INFORMAL

PATHOLOGY
NOTES
•

•
 INSTRUCTIONS

•
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 INDEX
GENERAL PATHOLOGY
TOPIC PAGE NO.
1. Cell Injury 5
2. Immunopathology 16
3. Hemostasis and Hemodynamic disorders 27
4. Transfusion reactions and CML 41
5. Necrosis 45
6. Inflammation and Repair 47
7. Anemia 57
8. Neoplasia 61
 SYSTEMIC PATHOLOGY
TOPIC PAGE NO.
1. Blood Vessels 75
2. Heart 80
3. Respiratory System 91
4. GIT 111
5. Liver 130
6. Kidney 147
7. Endocrine System 163
8. Male Genital System (MGS) 179
9. Female Genital System (FGS) 185
10. Skin 192
11. Breast 198
12. CNS 206
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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alsssmnte
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Page

SLE
Systemic autoimmune | collaqen lisase
Tuoo ovms

OSysiemic) Dissemi natad Acuk a chwnic intlammatorn

egions, Satd, ntekeascuteplagaie Feer-bsetio3.
FDiscoid Chronic locabized

CHoloy
Factos:
GeneHc
mmunoequtab ole Class 9) HLA gen
EniDn
Envionmental 9Dauas CPiniallamine D)
i) vira iotecHom ceBV)
Hormone oesrogen)

Pathogenets
AutcantHbod ies against nuclea & toplagmlc Lomponerts-
ANA Aninuclear AnHbdu AnHbodies ayns DNA
RNA In 98y. cases
Amtibodies
ho double shranded DNA5
AnH-ds DNA mast specitc
e3peally in niah Htteg toy, caleg.
Anti-Smit anHbody > nH-Sm Against Smidh anHgen n
onucleopooheing
Non Specihc antibodies Ati-ibonucleopoteins (Arh-eNP),
Ani- phospholipid antiboclie3 (APLA) tupus anHcoaglapt),
AnH-nishtne antibod

AnH'bodu souce 8 Hypergamma globuioemia blyclona

B cell activatto Oinhei ted deteet
B celstimuuaHon
Helper T cel\ nperactHv
(4) Supot 25 0 T ce}\ dekecl
 Pushti Devi
Deven Bhusari
clAsSMALte
LTMMC, MUMBAI Date
Page

AubantHbodies againgt
Tissue injury0Type Hypesenstt*Ih| > Hamaholoqical blUop
derangenents

Tpe 1 HypersensitHvi >Ao-Ab complex depottHon Igornen1/ BV

LE cell Phencmenon
diaanosHc tesF
penehsate Inat aell3 & Duder shsuld
Pineiple » ANA can not
be exposed kos ANA dinding.
nucleas chomatin * ANA Homogenou mal&
E body
CHaemabxylin body)
conjch
eucocye CPMN, monocyte ) engu
L e ce}l Phagocyic
ouclear matet'a) nlucleus O ce
nomogenous
cdlisplaced tD Neutophl)

Iintact ymphocyes phagoe tosed by a

Tat cel >mass
Monout it ls tast cel

Motphologtcal feahures 8-
E hematoug CteuneTUS
exupion8
Poincfple lesions >TENad, vascu la), udan eaus, candiae.
CN3
04hery osgans tHissues- serosal ining, spleen, liver ,

Histology fibrinnd necosS in ejons. in CT endo theliu

Clinica ae3-
MOTe Commm in omen (20 30yn
MuHsyskm disease.
Taget og ans>Musculoseeletal sisem, Skin, kidney, t s ,
heontt,blood e3sels, G1T

raHgue, myaugia ever ot los

Buttexy asta on oose& cheek
Pushti Devi
Deven Bhusari
LTMMC, MUMBAI
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Deven Bhusari
LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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Deven Bhusari
LTMMC, MUMBAI
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Text
Pushti Devi
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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 NEOPLAS TA Pushti Devi
Deven Bhusari Date
LTMMC, MUMBAIPage
STUDY BUDDIES
FEATTU RRE
BENIGN MAUGN AT
)AN
PPLAS(
a)fleomophic

N c rtho

hypeacho mah' e
)Abmitose

)GcWTH
3o gowi eopict
aMetStTURiS

tnuasto) e

Capsule wel-encapsulotec DecepHve encapsuarel,

4

Progesis. abed Bad

Fbeat om siqnt haurm f icand haum

d/t invasio) or
dlt Jocohom
Complicanor mets

Pain fou nw Pclnless

)&hape aPoulan
b) me oth Necula
tela
 Pushti Devi
Deven Bhusari
oP CANCER LTMMC, MUMBAI
AB DIANOSIS

