SALINAS
                                                                                                   LE               LAS VEGAS                                                                                                                                                                                                                                                        OWENSBORO Middletow                    CITY-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          MO EENVILLE
                                                                                             BAKERSFIE                                                                                                                                                                                         WICHITA                       SPRINGFIELD                                                                          JOHNSON OL
                                                                                                                                                                                                                                                                                                                                                                                                                          RIST                       MORGANTO                                                GR
                                          SAN LUI
                                                 S OB                                                 LD                                                                                                                                                                                                          JOPLIN                                                                                     KINGSPORT-B                               LENOIR
                                            ATASCADE ISPO-                                         Riverside
                                                                                                San Bernar -                                                                                                                                                                                                                                                            CLARKSVILLE-                                                                                                                            ORO
                                           PASO RO RO-                                                     dino                                            FLAGSTAFF                                                                                                                                                                                                    HOPK INSVILLE                    NASHVILLE                                                                                     GOLDSB
                                                   BLES                                                                                                                                                                                                                                                                                                                                                                                                                           TTE-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                         CHARLO IA-
                                              SANTA BAR                                                                                                                                                                                                                                                                                                                                                          KNOXVILLE                                                 GASTON L                                     VILLE
                                               SANTA MABARA-                                                                                                                                                                                                             ENID                                             FAYETTEVILLE-                                                                                            ASHEVILLE                                ROCK HIL FAYETTEVILLE              JACKSON
                                                 LOMPOCRIA-                                                                                                                                                                                                                                               TULSA
                                                                                                                                                                                                                                                                                                                          SPRINGDALE-       JONESBORO                          JACKSON              CHA TTANOOGA                                                       -            CE                              TON
                                                                                                                                                                           ALBUQUERQUE                                                                                                                                    ROGERS         LITTLE ROCK-                                                                                                      GREENVILLE FLOREN                              WILMING
                                                                                                                                                                                                                                                                                                                                                                                              HUNTSVILLE                                                          RG-
                                            LOS ANGE                                                                                                                                                       SANTA FE                                                                                                                   NORTH LITTLE ROCK                        FLORENCE                                                               SPARTANBU
                                             RIVER LES-              Ventura                                                                                                                                                                                                                                                                                                                                                     ATLA NTA         AND  ERSON                                     MYRTLE                                                     LEGEND
                                          ORANGE SIDE-                                                                                                                                                                                       AMARILLO                                        OKLAHOMA         FORT                                                   MEMPHIS                                                                                                  SUMTER              BEACH
                                                  COUNTY                                                                                                                                                                                                                                        CITY                                                                                                    GADSDEN                                                                                                                           AMARILLO                 Metropolitan Statistical Area (MSA)
                                                                                                                                                                                                                                                                                                             SMITH                                                                                                                          ATHENS                 COLUMBIA
                                                                                                                                                                                                                                                                                                                                                                                            DECATUR                                                                                                  ON-                     PORTLAND-SALEM                        Consolidated Metropolitan Statistical Area (CMSA)
                                                                                                                                                                                                                                                                                LAWTON                                                                                                     INGHAM                                                                                          CHARLEST ESTON
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   ARL                                        Yolo                 Primary Metropolitan Statistical Area (PMSA)
                                                                                                                             YUMA                                                                                                                                                                                               PINE BLUFF                                            BIRM                                                                                                       CH
                                                                                Orange                                                          PHOENIX-MESA                                                                                                                                SHERMAN-                                                                                                                                                AUGUSTA-                            NORTH
                                                                       Los AngelCounty                                                                                                                                                                                                       DENISON                                                                                                         ANNISTON                                 AIKEN                                                                                                        State
                                                                       Long Be es-                                                                                                                                                                      WICHITA FALLS                                                  TEXARKANA-TEXARKANA                                                                     AUBURN- COLUMBUS                                                                                                                                    Metropolitan county or county equivalent
                                                                              ach                                                                                                                                                                                                                                                                                                                               OPELICA
                                                                                           SAN DIEGO                                                                                                                                         LUBBOCK                                               Dallas                                                                                        SA                                           MACON
                                                                                                                                                                                                                                                                                                       LONGVIEW-                                                                        TUSCALOO                                                                             SAVANNAH
                                                                                                                                                                                                                                                           DALLAS-FORT WORTH                           MARSHALL                                MONROE                   JACKS ON
                                                                                                                                                                                                                                                                                                                                                                                                           Y                                                                                                                          0          100         200        300     400 Kilometers
                                                                                                                                                                                                 LAS CRUCES                                           Fort Worth-Arlington                                                                                                                   MONTGOMER                                    ALBANY
                                                                                                                                                        TUCSON                                                                                                                                                                                                                                                      DOTHAN
                                                                                                                                                                                                                                                                ABILENE                                                                                                                                                                                                                                                               0                 100               200           300 Miles
                                                                                                                                                                                                                                ODESSA-MIDLAND                                                                               SHREVEPORT-                                                                                                                                               LLE
                                                                                                                                                                                                                                                                                                            TYLER             BOSSIER CITY                            HATTIESBURG         MOBILE                                                                           JACKSONVI                                                                     1:13,500,000
                                                                                                                                                                                                      EL PASO                                                                                WACO                                        ALEXANDRIA                                                PENSACOLA
                                                                                                                                                                                                                                                          SAN ANGELO                                                                                                                                              FORT WALTON               TALLAHASSE
                                                                                                                                                                                                                                                                                                                                                                                                                                                        E
                                                                                                                                                                                                                                                                                                                                                                                                                   BEACH                                    E
                                                                                                                                                                                                                                                                                                                                                         BATON ROUGE                                                                            GAINESVILL
                                                                                                                                                                                                                                                                KILLEEN-TEMPLE                 BRYAN-COLLEGE STATION
                                                                                                                                                                                                                                                                                                                                   LAKE                                                                                                                                            DAYTON   A BEACH
                                                                                                                                                                                                                                                                                                                                  CHARLES                                                                   PANAMA CITY                                  OCALA
                                                                                                                                                                                                                                                           AUSTIN-SAN MARCOS                                                                                                                             T-
                                                                                                                                                                                                                                                                                                                                                                                         BILOXI-GULFPOR                                                                                                           LLE-PALM
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             BAY
                  HAWAII                                                                                                                                                                                                                                                                                                                       LAFAYETTE                                    PASCAGOULA                                                                                                  E-TITUSVI
                                                                                                                                                                                                                                                                                                                                                                                                                                                    ORLAND
                                                                                                                                                                                                                                                                                                                                                                                                                                                            O                               MELBOURN
                                                                                                                                                                                                                                                              SAN ANTONIO                   Houston
                                                                                                                                                                                                                                                                                                                           BEAUMONT-                                                 NEW ORLEANS                                                      RWATER
                                                                                                                                                                                                                                                                                                                               ARTHUR                                                                                                PETERSBURG-CLEA                                                                    ST. LUCIE
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      PUERTO RICO
                                                                                                                                                                                                                                                                                         VICTORIA                        PORT                                     HOUMA                                                  TAMPA-ST.                                                                            RCE-PORT
                                                                                                                                                                                                                                                                                                                    Galveston-Texas City                                                                                                                                             ND-            FORT PIE                                                                  SAN JUAN-CAGUAS-ARECIBO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              LAKELAHAVEN                                  -
                                                 HONOLULU
                                                                                                                                                                                                                                                                                                 Brazoria
                                                                                                                                                                                                                                                                                                               HOUSTON-GALVESTON-BRAZORIA                                                                                                                                   WINTER                               M BEACH
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       WEST PAL ON                                          AGUADILLA          Arecibo         San Juan-Bayamón
                                                                                                                                                                                                                                                                                                                                                                                                                                                       RADENTON                                         BOCA RAT uderdale
                                                                                                                                                                                                                                                            LAREDO        CORPUS CHRISTI                                                                                                                                                   SARASOTA-B              DA                                    Fort La
                                                                                                                                                                                                                                                                                                                                                                                                                                                       PUNTA GOR                                                 I-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                         AL                              MIAM LAUDERDALE                                                        PONCE
                                                                                                                                                                                                                                                                                                                                                                                                                                                         ERS -CAPE COR                                    FO  RT
                                                                                                                                                                                                                                                                                                                                                                                                                                                FORT MY                  NAPLES
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      MAYAGÜEZ
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Miami                                                                                Caguas
                                                                                                                                                                                                                                                                        McALLEN-
                       0     100         200      300 Kilometers                                                                                                                                                                                                    EDINBURG-MISSION                                                                                                                                                                                                                                                     0 20 40 Kilometers

