This contains information and resources for the PGS-PRS workshop at the NSHG conference in Estonia https://nshg-pm2023.org/

The workshop will be led by: John R Shorter, Roskilde University, Denmark https://forskning.ruc.dk/en/persons/johnsh

The presentation for the workshop is titled: NSHG2023_workshop.pptx

The first session is using the PGS catalog

Here is the link for the PGS Catalog https://www.pgscatalog.org

Here is the link for the PGS Catalog exercise https://docs.google.com/spreadsheets/d/12Dg6DaHDzG0SqrQz3HNeK51IVAR23HcRY3Q2jul953o/edit#gid=0

For the second half of the workshop, we will work through the LDpred2 tutorial, by Florian Privé https://privefl.github.io/bigsnpr/articles/LDpred2.html

The R markdown document we will work through is: LDPred2_workshop.Rmd Also included is an .html version of the R markdown file

Three additional papers are attached for more background reading on these tools. They are included in this directory.

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

Tutorial - a guide to performing polygenic risk score analyses

LDpred2 - better, faster, stronger