Rtd. method Histologiccu Eamy

&old BEST

e Bx tissue,

Methodl& ) Hishofe9taoy
utrolegico
aHistochemf
A) tmmune wishothewmlsth
) EM
MPE) TUMOR MARKERS
PloLo Cto mety

-HISTo LOGICAL
baged om mi cos Lopic exam at tained
tumo cels,

stuolied
stuolid wnde o elechon Us cepe,

t ee Retesul
eTd
LO GCAL
Rtuoty ak tumor cel
a)Ex toRiahive cdo
shreddecd aht in bodu aul
Spurum (cse examumorfumor cell,

PUAC -d hhe Needle. spisa tol olgy

humcy h'ssue is aspirated by gine
needle3 cells a2e tudiec
in Ca Ce2ux,
f a p foLp 2toin
 Pushti Devi
Deven Bhusari
HtgToCHEMICTR- LTMMC, MUMBAI

ehem, ompo siho ex U g huoied

e Dsis at concen.
T u n OC celts coreio iNTEemEDI eT
MoNO HISTD CHEMISTDy Gers CU heIT n.
Immunolegicou method is tseo in Asis a Concen

TUMO MARKERS - CBiochem ossa)

ubstunces prodused by humai Cou
in bloed other body tleuds
NOTE:) N) cell& aulsopodLce Oaeken
heae &ubstan Ces
w rudcs ed olonq T patheleqica) Osit.

Ase PanosiS 3therapehc pupose

They ncude -

suehace gs-
)Ca Uen

Eo 2unmeg fi D Co Prostadthe
) New2oolaRtomag

Homon el Co mo td
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI Date
fage

6PLOw cTomeTR
Pos tquuld tumors

BTcels Jurnphomou
euukeriog

URCULATINGTUMOR CELLS:
MetaRtahc ce sound in
can be bod
Huids Some eulce
w )Encuble
Ecuey Dets
) Lse8 sk ak Meg

pofarkor
 Date
Page
STUDY BUDDIES
Pushti Devi
Deven Bhusari
LTMMC, MUMBAI
CHEM CAL CARCINO GENESIS -

OLLUROd ollt
Con ceous (os transtomatn
Exposne to o hemicol

(wthtouh
- 2 Promo)

to chemicouls Aong o
INITI AToN Eposune
nn dluraim,
PerManent
an in oueecl ane
eh gS
&uoloe
1reuensi ble,

concinege
oups OPinCof achng aart
Alkylauh'n alahng aewh

InolirecH achn PROCARCINOGENS

Metabolic_
Chenucalg CARCINOGEN
eonvegio)

Can cinogen DN coe

DNA Muu

Mutahed D it u n d e 0 ccle o
polierah hen
beome Peamanet meuensible
Damase
Damae
 S RDIES
Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

P RPROMOTION
o

PomofemS Ce DPhenols

n) Hormon e
3)Atbcia Sweetmes.

PROGRESSION

Reuu a pYotierau o mtateo celk

phenohpicaly um cella

TUmoK

34
 STUDY BUDDIES
Pushti Devi
Deven Bhusari
METASTRSIS LTMMC, MUMBAI

d
c tumoy oy JVOSION rom 1 s1he
othen RieR or an

han uhune ab MALIGNANCY,

PLL umors meteRtouRi

except D Gtomas o CNS

O BCC cly skin

Benig umorS mets

Ropidua asDotnq mets c).

a ROUES

Direct seeclin Tsans coelomc

umphahcs 2 Hemadeqenou
o bed 2Cmuckenbe
mc ouheer mc DUhee aaulhe umor

Cors cinomay SarcomoLs ( t omoch- d tan

LYmPH ATC 3PREAD; ovolument

a n be bu

Permeah- ca ceula idvede tuetlls

umphdhe
mphaics s tom conhinuD oo
D h
o Hh.
a

mphahc emboli -
Tumoy celk detech F for
e
TOMOR EMBOLI Aho ane camad to nex &

oaii
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

)Tutnc ceuR enhe N

3ub-capsuloun

ume ceUg ouowe PeCONAL UN

4Ceeneraul
Axlony
)Ca
Hi(cu LNS.
O) Co Bonchuug

w8P METS 3omekme mphahc me onot

invole rs N 9poce fro oli stant ty
naetDmogei,
t) veno- ymphadtic

METS Tum o eUs

PETROGe ADE
olU'ne ch'o) a m ph tlow
tv aupra-laui cada2 (
R0 Ca Prostahe

2T99
HEM ATD &tNooS SPeEAD 3pneod ulonq bloed
rhoogmud

(mo Sancomas Spead

Some Carcinomcd pmeacung by meb
oute ) Co Beast.
hem atogeh ouu
2)Co Tyroid.)