                       0            100
                                 200 Miles
                                                           Metropolitan Area boundaries and names are those defined by the
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        0        20        40 Miles
                            1:15,000,000                   Federal Office of Management and Budget on June 30, 1999. All                                                                                                                                                                        BROWNSVILLE-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1:5,000,000
                                                                                                                                                                                                                                                                                                HARLINGEN-SAN BENITO
                                                           other boundaries and names are as of June 30, 1999.
                 U.S. DEPARTMENT OF COMMERCE, Economics and Statistics Administration, Bureau of the Census




                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       15
16
Measures constructed




                       17
Measures constructed
        Idea                  Measure

      Innovation         Patent applications

   Entrepreneurship   Establishment births, 0-19

     VC Activity          Investment count


    R&D Funding           All federal funding



                                                   17
Identification procedure


   Innovation/
                       VC Activity   LP Returns
      E’ship




                 ???




                                                  18
Identification procedure


   Innovation/
                       VC Activity   LP Returns
      E’ship




                 ???




                                                  18
INVESTECO PRIVATE
                     EQUITY FUND III
                         Limited partners

                    $




                        Portfolio companies
General partners    $




                                              19
Portfolio Asset Allocation

                                     12%
  Limited partners
                              13%
                                                   41%




                                    34%




                     Stocks         Bonds   Cash     Alternative




                                                                   20
Instrumental Variable:
Portfolio Rebalancing
                      ¯
               IVit = Rt × Ni

                  Nationwide    Count of institutional
                  avg returns    investors in region


      Year FE remove macro-level economic effects

      Use of industry average return and MSA FE
      remove regional effects



                                                         21
Population (thousands)                659.4     1104.9     3270
                Patents                               246.8      583.0     3270
                Patent Citations (5yr)               1228.2     3671.0     2614
                Births of Establishments, 0-19       1415.2     2523.6     3270
                R&D Support (millions)                 49.6      122.6     3270
                VC Investment Count                    15.9      106.4     3270


Innovation
                VC Investment Amount (millions)        39.8      340.1     3270




                               Table 2: Effects on Innovation
                                     (1)         (2)         (3)          (4)          (5)         (6)
                                  Patents     Patents     Citations    Patents      Patents     Citations
   Population (t-1)               1.427∗∗∗    1.405∗∗∗    1.721∗∗∗     1.453∗∗∗     1.444∗∗∗    1.719∗∗∗
                                   (4.81)      (4.71)      (3.45)       (4.90)       (4.87)      (3.46)
   R&D Support (t-1)             -0.000460   0.0202∗∗     0.0207∗∗    -0.000410     0.00720     0.0145∗∗
                                   (-0.19)     (2.19)      (2.00)       (-0.17)      (1.53)      (2.00)
   VC Count (t)                   0.0231∗    0.0261∗∗     -0.00568
                                   (1.83)      (2.05)      (-0.37)
   VC Count (t) x R&D (t-1)                  0.00764∗∗    0.00636∗
                                               (2.27)      (1.78)
   VC Amount (t)                                                         0.000643    0.00143    0.000229
                                                                          (0.42)      (0.89)      (0.11)
   VC Amount (t) x R&D (t-1)                                                        0.000452∗   0.000654∗
                                                                                      (1.71)      (1.73)
   Time period                     1993-2002 1993-2002 1993-2000 1993-2002 1993-2002 1993-2000
   Year Dummies                       Yes         Yes         Yes         Yes          Yes     Yes
   MSA Fixed Effects                   Yes         Yes         Yes         Yes          Yes     Yes
     2
   R                                  0.16        0.16        0.15        0.15         0.15    0.15
   Clusters                           328          328        328         328          328     328
   Observations                      3270         3270        2624        3270         3270    2624
  Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in
  parentheses; disturbances clustered by MSA.



                                                37                                                          22
Entrepreneurship
                               Table 3: Effects on Entrepreneurship
                                               (7)         (8)         (9)        (10)
                                             Births      Births      Births      Births
           Population (t-1)                 0.820∗∗∗    0.815∗∗∗    0.825∗∗∗    0.821∗∗∗
                                            (10.43)     (10.25)     (10.55)     (10.45)
           R&D Support (t-1)               -0.000679    0.00413    -0.000658    0.00319
                                             (-1.04)     (1.54)      (-1.01)     (1.34)
           VC Count (t)                    0.0100∗∗∗   0.0107∗∗∗
                                             (2.97)      (3.12)
           VC Count (t) x R&D (t-1)                    0.00178∗
                                                         (1.89)
           VC Amount (t)                                           0.00101∗∗   0.00141∗∗∗
                                                                     (2.57)      (3.21)
           VC Amount (t) x R&D (t-1)                                           0.000229∗
                                                                                 (1.73)
           Year Dummies                       Yes         Yes        Yes        Yes
           MSA Fixed Effects                   Yes         Yes        Yes        Yes
             2
           R                                  0.22       0.22        0.22       0.22
           Clusters                           328         328        328        328
           Observations                      3270        3270       3270        3270
    Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in
    parentheses; disturbances clustered by MSA.



