2024 Investor Day Full Distribution VF
2024 Investor Day Full Distribution VF
During these presentations, we will be referring to certain financial measures not prepared in accordance with generally accepted accounting principles, or GAAP, including adjusted EPS, adjusted operating income, adjusted operating
margin, adjusted ROIC, free cash flow, organic revenue growth, core revenue, and core organic revenue growth. The non-GAAP financial measures of Thermo Fisher’s results of operations and cash flows included in these
presentations are not meant to be considered superior to or a substitute for Thermo Fisher’s results of operations prepared in accordance with GAAP. Definitions of these non-GAAP financial measures and, for historical periods, a
reconciliation of the non-GAAP financial measures to the most directly comparable GAAP measures is available in the appendix to these presentations. Thermo Fisher Scientific does not provide GAAP financial measures on a
forward-looking basis because we are unable to predict with reasonable certainty and without unreasonable effort items such as the timing and amount of future restructuring actions and acquisition-related charges as well as gains or
losses from sales of real estate and businesses, the early retirement of debt and the outcome of legal proceedings. The timing and amount of these items are uncertain and could be material to Thermo Fisher Scientific's results
computed in accordance with GAAP. Certain amounts and percentages in these presentations are presented and calculated based on underlying unrounded amounts. As a result, the sum of components may not equal corresponding
totals due to rounding.
Please note that the attached presentations contain financial projections and other forward-looking statements that are specific to the date of the presentations – September 19, 2024 – or the applicable dates
indicated in the presentation – and should not be considered current after such date.
© 2024 Thermo Fisher Scientific Inc. All rights reserved. Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, PPD, Fisher Healthcare, Gibco, Ion Torrent, Olink, AccelerOme, AGT, Alexa
Fluor, Ardia, Ascend, Astral, Athena, Attune, B•R•A•H•M•S, C1qScreen, CTS, CytPix, Dynabeads, DynaDrive, DynaGreen, EasyPep, EliA, Explore, Freelite, Genexus, Greener by design, Helios, HyPerforma, ImmunoCAP,
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TaqPath, Tribrid, Vanquish, ViewRNA, and Xenon are trademarks of Thermo Fisher Scientific and its subsidiaries. Tandem Mass Tag and TMT are trademarks of Electrophoretics Limited.
2
Agenda
Rafael Tejada
Vice President, Investor Relations Welcome and Safe Harbor
Marc N. Casper
Chairman, President and Consistently Creating Value for All Our Stakeholders
Chief Executive Officer
Michel Lagarde
Executive Vice President and Our Leading Businesses
Chief Operating Officer
Gianluca Pettiti
Executive Vice President High-Impact Innovation
Mike Shafer
Executive Vice President The Trusted Partner to Our Customers
Fred Lowery
Executive Vice President Unparalleled Commercial Engine
Stephen Williamson
Senior Vice President and Consistently Delivering Exceptional Financial Results
Chief Financial Officer
Marc N. Casper
Chairman, President and Chief Executive Officer
Our Mission is our purpose
We enable our
customers to make
the world healthier,
cleaner and safer
5
Our Mission in action
Developed first and only FDA- Supporting a cleaner planet with Enabling customers and
cleared test for preeclampsia our air quality monitoring regulators to ensure a safe
risk stratification solutions used across the globe drug and food supply
6
Key takeaways of the day
• Incredibly well-positioned industry leader, with leading businesses that enable our
customers’ success
• We serve attractive end markets that are fueled by enduring long-term trends
• Proven growth strategy that drives share gain and a capital deployment approach
that creates tremendous value – both powered by our PPI Business System
7
World leader in serving science
$42B
revenue
>120,000 $1.3B
R&D investment
colleagues
$42.3B Revenue
Leadership in fast-growing end markets Very strong recurring revenue mix Unparalleled commercial engine
END
PRODUCTS ROW REGIONS
MARKETS
Industrial &
Applied 3%
13% Instruments
Academic &
Government 17% Asia-Pacific
Europe
Diagnostics & 19% 25%
Healthcare 15%
15%
NOTE: Revenue and percentages based on LTM through Q2 2024 9
Our four segments with industry-leading businesses
Leading portfolio serving Leading analytical Leadership in specialty Enabling biopharma with
life sciences research, technologies to enable diagnostics to cost- our leading laboratory
bioproduction, and clinical scientific breakthroughs effectively improve patient products, and clinical
markets and solve analytical care research, development, and
challenges manufacturing services
$9.5B
Revenue
$7.3B
Revenue
$4.4B
Revenue
$22.9B
Revenue
NOTE: Revenue amounts are based on LTM through Q2 2024 before intercompany eliminations 10
Industry-leading businesses, benefited by total company scale
and capabilities
LIFE SCIENCES ANALYTICAL SPECIALTY DIAGNOSTICS LABORATORY PRODUCTS
SOLUTIONS INSTRUMENTS & BIOPHARMA SERVICES
Leading portfolio serving Leading analytical Leadership in specialty Enabling biopharma with
life sciences research, technologies to enable diagnostics to cost- our leading laboratory
bioproduction, and clinical scientific breakthroughs effectively improve patient products, and clinical
markets and solve analytical care research, development, and
challenges manufacturing services
11
Consistently creating differentiated value for all our stakeholders
SHAREHOLDERS COLLEAGUES
CUSTOMERS COMMUNITIES
12
Delivering exceptional financial results
$7.0
$42.9 $21.55
$13.1
$5.40 $1.8
13
Exceptionally positioned for a terrific future
14
Exceptionally positioned for a terrific future
15
We serve very attractive end markets
$235B 4% – 6%
served long-term
market market growth
16
Our end markets are underpinned by enduring long-term trends
17