Commen shesat Met e ung

. e3 econdania

) Bone.
4) r

spleeh uuallly not involed

2 teett tmuus cle
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI
etemfe vetns
eck, Pecce Jmbs pelytg
oTcun into Juun
Ted mes to Cungs sites
uungs ro thee

) fobeul veln- Bowel 9plean, Pan cmeous

Ased mets to Cven rom hic organs

e a i a l spread -olibicult ro intod

d I tuickea ocull,T t

Ketoarade gpead 61 venotug ccleu8to)

Ca
Ca Prostote Nerrebra Column
-93 trioonp-
GrosS- Mohemaheq enouegpreoo

Muulhple ound 1 acotteeol, nccluley

eul coven the erq
2capro

ecopy Metastuhic 1estop eemses tum cY.

efi

3PPEAD ALONG BODY CAVITES NATURAL PAsseGrES

CTPANSCOEOM( tumor celle bmedk ot6 and

one Cauied in coelomic uid
to other sihe

tomach * OvaeH
eq
Crrucker bengis tumor
 Pushti Devi
Deven Bhusari Date
LTMMC, MUMBAIPagye
STUDY BUDDIES
Spreod
( ) enq epitheUe 9untace
o Bonchug HUeoli

Gi) [Link] 4hrtugh cf

Meningeal tumorS

Mechawicy MetaRtaRis Pq66

) Detachmen at turno cetls Loss a E-Codhei
) tach to eCM Dteqnins
LOmiuln, Pibonechn
ECM
degraolat MMP-29
BM bredkdown Tupe-1V collaaehaRe

4 a o En nto Bvis

s2peod to di b r9an
TumoY
cellg
Ploteleks TUMOK OTansS
EMBOL) Venul

Lyph Node,
n0)39) 2 r
 Pushti Devi
PNS Deven Bhusari
LTMMC, MUMBAI

De
Dekh mp conpe xes geen in Concen pts ohich
a unDot be
explained Locad 2PREPO 0P TbMOR

w 9i Preduanced concens

Co uun Co ACACH

CLAgAinI nd
Onno e e p ained y ste
e in lunq ouso
&paod a tumncy

undaDme Tumo &ubst produced

C unq &DH

Cugingis c ung ACTH

gcC- m a l RU Ca
HYPER CALCEM1A )8Cc-lung PTHf
. Co Breash
2) Preot

Hypogly eermfo DOvofan Co

2) pfbogarComo 1Gf

Polucuthemia RCCCidney Enythropoeih

alooedt ECTDPIC HORMDNE PRODDn ON

A
 Pushti Devi Date
Deven Bhusari
LTMMC, MUMBAI
fage
STUDY BUDOIES
Syndro me
Tumg &ubst Produed
Miqajatom DCo Colop
Thpmbophebih
CO Pancme au

)Aconthosic

)Co Colo) EGF Epiclenmau)

igiconS Co tomach

8Mydgthenia ) Thymoma

Co Lunq
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Deven Bhusari
LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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LTMMC, MUMBAI
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Deven Bhusari
LTMMC, MUMBAI

Date:

ME NDROME

Def Multple EdocaineNeoplasfa- Multiple denomas)4hypeaplasias

of diffclent endoctine otpns PAoducinqheleogenous dintcal
codwnes
Pmo yoid
MEN- Syndao me
AkA Weames Sundhome. ePs foncreo heTee
Adenomas 0 [Link] panceate slek phtuiMa
Prutcsomel dominant
MEN menin gene
2anactnyaaid- Hupeaplasa oadenoma
-anaeat isle-Hypeaplasla or
hypeapaiathyADidism
adenomd
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LTMMC, MUMBAI

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LTMMC, MUMBAI

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LTMMC, MUMBAI

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LTMMC, MUMBAI
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LTMMC, MUMBAI
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Deven Bhusari
LTMMC, MUMBAI

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LTMMC, MUMBAI

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LTMMC, MUMBAI

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LTMMC, MUMBAI

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LTMMC, MUMBAI
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Deven Bhusari
LTMMC, MUMBAI

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Deven Bhusari
LTMMC, MUMBAI

Date:
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CELL CARCJNOMASpindde Ceca

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Deven Bhusari
LTMMC, MUMBAI
Nuean hypen chrom aism
Mitohc b'gne Date:
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 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

Date:

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 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

Date:
MAU CCN ANT MeLANOMA

Def [Link] 19 o dumoaisingom melanocte

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DAa 05 shghtiy elevated nqevus

[Link] Plamentaon irvtqula boAdel

Seconday Changes ulcetahbn, blecding ttin sioe.