                                                                                                   23
Robustness
            Table 4: Robustness to Removing San Francisco Bay Area and Boston
                                         Excluding Bay Area      Excluding Boston
                                           (11)        (12)        (13)        (14)
                                         Patents      Births     Patents      Births
           Population (t-1)              1.421∗∗∗   0.813∗∗∗     1.409∗∗∗    0.816∗∗∗
                                          (4.75)     (10.22)      (4.72)     (10.27)
           R&D Support (t-1)              0.0138     0.00398    0.0194∗∗     0.00388
                                          (1.60)      (1.45)      (2.10)      (1.43)
           VC Count (t)                   0.0190    0.0101∗∗∗    0.0254∗∗   0.0104∗∗∗
                                          (1.56)      (2.89)      (1.99)      (3.05)
           VC Count (t) x R&D (t-1)      0.00529∗   0.00173∗    0.00736∗∗   0.00169∗
                                          (1.68)      (1.79)      (2.17)      (1.77)
           Year Dummies                    Yes         Yes        Yes        Yes
           MSA Fixed Effects                Yes         Yes        Yes        Yes
           R2                              0.15        0.22       0.16       0.22
           Clusters                         324        324        327        327
           Observations                    3230       3230        3260      3260
  Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in
  parentheses; disturbances clustered by MSA.

                               Table 5: Innovation by Agencies
       Source of R&D Support          HHS        NSF         DoD        DoA       NASA           24
                                      (15)       (16)       (17)       (18)       (19)
                                     Patents    Patents    Patents    Patents    Patents
VC Count (t) x R&D (t-1)      0.00529     0.00173     0.00736      0.00169
                                          (1.68)      (1.79)       (2.17)      (1.77)
           Year Dummies                    Yes         Yes        Yes        Yes
           MSA Fixed Effects                Yes         Yes        Yes        Yes
           R2                              0.15        0.22       0.16       0.22

Innovation by Agency
           Clusters
           Observations
                                            324
                                           3230
                                                       324
                                                      3230
                                                                  327
                                                                  3260
                                                                             327
                                                                            3260
  Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in
  parentheses; disturbances clustered by MSA.

                               Table 5: Innovation by Agencies
       Source of R&D Support          HHS          NSF         DoD          DoA    NASA
                                  (15)            (16)       (17)         (18)     (19)
                                Patents         Patents    Patents     Patents Patents
       Population (t-1)         1.411∗∗∗        1.403∗∗∗   1.397∗∗∗    1.441∗∗∗ 1.425∗∗∗
                                 (4.77)          (4.71)     (4.71)       (4.85)   (4.77)
       R&D Support (t-1)        0.00997        0.0135∗∗    0.0119∗∗    -0.00108 0.00888∗
                                 (1.57)          (2.30)     (2.25)      (-0.52)   (1.85)
       VC Count (t)             0.0272∗∗       0.0267∗∗    0.0308∗∗     0.0250∗  0.0258∗
                                 (2.09)          (2.08)     (2.28)       (1.75)   (1.94)
       VC Count (t) x R&D (t-1) 0.00245        0.00543∗∗   0.00348∗    0.000502 0.00142
                                 (1.09)          (2.41)     (1.82)       (0.51)   (0.74)
       Year Dummies                    Yes        Yes        Yes        Yes        Yes
       MSA Fixed Effects                Yes        Yes        Yes        Yes        Yes
       R2                             0.16        0.16       0.16       0.16      0.16
       Clusters                        328        328        328        328        328
       Observations                   3270       3270       3270        3270      3270
  Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in
  parentheses; disturbances clustered by MSA.

                                                   39
                                                                                                 25
Entrepreneurship by Agency
                           Table 6: Entrepreneurship by Agencies
    Source of R&D Support           HHS           NSF         DoD           DoA        NASA
                                (20)             (21)          (22)        (23)          (24)
                               Births           Births        Births     Births        Births
    Population (t-1)          0.817∗∗∗         0.812∗∗∗      0.814∗∗∗   0.822∗∗∗      0.820∗∗∗
                              (10.33)          (10.23)       (10.32)     (10.34)       (10.41)
    R&D Support (t-1)         0.00146        0.00426∗∗∗      0.00211    0.000191     -0.000157
                               (1.07)           (2.76)        (1.42)      (0.31)       (-0.10)
    VC Count (t)             0.0104∗∗∗        0.0111∗∗∗     0.0113∗∗∗   0.0113∗∗∗    0.00967∗∗∗
                               (2.94)           (3.23)        (3.07)      (3.11)        (2.67)
    VC Count (t) x R&D (t-1) 0.000295        0.00161∗∗∗     0.000614    0.000312     -0.000138
                               (0.64)           (2.77)        (1.19)      (1.24)       (-0.25)
     Year Dummies                    Yes           Yes         Yes          Yes         Yes
     MSA Fixed Effects                Yes           Yes         Yes          Yes         Yes
     R2                              0.22          0.22        0.22         0.22        0.22
     Clusters                        328           328         328          328         328
     Observations                   3270          3270        3270          3270       3270
  Notes: OLS regression results; * p < 0.10, **   p < 0.05, *** p < 0.01.   Robust t-statistics in
  parentheses; disturbances clustered by MSA.



