Drug Actions Indications Adverse Effects Contraindications Nursing Responsibilities

Generic Name - Acts directly on - Hypertension CNS : Headache, Concentration Before

Hydralazine vascular smooth muscle - Eclampsia peripheral neuritis, - hypersensitivity - Check BP
to cause vasodilation, dizziness, tremors, - CAD Arrange for CBC, LE
Trade Name primarily arteriolar, psychotic reactions - mitral valvular cell preparations and
Apresoline, Novo- decreasing preipheral characterized by rheumatic heart disease ANA titers before
Hylazin resistance. depression, therapy.
- maintains or incrreases disorientation, anxiety Precautions - Assess for
Minimum Dosage renal and cerebral flow - with CAV’s contraindicated
5mg/hr by IV infusion CV : Palpitations, - increased ICP conditions.
tachycardia, angina - severe hypertension - Observe the 15 rights
Maximum Dosage pectoris, hypotension, with uremia of drug administration.
10 mg by IV Infusion paradoxical pressor - advanced renal damage - Assess bowel sounds.
response, orthostatic - slow acetylators - Assess voiding pattern.
Contents hypotension - lactation During
Hydralazine HCI - pegnancy - Give oral drug with
GI: Anorexia, nausea, - pulmonary food.
Pharmacologic Class vomiting, diarrhea, hypertension - Use parenteral drug
Vasodilator constipation, paralytic immediately after
ileus Drug Interaction opening ampule.
Therapeutic Class Drug to drug - Instruct to take drug
Antihypertensive GU: Difficult - increased exactly as prescribed.
micturition, impotence pharmacologic effects of After
Routes of beta-adrenergic blockers - Withdraw drug
Administration Hematologic: Blood and hydralazine when gradually.
Oral Dyscrasias given concominantly - Discontinue if blood
Intramuscular dyscrasias accur.
Intravenous Hypersensitivity: Rash, Drug to Food - Arrange for pyridoxine
urticaria, pruritus, fever, - increased therapy if pt develops
Availability chills, arthralgia, bioavailability of oral symptoms of peripheral
> Tablets - 10,25,50,100 eosinophilia, rarely, hydralazine given with neuritis.
mg hepatitis, obstructive food. - Monitor for orthostatic
>Injection - 20mg/ml jaundice hypotension.
- Report persistent or
Other: Nasal severe constipation,
congestion, flushing, unexplained fever or
edema, muscle malaise, muscle or joint
cramps,splenomegaly, aching, chest pain, rash,
dyspnea, lupus-like numbness, tingling.
syndrome, possible - Do proper
carcinogenesis, documentation
lacrimation,
conjunctivitis