 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI
Date:

Assummettical
Botde inegulauh
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LTMMC, MUMBAI

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MaukelAunchiona acHyitu a epldeimo-dletmal unchian.
Inlra
CrsbuDs Inuooids nto deamis
nti
2-Tumor uellsy
age han naeN ug cells.
epitheloid 0 O Spindle shapec
AmphophituUc Lutoplas nm oith peomonphic nudel corspidoug
nudeol1
Mitotic ARouuea mulkinudeatd cela
Pattean.& Solid mases sheek land alvecli e

Melanin g-
Paesent melanefe melado na) Atbse Lonelanotic [Link])
UnifoAm fine qaanulea ) HMB 5
Stain-fontona Mass on
a) s10o
HC moukela HMB 45 S-100, Melan A. maeke
)Melan- A

-IntHammatDiy infitak seen upeet efo

fapille pEEp Jauyen at den
dezmfsS
)beneath epideamk
Leuels els o melanoma:
) tuo8Culan
levels.
Leve)-1:- CDnfineo to eptdeAmis & iappendoge
Level11:Exdends to papiUouy deamlg
leve-n1- Uplo interfoce beBueen papilaiy ehiula deinmi3-
level IV- Invasion to chcular demis
Subtutaneous tut
Level V: Invasion Page!
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

| ABROADENOMA

wwDef Benign tumo of Pibvous &epithelial elements

AKAAdenofibADma

Age-S- 30 y
CAinica featuues
eely mobile noduue>Benin Benign
Solitay discete ehon

w Morphological tatueS
C GDss
wel)
wel) encapsulated .spheical on discoid
small,solitaiy,
mass
Cu 9ulface- Firm,
ey whitt, sightymyxDid.
)SNE ike spaces foamed oy omphexsed
duc fibAoadenomas - fibrcystic disease- fbroadenomatosis
Mutiple
ibroadenomq, lage in ei2e Giant oroadenama

MicTOSCopy
(A)-nta canatituuaa pattein
StEoma ComprsseS theducs educed to slH uke clofts

uinee by ductodepitheium
Ma
May aPpe as CDds o epithelial elemerts

(E-fericanaliceua patein .
Encivclinq masse of HibYOus stoma aound paeDtd
dlated ducts
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

Date:

MoapholbgicalvOias
-Tubula adenoma-Scanty fibAOus issue losely packed
tubula or adina pAbat?prtdominant

Lactadinq adeneomat Hcini onh secetoAy ativity

Suvenile4ibpadunoma in
lage sapldly rooing maasIn
adolescerd gials
X
PHHLLODEs TUMOR

Dep Untommo loulky bAeakt durmoA uDith lenGkegsossS

appeaance &- 0hetaiveclinical beharisu.

hge-30 t j0ya

Mozphologicau tatues

OGross suekone)
geLOund do ova bosselktd noou eted
e3Shully encapsulaked
u surtare eywhi 2qeic Cavies,eas
Mattyt haermonhge, nech0sis 4 elegenoiakivt changes
eibrug +scueg
MicosLopy
Exhemey hypeicelUulo Aoma
Benign ducal etuctues.
.Mautke d stoma) ovegaoeth
tequent mitoses, eltulaa ahypla
Hiah celluauiy,infi Htottve magins
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

GREASTTUMORS

OBenigo Malignaunt
PTDodunonna
Phyllodes tumot Non invosive nvasive Faget's
Initadlucta papillomaacinama cioma Dsease q
Fhitaductal ta DIDAtating Nipple
lpbuway (a in sitsduct ca D)
)InHating
lobula Ca
NIC Tubulan a
I n a - DUcL a
)Meduloya
Coloid Ca
2LOBULPE -CS OtneAs

BREAST CARCINOMA

Risk facton

OCteoqaphic Racial factoas-

t to 6 imes ighe sk in developed (Duntiea
pw aisk m developinq ounfies.
Hispanic&
&ican- Ametian wemen taly oge
odvanced Gage

Family History
fist deayee elaive o patent-Qto 6 times 1 isk
Risk No oblood clattes T orast Co
Mounqe age
dgildool Ca
Aigh isk a famit
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

Date

s 3 Menstual obstetic histou

D Total length menstcual fe A
tisk
Risk7ealy menaiche
nuttipauity Wornan coho hag neuer qiven BRTH.

lat age oist childbizth

delaued menofuse

fibAocustic change
-.whenassociattd aotypical, epithelial hpexplasia- S told Myisk
CMiscellaneous AoadoA
LonsumphHon o animai ars, hah calotiediet
Smokinq
Alcohol
8neas augmetaHon sugery
High btaut densi 'hy
EAposAe to adiation.