                                                                                                     26
Table 7: Lag Structure of R&D Effects on Innovation
                                (25)       (26)        (27)        (28)        (29)         (30)
                              Patents    Patents     Patents     Patents     Patents      Patents
 Population (t-1)             1.418∗∗∗   1.405∗∗∗    1.405∗∗∗    1.398∗∗∗    1.415∗∗∗     1.418∗∗∗
                               (4.77)     (4.71)      (4.71)      (4.71)      (4.77)       (4.75)
 VC Count (t)                 0.0239∗    0.0261∗∗    0.0263∗∗    0.0270∗∗    0.0261∗∗     0.0253∗∗
                               (1.88)     (2.05)      (2.06)      (2.11)      (2.05)       (2.00)
 R&D Support (t)              0.00803
                               (0.85)
 VC Count (t) x R&D (t)       0.00246
                               (0.71)
 R&D Support (t-1)                       0.0202∗∗
                                           (2.19)
 VC Count (t) x R&D (t-1)                0.00764∗∗
                                           (2.27)
 R&D Support (t-2)                                   0.0190∗∗
                                                       (2.23)
 VC Count (t) x R&D (t-2)                            0.00689∗∗
                                                       (2.20)
 R&D Support (t-3)                                               0.0221∗∗
                                                                   (2.41)
 VC Count (t) x R&D (t-3)                                        0.00809∗∗
                                                                   (2.38)
 R&D Support (t-4)                                                            0.0174∗
                                                                               (1.81)
 VC Count (t) x R&D (t-4)                                                    0.00733∗∗
                                                                               (2.11)
 R&D Support (t-5)                                                                        0.0157
                                                                                           (1.60)
 VC Count (t) x R&D (t-5)                                                                0.00761∗∗
                                                                                           (2.13)
 Year Dummies                    Yes        Yes         Yes        Yes          Yes            Yes
 MSA Fixed Effects                Yes        Yes         Yes        Yes          Yes            Yes
 R2                             0.16       0.16        0.16        0.16         0.16           0.16
 Clusters                        328        328         328        328          328            328
 Observations                   3270       3270        3270       3270         3270            3270
Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust   t-statistics   in
parentheses; disturbances clustered by MSA.



                                                41                                                    27
Table 8: Lag Structure of R&D Effects on Entrepreneurship
                                  (31)       (32)        (33)        (34)        (35)          (36)
                                Births     Births       Births     Births       Births        Births
 Population (t-1)              0.821∗∗∗   0.815∗∗∗     0.815∗∗∗   0.813∗∗∗     0.811∗∗∗      0.812∗∗∗
                                (10.49)    (10.25)     (10.23)     (10.18)     (10.11)       (10.15)
 VC Count (t)                 0.0101∗∗∗   0.0107∗∗∗   0.0105∗∗∗   0.0107∗∗∗   0.0108∗∗∗     0.0107∗∗∗
                                 (2.97)     (3.12)      (3.07)      (3.12)      (3.15)        (3.13)
 R&D Support (t)              -0.000782
                                (-0.34)
 VC Count (t) x R&D (t)        0.000329
                                 (0.40)
 R&D Support (t-1)                        0.00413
                                           (1.54)
 VC Count (t) x R&D (t-1)                 0.00178∗
                                           (1.89)
 R&D Support (t-2)                                    0.00382∗
                                                       (1.67)
 VC Count (t) x R&D (t-2)                             0.00128
                                                       (1.56)
 R&D Support (t-3)                                                 0.00444∗
                                                                    (1.81)
 VC Count (t) x R&D (t-3)                                          0.00154∗
                                                                    (1.78)
 R&D Support (t-4)                                                            0.00588∗∗
                                                                                (2.20)
 VC Count (t) x R&D (t-4)                                                     0.00188∗
                                                                                (1.95)
 R&D Support (t-5)                                                                          0.00602∗
                                                                                             (1.94)
 VC Count (t) x R&D (t-5)                                                                   0.00193∗
                                                                                             (1.74)
 Year Dummies                     Yes        Yes           Yes        Yes          Yes          Yes
 MSA Fixed Effects                 Yes        Yes           Yes        Yes          Yes          Yes
 R2                              0.22        0.22         0.22       0.22         0.22          0.22
 Clusters                         328        328           328        328          328          328
 Observations                    3270        3270         3270       3270         3270         3270
Notes: OLS regression results; * p < 0.10, ** p < 0.05,   *** p < 0.01. Robust   t-statistics in
parentheses; disturbances clustered by MSA.



                                                42                                                      28
Table 9: Lag Structure of Venture Capital Effects on Innovation and Entrepreneurship
                                   (37)           (38)       (39)         (40)        (41)           (42)
                                 Patents        Patents    Patents       Births      Births         Births
 Population (t-1)                1.405∗∗∗       1.414∗∗∗   1.420∗∗∗     0.815∗∗∗    0.815∗∗∗       0.818∗∗∗
                                  (4.71)         (4.73)     (4.77)      (10.25)     (10.15)        (10.17)
 R&D Support (t-1)              0.0202∗∗                                0.00413
                                  (2.19)                                 (1.54)
 VC Count (t)                   0.0261∗∗                               0.0107∗∗∗
                                  (2.05)                                 (3.12)
 VC Count (t) x R&D (t-1)       0.00764∗∗                              0.00178∗
                                  (2.27)                                 (1.89)
 R&D Support (t-2)                          0.0247∗∗∗                               0.00177
                                              (2.80)                                 (0.49)
 VC Count (t-1)                               0.0195                               0.0108∗∗∗
                                              (1.60)                                 (2.59)
 VC Count (t-1) x R&D (t-2)                 0.00894∗∗∗                             0.000520
                                              (2.83)                                 (0.40)
 R&D Support (t-3)                                         0.0298∗∗∗                            0.00239
                                                             (3.67)                              (0.70)
 VC Count (t-2)                                             0.0145                             0.00837∗
                                                             (1.22)                              (1.92)
 VC Count (t-2) x R&D (t-3)                                0.0109∗∗∗                           0.000782
                                                             (3.73)                              (0.63)
 Year Dummies                      Yes            Yes        Yes           Yes        Yes           Yes
 MSA Fixed Effects                  Yes            Yes        Yes           Yes        Yes           Yes
 R2                                0.16          0.16        0.16         0.22       0.22           0.22
 Clusters                           328           328        328           328        328           328
 Observations                      3270          3270        3270         3270       3270           3270
Notes: OLS regression results; * p < 0.10, **   p < 0.05, *** p < 0.01.   Robust t-statistics in
parentheses; disturbances clustered by MSA.


                                                                                                              29
Instrumental Variables
       Table 10: Instrumental Variables Estimation for Innovation and Entrepreneurship
                                                  (43)          (44)       (45)        (46)
                                    1st Stage   Patents       Patents     Births      Births
      Population (t-1)               1.116∗∗    1.330∗∗∗      1.368∗∗∗   0.803∗∗∗    0.813∗∗∗
                                      (2.45)     (4.71)        (4.85)     (9.32)      (9.13)
      LP Returns                    0.0112∗∗∗
                                     (10.49)
      R&D Support (t-1)             0.000791    -0.000617     0.0265∗    -0.000706   0.00664
                                      (0.60)      (-0.22)      (1.89)      (-0.98)     (1.60)
      VC Count (t)                              0.0957∗∗∗     0.0814∗∗    0.0227∗∗    0.0189∗
                                                  (3.23)       (2.57)      (2.35)      (1.95)
      VC Count (t) x R&D (t-1)                               0.00974∗∗               0.00264∗
                                                               (1.98)                  (1.83)
       Year Dummies                    Yes          Yes         Yes        Yes         Yes
       MSA Fixed Effects                Yes          Yes         Yes        Yes         Yes
       R2                              0.27
       Clusters                         328          328         328        328        328
       Observations                    3270         3270        3270        3270      3270
   Notes: 2SLS regression results; * p < 0.10, **   p < 0.05, *** p < 0.01. Bootstrapped
   t-statistics in parentheses.



                                                                                                30
Venture capital as catalyst to
commercialization



  Increased innovation

  Increased entrepreneurship




                                 31
Further results




   Non-compete covenants   Social capital




                                            32
End note:
Key to getting funding




                         33
End note:
Key to getting funding




                         33
End note:
Key to getting funding




                         33
End note:
Key to getting funding




   Applied Physics Research




                              33
Thank you




            34

Vce tkk 2010 06-14

  • 1.
    Venture Capital asa Catalyst to Commercialization Sampsa Samila and Olav Sorenson 1
  • 2.
  • 3.
    $241 billion invested in researchby OECD governments in 2007 2
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
    12 10 Log of Patents 1993-2002 4 6 2 8 5 10 15 20 25 Log of Federal R&D Support 1993-2002 Log of Patents 1993-2002 Fitted values 5
  • 9.
    12 Logof Count of Startups 1993-2002 7 8 9 10 11 5 10 15 20 25 Log of Federal R&D Support 1993-2002 Log of Startups 1993-2002 Fitted values 6
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
    Solution to agencyproblems 11
  • 20.
    INVESTECO PRIVATE EQUITY FUND III Limited partners $ ve ry ity l! tiv a c c Portfolio companies A lo General partners $ 12
  • 21.
    12 Log of Patents1993-2002 4 6 2 8 10 5 10 15 20 25 Log of Federal R&D Support 1993-2002 MSAs with VC MSAs without VC Fitted values Fitted values 13
  • 22.
    12 Log ofCount of Startups 1993-2002 7 8 9 10 11 5 10 15 20 25 Log of Federal R&D Support 1993-2002 MSAs with VC MSAs without VC Fitted values Fitted values 14
  • 23.
    Empirical Setting Metropolitan Metropolitan Areas of the United States and Puerto Rico: 1999 ALASKA INSET 0 50 100 Kilometers 0 300 600 900 Kilometers Manchester United States 0 50 100 Miles 0 300 600 Miles 1:6,000,000 Portsmouth-Rochester 1:45,000,000 Fitchburg- Nashua Leominster Lowell Lawrence Worcester SPRINGFIELD BOSTON-WORCESTER- ANCHORAGE LAWRENCE PITTSFIELD Boston HARTFORD Brockton Waterbury Danbury BARNSTABLE-YARMOUTH Stamford- BELLI Norwalk New Bedford SEATTL E-TACOM NGHAM NEW LONDON- 1993 - 2002 Bremer A-BREME PROVIDENCE- ton New Haven- NORWICH FALL RIVER-WARWICK Seatt RTON Bridgeport Meriden le- Bellevu SPOKANE NEW YORK-NORTHERN NEW JERSEY- Everette- LONG ISLAND (PART) Olym pia YAKIMA RICHLAND MISSOULA BANGOR -KENN Tacom PASCO EWICK- GREAT FALLS a GRAND FORKS GTON BURLIN BISMARCK BURN Portlan ON-AU d-Vanc ME LEWIST PORT ouver UTICA-RO BANY- Y- AL CTAD PORTLA ND LAND-S CORVALL Salem ALEM DULUTH-SUPERIOR SCHENEOY GLENS IS FARGO-MOORHEAD TR FALLS SAGINAW- - EUGENE BILLINGS BAY CITYD SET -SPRIN GFIELD ST. CLOUD EAU CLAIRE WAUSAU GREEN BAY MIDLAN SYRACU SE SEE IN DS- TER GRAND RAPI ROCHES MINNEAPOLIS- MUSKEGON- R-FLINT NN ARBO k ST. PAUL HOLLAND Newar burgh KOSH- APPLETON-OSH AH LANSING- G DETROIT-ADetroit BUFFALO - AMTON New ses ic -Passa NEEN Flint or FALLS BINGH Dutchnty BergenSuffolk ISLAND MEDFOR EAST LANSIN Ann Arb NIAGARA Cou u- Nassa rk -LONG BOISE CITY ROCHESTER SHEBOYGAN ELMIRA D-ASHLAN INE JACKSON D- AKRO N ES- --WILK N New ty Yo JERSEY D RAPID CITY LA CROSSE MILWAUKEE-RAC sha SOUTH CLEVELAN WARREN OWN RANTON ETO JAMEST T SCBARRE--HAZL Ci Jersey-NORTHER rdon N NEW POCATELLO SIOUX FALLS Milw aukee-Wauke BEND YOUNGSTO WN- SPOR unte CASPER MADISON Racine eveland- Cl n- WILLIAM NEex YORK W-Somerset-HSTON - JANESVILLEIT Kenosha Lorai ERIE STATEGE es LEHEM- EA DUBUQUE LLE Middl OWN-BETH RENO WATERLOO- BELO BENTON ElyriaAkron SHARON COGH ROCKFORD HARBOR KALAMAZOO- PITTSBUR N LANCAST ER ALLENT n to CEDAR FALLS BATTLE TrenING -Ocean REDDING Chicago CREEK JOHNSTOW READ outh SIOUX CITY CANTON- Monm lphia C CITY CHICO-PA RADISE Sacra CEDAR RAPIDS DES CHICAGO- ART- TOLEDO MASSILLON Philade ape May INGTON-A TLANTI mento GARY- ELKH LIMA ALTOONA own tic-C M Vallejo- YUBA CHEYENNE MOINES KENOSHA Gary GOSHEN LD LLE- Hagerst Atlan PHIA-WIL ridgeton Fairfiel CITY OMAHA IOWA CITY FORT WAYNE MANSFIE STEUBENVI EL illville-B Napa d- SALT LAKE CITY- DAVEN PORT- Kankakee LAFAYETTE OMO COLUM BUS WEIRTON PHILAD d-M-Newark OGDEN MOLINE- PEORIA- KOK RG- Vinelangton Yolo FORT COLLINS-LOVELAND PEKIN WHEELINGPARKERSBU Wilm in ISLE Santa SACR ROCK ISLAND MARIETTA MBERLAND - ON-CARL Greeley MUNCIE DOVER URG-LEBAN YOLO AMENTO- Ro LINCOLN San Fr