S dtristwkgo Invasive Infi HtaHing duc

S Not otheoise
ocinoma:-DC
speciHed ype lassic brtast once.
Most ommon histologt paitein
Chnica feadtuues
Havud consistenCy due o dense collagenaus stoma
Mostly seen in
\Csxirshous (a)
1etrtast on uPpel_oule quadaunt-
BRekacHon onigple å attachmert ot tumor to
ipee goeR hoands chest oall
Motphola gical Aeatuues
aDss
krequku haud Cantilage uke mass
PAoduce 9taBing sound on
uthna
Cu Sutface -*gseyish ahit to tjella, chalky steas
CAtends M1eeulozly n suletud fat
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

upical
Micaoscopy
lackogudat
quat& unifotm patten
Anaplo cels- soid nests, cends, pcoaly tbxmed
lan dulasuctoses some arnhadetad foc
Inettaton o cells into diptuse fiblous stoma at-
bmedone
peavasuda& peainetua 9paces
radinq
Alaeds SCOAing sysHem
for ER &Pe
opo Hon scoAe ( ocells showling posiHviny)
O No cells tve
417<1 cells tve
2- to ld . tve
3 1to 37. tve
34 to 67 "% tve
S 61 4o 100 7. tve).
Intensih sbie ( intensinyn dshaining)
D Neaatiye
Mild
2
3
Modeiat
Sevele 1 Giong
ANed SONe Paoposton SLOxe
+Inhensihy sCONe

HC for Her/ne
Hex 2 Ineu negaive
2-FISH Aest Pluorescent lo-Situ Hybridisatn
3 He2 Ineu tve
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

Ctint cd shoging

Stage Desaiptiom
1SCa wh
Stage19 In gitu Coldnomo

Stage Tumor Cm
No nodal SpAegC

Stage TumoY22cm &<scm

Realonalumph nodea involed
Shage 1WA Tumor Scm
Ragionollymph Dodea involved

Tumor Scm
Supvadavicaula & infiadaviculaa lumph
hodes involved.

Stage N Tumor any si2e

uth oY othaut tgional sprtad but) uoith
distant metastasis
 Pushti Devi
Deven Bhusari Date:
LTMMC, MUMBAI

Prognosticfactons-
FACTOR &OOD PRO&NOSIS BAD PRo&NOSLS
ORoutine (ecoe)
Histopadhology
aiteia TM
aHistologic Special tupes ( Medulloy Ca, DC CInfI Mative duct
upe ubulo Co, mucinsus a ett) aninoma)

Tumer si2e lem lem

istolbgicqracim- Louo qrade qade High grade lqroded l-

based on deqee SLone -S Stoxe 8t9
tubule tpmat' Modeat grade 1gaade I1-
C1-3), Tequloihy S0e 6-1
Onudei C1-3) tubules ( 1
nikosis (1to Nu clei (133)
M-MitR)(-3)
Axi Ulolynodal Nlodeve Node tve
sHaduu NOR of 0odes 2 No. Df nodes4
Sentinel nodeve Gentine) node tye

Lmpnate Ve 4ve
vasculainvaain

OHtheu
umor cirCumsaptioy Gtood
9kin Involemem Absent Aesent
DHomone ecepy
stads
tVe
ER- PR Ve
2hey neu UnclerepreBsion OveleapAE3S1On
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

D ato

GOOP PROGNOSIS BAD PR O&NOSIS

FACTOR
biologicn
Indicatoh.8 Highm i t o H c o u n t
Mitotic Low mitoHc count
inde (ki-6
S Agiogenesis too Angloqen esi High
Cncegenic
tncogenic
PiSTegda
disAegulaton
BECA 18RCA2 4ve
ve -ve
ve
t
B2
Tynda e cse cAain oals' 2 "d
Date:
i Ahe a h s Aettachecd.
Pushti Devi
MENI NGlT13 Deven Bhusari
LTMMC, MUMBAI

Acule Puogenic Menidgitis

csF oithin
& the
Def Acue infection
DOpia-alachnaid

the sulbaxachnatd spdte ochoig

Etilopathogeneaiss-

Cousative Agents
E CDli-eopatts z neual tube dettcs
Hintiuen2ae- Intank ChildzenD
Meningitidisadolescent, yotunq adulB & epidomic-
Alespfa
Meningitis
ttepBococcus pneumonge2- exkeme o ae

Rouhe
OBy blsod stttam
By adjacent fod of infechian
lakiogenic
Morphological fcatulea-

Onosst
Pus [Link] in gubalachnate [Link].
CSF usbid 8hankly puaulent
Nericutts Rbrinous DattDg on theiu wall
Puelent matelial Et AnHefcae3 wth ese PHow
Causinapbstucive hudochephalsua-

MicroSopy
NumeLous PMNS in subaachnoid space 8 meningc3
tram Stain ougadve baccia.
 Pushti Devi
Deven Bhusari
Chlotide- IsS -t30 o el LTMMC, MUMBAI

Xanlnochaomia Pole pink eltoo cooua ceritituged sampe

Released oxynb 2to24Ahs b onsek s
Tale pin to yelloo>
Nahed eue sulb atachnatd haamrnaqe
aae
9elleto Ao onange > 12 hs afes suoanodh ngtd harory
al> deaued pocessina. icundiee, 03atenalds, Pafa neplcin Alaesap
Mibicau ntures
O fevea
Sevee headache
oadtosiness
Vomting
Stupoy
Coma
Convulsisn.
8Stiness ok neck on orocud bending
GECSF FINDIN&S IN
BACTeRIAL, VIRAL TUBeRCULous
MeNINGT1S
ePmuRE

PCATURe BACTERIAL MENINGITE VIRAL MENIMGITIS TUBERCULOUS MENINGITIS

ed eye Cloudly 1fhankly Slighty tubid Sllgntytuubin; Aimin

peauoncetubid CDaqulum on anding
(couoeb foramaHon)
SPCSA) Raised Rouised Raised
gHssuLe >180mm HeO 2S0 mm H2O 2300 mm Ha0

Cells S-L0,000 PMNslulo-100 lympnocuyhes lad hoo- 1D00 lumphocues u

ec-o-Scelllu
wC-o-stcellg/UL

oteing Mankedty alsed Mildly raised Raisec

15-45 mg ld H5-4S mgldL
luebseMakedly reduced Normat Reduted
SO-8pmg lcl co-1omgel
Dchexioloqy (asaHive baceig 9ule Mtb seen
6&en

ChCWoide Roused Raised

 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

MeNINGOMA

wDe Atise -ftom cap cell layet of aachnoid mainly In

hont holf hcad

Aqe-aDo 604 F>M

Solitaay Inceosedtequeney in poaHens uath

neuucibromakosia-2.E-2

Benign
uytogenetfe alonoyoality-(Deletion) of chomosome 22-NF
NP-2 gene preRent
wMophological fcaturrs
O Gnoss.
we chreumsciloed solid, spheiicou oy hemisphelical
mass-
m h y ettoched to dua

Ovealying oone hypeaostosts

Ccaut
Cut Susface fim & forOus with foc ot calcticaton
M
F
Micsoscopy
Subrypes8-
O Meningotheliomatous meninqiama -

Resemble nosmalarachnotd cap cells

Solid mass es o polygonal cellg Tpoordy dettned celt
membyBne

Round to oval eenttal nu deus oith abundunt

granulo aytoplosm
Collagends stoma
 Pushti Devi
Deven Bhusari
LTMMC, MUMBAI

Date:

Frous meningioma
Spindle dhaped Amobdashfc Aumo
bundles
Tumox cells fom paallel oy intealacina

ransiHional meninglomat
Combination cells zsyncital Rbroblaic coutS
LOhored paBen
Paammsma lbodiesCalcitcation o cental Cohe o Lobols

Angioblastic meningiamd t
pHemangiodaghic pattetn Tesembles hemangiobla&ioma
[Link] patteln sembles hemangiopeiuhoma

AnaplaaHc malignant meningiOma

RatuuesD anaplaaia
Invades braln &spina coad
exfaneual metastasls to lung

[Link] s AH
SE- Subakachnotd
Appeosance Xanthccoromia

PAcheins Hgh Some oMeninqh-

Sugas too
MiooseopyGhost eeCa