sa PROVO-OREM DECATUR TERRE CU GTON BLOOMINGTON- i Cincinnat TI- WASHIN ORE HARRISB DAYTON-FIELD BALTIM ton ancisco HAUTE SA N FRAN Boulder-Longmont NORMAL CINCINNA YORK ore BURG CI DENVER-BOULDER-GREELEY ST. JOSEPH CHAMPAIGN- HAMILTON SPRING Washing Baltim D-PETERS OAKLAN SCO- STOCKTON URBANA RICHM ON WS SAN JO D- -LO MODESTO DI Denver KANSAS CITY SPRINGFIELD TTESVILLE PORT NE SE COLUMBIA INDIANAPOLIS MINGTON CHARLO ACH-NEW MERCED BLOO INIA BE Oaklan K-VIRG d FRESNO EVANSVILLE- RLESTON NORFOL San Jo COLORADO TOPEKA HENDERSON N- CHA ANOKE Santa Cr se GRAND JUNCTION HUNTINGTO RO RO-- RG SPRINGS LAWRENCE ASHLAND GREENSBO M-- LYNCHBU L HILL Watson uz- VISALIA- N-SALE E DANVILLURHAM- CHAPE Y ville LOUISVILLE NGTON WINSTOHIGH POINT TULARE- ST. LOUIS Hamilton- n LEXI ROCK UNT PORTERVIL PUEBLO HICKORY N- RALEIGH-D SALINAS LE LAS VEGAS OWENSBORO Middletow CITY- MO EENVILLE BAKERSFIE WICHITA SPRINGFIELD JOHNSON OL RIST MORGANTO GR SAN LUI S OB LD JOPLIN KINGSPORT-B LENOIR ATASCADE ISPO- Riverside San Bernar - CLARKSVILLE- ORO PASO RO RO- dino FLAGSTAFF HOPK INSVILLE NASHVILLE GOLDSB BLES TTE- CHARLO IA- SANTA BAR KNOXVILLE GASTON L VILLE SANTA MABARA- ENID FAYETTEVILLE- ASHEVILLE ROCK HIL FAYETTEVILLE JACKSON LOMPOCRIA- TULSA SPRINGDALE- JONESBORO JACKSON CHA TTANOOGA - CE TON ALBUQUERQUE ROGERS LITTLE ROCK- GREENVILLE FLOREN WILMING HUNTSVILLE RG- LOS ANGE SANTA FE NORTH LITTLE ROCK FLORENCE SPARTANBU RIVER LES- Ventura ATLA NTA AND ERSON MYRTLE LEGEND ORANGE SIDE- AMARILLO OKLAHOMA FORT MEMPHIS SUMTER BEACH COUNTY CITY GADSDEN AMARILLO Metropolitan Statistical Area (MSA) SMITH ATHENS COLUMBIA DECATUR ON- PORTLAND-SALEM Consolidated Metropolitan Statistical Area (CMSA) LAWTON INGHAM CHARLEST ESTON ARL Yolo Primary Metropolitan Statistical Area (PMSA) YUMA PINE BLUFF BIRM CH Orange PHOENIX-MESA SHERMAN- AUGUSTA- NORTH Los AngelCounty DENISON ANNISTON AIKEN State Long Be es- WICHITA FALLS TEXARKANA-TEXARKANA AUBURN- COLUMBUS Metropolitan county or county equivalent ach OPELICA SAN DIEGO LUBBOCK Dallas SA MACON LONGVIEW- TUSCALOO SAVANNAH DALLAS-FORT WORTH MARSHALL MONROE JACKS ON Y 0 100 200 300 400 Kilometers LAS CRUCES Fort Worth-Arlington MONTGOMER ALBANY TUCSON DOTHAN ABILENE 0 100 200 300 Miles ODESSA-MIDLAND SHREVEPORT- LLE TYLER BOSSIER CITY HATTIESBURG MOBILE JACKSONVI 1:13,500,000 EL PASO WACO ALEXANDRIA PENSACOLA SAN ANGELO FORT WALTON TALLAHASSE E BEACH E BATON ROUGE GAINESVILL KILLEEN-TEMPLE BRYAN-COLLEGE STATION LAKE DAYTON A BEACH CHARLES PANAMA CITY OCALA AUSTIN-SAN MARCOS T- BILOXI-GULFPOR LLE-PALM BAY HAWAII LAFAYETTE PASCAGOULA E-TITUSVI ORLAND O MELBOURN SAN ANTONIO Houston BEAUMONT- NEW ORLEANS RWATER ARTHUR PETERSBURG-CLEA ST. LUCIE PUERTO RICO VICTORIA PORT HOUMA TAMPA-ST. RCE-PORT Galveston-Texas City ND- FORT PIE SAN JUAN-CAGUAS-ARECIBO LAKELAHAVEN - HONOLULU Brazoria HOUSTON-GALVESTON-BRAZORIA WINTER M BEACH WEST PAL ON AGUADILLA Arecibo San Juan-Bayamón RADENTON BOCA RAT uderdale LAREDO CORPUS CHRISTI SARASOTA-B DA Fort La PUNTA GOR I- AL MIAM LAUDERDALE PONCE ERS -CAPE COR FO RT FORT MY NAPLES MAYAGÜEZ Miami Caguas McALLEN- 0 100 200 300 Kilometers EDINBURG-MISSION 0 20 40 Kilometers 0 100 200 Miles Metropolitan Area boundaries and names are those defined by the 0 20 40 Miles 1:15,000,000 Federal Office of Management and Budget on June 30, 1999. All BROWNSVILLE- 1:5,000,000 HARLINGEN-SAN BENITO other boundaries and names are as of June 30, 1999. U.S. DEPARTMENT OF COMMERCE, Economics and Statistics Administration, Bureau of the Census 15
  • 24.
  • 25.
  • 26.
    Measures constructed Idea Measure Innovation Patent applications Entrepreneurship Establishment births, 0-19 VC Activity Investment count R&D Funding All federal funding 17
  • 27.
    Identification procedure Innovation/ VC Activity LP Returns E’ship ??? 18
  • 28.
    Identification procedure Innovation/ VC Activity LP Returns E’ship ??? 18
  • 29.
    INVESTECO PRIVATE EQUITY FUND III Limited partners $ Portfolio companies General partners $ 19
  • 30.
    Portfolio Asset Allocation 12% Limited partners 13% 41% 34% Stocks Bonds Cash Alternative 20
  • 31.
    Instrumental Variable: Portfolio Rebalancing ¯ IVit = Rt × Ni Nationwide Count of institutional avg returns investors in region Year FE remove macro-level economic effects Use of industry average return and MSA FE remove regional effects 21
  • 32.
    Population (thousands) 659.4 1104.9 3270 Patents 246.8 583.0 3270 Patent Citations (5yr) 1228.2 3671.0 2614 Births of Establishments, 0-19 1415.2 2523.6 3270 R&D Support (millions) 49.6 122.6 3270 VC Investment Count 15.9 106.4 3270 Innovation VC Investment Amount (millions) 39.8 340.1 3270 Table 2: Effects on Innovation (1) (2) (3) (4) (5) (6) Patents Patents Citations Patents Patents Citations Population (t-1) 1.427∗∗∗ 1.405∗∗∗ 1.721∗∗∗ 1.453∗∗∗ 1.444∗∗∗ 1.719∗∗∗ (4.81) (4.71) (3.45) (4.90) (4.87) (3.46) R&D Support (t-1) -0.000460 0.0202∗∗ 0.0207∗∗ -0.000410 0.00720 0.0145∗∗ (-0.19) (2.19) (2.00) (-0.17) (1.53) (2.00) VC Count (t) 0.0231∗ 0.0261∗∗ -0.00568 (1.83) (2.05) (-0.37) VC Count (t) x R&D (t-1) 0.00764∗∗ 0.00636∗ (2.27) (1.78) VC Amount (t) 0.000643 0.00143 0.000229 (0.42) (0.89) (0.11) VC Amount (t) x R&D (t-1) 0.000452∗ 0.000654∗ (1.71) (1.73) Time period 1993-2002 1993-2002 1993-2000 1993-2002 1993-2002 1993-2000 Year Dummies Yes Yes Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes Yes Yes 2 R 0.16 0.16 0.15 0.15 0.15 0.15 Clusters 328 328 328 328 328 328 Observations 3270 3270 2624 3270 3270 2624 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. 37 22
  • 33.
    Entrepreneurship Table 3: Effects on Entrepreneurship (7) (8) (9) (10) Births Births Births Births Population (t-1) 0.820∗∗∗ 0.815∗∗∗ 0.825∗∗∗ 0.821∗∗∗ (10.43) (10.25) (10.55) (10.45) R&D Support (t-1) -0.000679 0.00413 -0.000658 0.00319 (-1.04) (1.54) (-1.01) (1.34) VC Count (t) 0.0100∗∗∗ 0.0107∗∗∗ (2.97) (3.12) VC Count (t) x R&D (t-1) 0.00178∗ (1.89) VC Amount (t) 0.00101∗∗ 0.00141∗∗∗ (2.57) (3.21) VC Amount (t) x R&D (t-1) 0.000229∗ (1.73) Year Dummies Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes 2 R 0.22 0.22 0.22 0.22 Clusters 328 328 328 328 Observations 3270 3270 3270 3270 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. 23
  • 34.
    Robustness Table 4: Robustness to Removing San Francisco Bay Area and Boston Excluding Bay Area Excluding Boston (11) (12) (13) (14) Patents Births Patents Births Population (t-1) 1.421∗∗∗ 0.813∗∗∗ 1.409∗∗∗ 0.816∗∗∗ (4.75) (10.22) (4.72) (10.27) R&D Support (t-1) 0.0138 0.00398 0.0194∗∗ 0.00388 (1.60) (1.45) (2.10) (1.43) VC Count (t) 0.0190 0.0101∗∗∗ 0.0254∗∗ 0.0104∗∗∗ (1.56) (2.89) (1.99) (3.05) VC Count (t) x R&D (t-1) 0.00529∗ 0.00173∗ 0.00736∗∗ 0.00169∗ (1.68) (1.79) (2.17) (1.77) Year Dummies Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes R2 0.15 0.22 0.16 0.22 Clusters 324 324 327 327 Observations 3230 3230 3260 3260 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. Table 5: Innovation by Agencies Source of R&D Support HHS NSF DoD DoA NASA 24 (15) (16) (17) (18) (19) Patents Patents Patents Patents Patents
  • 35.
    VC Count (t)x R&D (t-1) 0.00529 0.00173 0.00736 0.00169 (1.68) (1.79) (2.17) (1.77) Year Dummies Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes R2 0.15 0.22 0.16 0.22 Innovation by Agency Clusters Observations 324 3230 324 3230 327 3260 327 3260 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. Table 5: Innovation by Agencies Source of R&D Support HHS NSF DoD DoA NASA (15) (16) (17) (18) (19) Patents Patents Patents Patents Patents Population (t-1) 1.411∗∗∗ 1.403∗∗∗ 1.397∗∗∗ 1.441∗∗∗ 1.425∗∗∗ (4.77) (4.71) (4.71) (4.85) (4.77) R&D Support (t-1) 0.00997 0.0135∗∗ 0.0119∗∗ -0.00108 0.00888∗ (1.57) (2.30) (2.25) (-0.52) (1.85) VC Count (t) 0.0272∗∗ 0.0267∗∗ 0.0308∗∗ 0.0250∗ 0.0258∗ (2.09) (2.08) (2.28) (1.75) (1.94) VC Count (t) x R&D (t-1) 0.00245 0.00543∗∗ 0.00348∗ 0.000502 0.00142 (1.09) (2.41) (1.82) (0.51) (0.74) Year Dummies Yes Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes Yes R2 0.16 0.16 0.16 0.16 0.16 Clusters 328 328 328 328 328 Observations 3270 3270 3270 3270 3270 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. 39 25
  • 36.
    Entrepreneurship by Agency Table 6: Entrepreneurship by Agencies Source of R&D Support HHS NSF DoD DoA NASA (20) (21) (22) (23) (24) Births Births Births Births Births Population (t-1) 0.817∗∗∗ 0.812∗∗∗ 0.814∗∗∗ 0.822∗∗∗ 0.820∗∗∗ (10.33) (10.23) (10.32) (10.34) (10.41) R&D Support (t-1) 0.00146 0.00426∗∗∗ 0.00211 0.000191 -0.000157 (1.07) (2.76) (1.42) (0.31) (-0.10) VC Count (t) 0.0104∗∗∗ 0.0111∗∗∗ 0.0113∗∗∗ 0.0113∗∗∗ 0.00967∗∗∗ (2.94) (3.23) (3.07) (3.11) (2.67) VC Count (t) x R&D (t-1) 0.000295 0.00161∗∗∗ 0.000614 0.000312 -0.000138 (0.64) (2.77) (1.19) (1.24) (-0.25) Year Dummies Yes Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes Yes R2 0.22 0.22 0.22 0.22 0.22 Clusters 328 328 328 328 328 Observations 3270 3270 3270 3270 3270 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. 26
  • 37.
    Table 7: LagStructure of R&D Effects on Innovation (25) (26) (27) (28) (29) (30) Patents Patents Patents Patents Patents Patents Population (t-1) 1.418∗∗∗ 1.405∗∗∗ 1.405∗∗∗ 1.398∗∗∗ 1.415∗∗∗ 1.418∗∗∗ (4.77) (4.71) (4.71) (4.71) (4.77) (4.75) VC Count (t) 0.0239∗ 0.0261∗∗ 0.0263∗∗ 0.0270∗∗ 0.0261∗∗ 0.0253∗∗ (1.88) (2.05) (2.06) (2.11) (2.05) (2.00) R&D Support (t) 0.00803 (0.85) VC Count (t) x R&D (t) 0.00246 (0.71) R&D Support (t-1) 0.0202∗∗ (2.19) VC Count (t) x R&D (t-1) 0.00764∗∗ (2.27) R&D Support (t-2) 0.0190∗∗ (2.23) VC Count (t) x R&D (t-2) 0.00689∗∗ (2.20) R&D Support (t-3) 0.0221∗∗ (2.41) VC Count (t) x R&D (t-3) 0.00809∗∗ (2.38) R&D Support (t-4) 0.0174∗ (1.81) VC Count (t) x R&D (t-4) 0.00733∗∗ (2.11) R&D Support (t-5) 0.0157 (1.60) VC Count (t) x R&D (t-5) 0.00761∗∗ (2.13) Year Dummies Yes Yes Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes Yes Yes R2 0.16 0.16 0.16 0.16 0.16 0.16 Clusters 328 328 328 328 328 328 Observations 3270 3270 3270 3270 3270 3270 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. 41 27
  • 38.
    Table 8: LagStructure of R&D Effects on Entrepreneurship (31) (32) (33) (34) (35) (36) Births Births Births Births Births Births Population (t-1) 0.821∗∗∗ 0.815∗∗∗ 0.815∗∗∗ 0.813∗∗∗ 0.811∗∗∗ 0.812∗∗∗ (10.49) (10.25) (10.23) (10.18) (10.11) (10.15) VC Count (t) 0.0101∗∗∗ 0.0107∗∗∗ 0.0105∗∗∗ 0.0107∗∗∗ 0.0108∗∗∗ 0.0107∗∗∗ (2.97) (3.12) (3.07) (3.12) (3.15) (3.13) R&D Support (t) -0.000782 (-0.34) VC Count (t) x R&D (t) 0.000329 (0.40) R&D Support (t-1) 0.00413 (1.54) VC Count (t) x R&D (t-1) 0.00178∗ (1.89) R&D Support (t-2) 0.00382∗ (1.67) VC Count (t) x R&D (t-2) 0.00128 (1.56) R&D Support (t-3) 0.00444∗ (1.81) VC Count (t) x R&D (t-3) 0.00154∗ (1.78) R&D Support (t-4) 0.00588∗∗ (2.20) VC Count (t) x R&D (t-4) 0.00188∗ (1.95) R&D Support (t-5) 0.00602∗ (1.94) VC Count (t) x R&D (t-5) 0.00193∗ (1.74) Year Dummies Yes Yes Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes Yes Yes R2 0.22 0.22 0.22 0.22 0.22 0.22 Clusters 328 328 328 328 328 328 Observations 3270 3270 3270 3270 3270 3270 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. 42 28
  • 39.
    Table 9: LagStructure of Venture Capital Effects on Innovation and Entrepreneurship (37) (38) (39) (40) (41) (42) Patents Patents Patents Births Births Births Population (t-1) 1.405∗∗∗ 1.414∗∗∗ 1.420∗∗∗ 0.815∗∗∗ 0.815∗∗∗ 0.818∗∗∗ (4.71) (4.73) (4.77) (10.25) (10.15) (10.17) R&D Support (t-1) 0.0202∗∗ 0.00413 (2.19) (1.54) VC Count (t) 0.0261∗∗ 0.0107∗∗∗ (2.05) (3.12) VC Count (t) x R&D (t-1) 0.00764∗∗ 0.00178∗ (2.27) (1.89) R&D Support (t-2) 0.0247∗∗∗ 0.00177 (2.80) (0.49) VC Count (t-1) 0.0195 0.0108∗∗∗ (1.60) (2.59) VC Count (t-1) x R&D (t-2) 0.00894∗∗∗ 0.000520 (2.83) (0.40) R&D Support (t-3) 0.0298∗∗∗ 0.00239 (3.67) (0.70) VC Count (t-2) 0.0145 0.00837∗ (1.22) (1.92) VC Count (t-2) x R&D (t-3) 0.0109∗∗∗ 0.000782 (3.73) (0.63) Year Dummies Yes Yes Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes Yes Yes R2 0.16 0.16 0.16 0.22 0.22 0.22 Clusters 328 328 328 328 328 328 Observations 3270 3270 3270 3270 3270 3270 Notes: OLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Robust t-statistics in parentheses; disturbances clustered by MSA. 29
  • 40.
    Instrumental Variables Table 10: Instrumental Variables Estimation for Innovation and Entrepreneurship (43) (44) (45) (46) 1st Stage Patents Patents Births Births Population (t-1) 1.116∗∗ 1.330∗∗∗ 1.368∗∗∗ 0.803∗∗∗ 0.813∗∗∗ (2.45) (4.71) (4.85) (9.32) (9.13) LP Returns 0.0112∗∗∗ (10.49) R&D Support (t-1) 0.000791 -0.000617 0.0265∗ -0.000706 0.00664 (0.60) (-0.22) (1.89) (-0.98) (1.60) VC Count (t) 0.0957∗∗∗ 0.0814∗∗ 0.0227∗∗ 0.0189∗ (3.23) (2.57) (2.35) (1.95) VC Count (t) x R&D (t-1) 0.00974∗∗ 0.00264∗ (1.98) (1.83) Year Dummies Yes Yes Yes Yes Yes MSA Fixed Effects Yes Yes Yes Yes Yes R2 0.27 Clusters 328 328 328 328 328 Observations 3270 3270 3270 3270 3270 Notes: 2SLS regression results; * p < 0.10, ** p < 0.05, *** p < 0.01. Bootstrapped t-statistics in parentheses. 30
  • 41.
    Venture capital ascatalyst to commercialization Increased innovation Increased entrepreneurship 31
  • 42.
    Further results Non-compete covenants Social capital 32
  • 43.
    End note: Key togetting funding 33
  • 44.
    End note: Key togetting funding 33
  • 45.
    End note: Key togetting funding 33
  • 46.
    End note: Key togetting funding Applied Physics Research 33
  • 47.