Enduring long-term trends
2023 2035
Global population
over 65 years old
18
Exceptionally positioned for a terrific future
19
Our proven growth strategy drives share gain
A• High-impact innovation 7% – 9%
Long-term organic
B• The trusted partner with industry-leading revenue growth
products, services and expertise
In normal market conditions
with underlying market
C• growth of 4% – 6%
Unparalleled commercial engine
20
A Overview of our proven innovation approach
Helios 6 Scanning
Electron Microscope
Orbitrap Astral Stellar Orbitrap Ascend
Tribrid
Thermo Scientific
Thermo Scientific mass spectrometers
B·R·A·H·M·S KRYPTOR
assays for preeclampsia
Enabling cutting-edge research and discovery Metrios 6 Scanning /
Transmission Electron
Microscope
Thermo Scientific
Gibco OncoPro Tumoroid
KingFisher PlasmidPro
Culture Medium kit Thermo Scientific instruments
and pre-filled cartridges Ion Torrent Genexus
Dx integrated
sequencer
Enabling breakthrough battery
technology
Fueling discovery and development of advanced therapeutics
Thermo Scientific
Gibco CTS Detachable Gibco CTS Xenon LInspector Edge in-line
Dynabeads platform Electroporation System mass profilometer
for cell therapy
NOTE: myeloMATCH is the National Cancer Institute’s precision medicine umbrella trial 22
B The trusted partner
Unmatched commercial
scale and reach
Leading
Industry-leading
on-site
websites, e-commerce
services
and digital capabilities
Customer and
technical support,
including applications Customer enablement
expertise centers around the world
Commercial advantage through deep engagement with customers wherever they are
24
Exceptionally positioned for a terrific future
25
Our proven capital deployment strategy
PROGRESS UPDATE
Deployed $20.4B ü Raised synergy targets in 2023; on track to exceed our synergy target of over
$200M in adjusted operating income in Year 3
PROGRESS UPDATE
ü Continuing to expand the market for multiple myeloma testing with strong
customer adoption
Deployed $2.7B
OUTLOOK
Deployed $3.1B
31
Our PPI Business System enables outstanding execution
Quality
Results
World-class
products and
Delivers
services competitive
Our culture advantage
and mindset
Productivity
engages every
Operating
colleague to and process Successful
efficiency
find a better acquisitions
way every day Customer
Allegiance
Differentiated
Maximizing
customer financial
success performance
32
Exceptionally positioned for a terrific future
33
Mission-led CSR strategy delivers competitive advantage
Using our extensive Enabling our Working to create Advancing our net-zero
capabilities to enable our colleagues to bring their positive change all over roadmap and innovating
customers while conducting best each day, working the world, focusing on to support our customers
our business and and winning together as STEM education and to achieve their
relationships with integrity one global team health equity sustainability goals
Creating long-term value and ensuring a sustainable future for all stakeholders
34
Our CSR strategy in action
COMMUNITIES ENVIRONMENT
• STEM education: • Climate:
30% 44%
Our progress
100K+ 100K+ reduction in Scope 1 & 2 of our global electricity sourced
students reached through hours volunteered emissions since 20182 from renewable energy2
STEM programs1 by colleagues1
50% 80%
Our targets
reduction in Scope 1 & 2 renewable electricity globally
emissions by 2030 by 2030
• Incredibly well-positioned industry leader, with leading businesses that enable our
customers’ success
• We serve attractive end markets that are fueled by enduring long-term trends
• Proven growth strategy that drives share gain and a capital deployment approach
that creates tremendous value – both powered by our PPI Business System
36
Our Leading
Businesses
Michel Lagarde
Executive Vice President and Chief Operating Officer
Key takeaways
• Our best-in-class products and services are essential to the work our customers do
• Our businesses have an outstanding track record of value creation and an even
brighter future
38
Our four segments with industry-leading businesses
Leading research reagents, Leading analytical technologies, Differentiated, proprietary solutions Leading provider of contract
instruments and consumables including mass spectrometry, across attractive specialty development and manufacturing
chromatography and electron diagnostics segments services
Best-in-class bioprocessing microscopy
products and equipment Leading channel serving Leading provider of clinical research
Global applications and clinical labs services
Full suite of genetic analysis instrument support
platforms Leading offering of lab
consumables, equipment
and chemicals
$9.5B
Revenue
$7.3B
Revenue
$4.4B
Revenue
$22.9B
Revenue
NOTE: Revenue amounts are based on LTM through Q2 2024 before intercompany eliminations 39
Our four segments with industry-leading businesses
Leading research reagents, Leading analytical technologies, Differentiated, proprietary solutions Leading provider of contract
instruments and consumables including mass spectrometry, across attractive specialty development and manufacturing
chromatography and electron diagnostics segments services
Best-in-class bioprocessing microscopy
products and equipment Leading channel serving Leading provider of clinical research
Global applications and clinical labs services
Full suite of genetic analysis instrument support
platforms Leading offering of lab
consumables, equipment
and chemicals
$9.5B
Revenue
$7.3B
Revenue
$4.4B
Revenue
$22.9B
Revenue
NOTE: Revenue amounts are based on LTM through Q2 2024 before intercompany eliminations 40
Life Sciences Solutions
41
Life Sciences Solutions: Financial profile
Services &
Biosciences Consumables
$9.5B
Revenue
BUSINESSES PRODUCTS
Instruments
Genetic
Sciences BioProduction 20,000
Colleagues
36%
Adj. Operating Margin
NOTE: Revenue amount is based on LTM through Q2 2024 before intercompany eliminations; adjusted operating margin is based on LTM through Q2 2024 42
Life Sciences Solutions: Segment overview
• Leading reagents, consumables and • Best-in-class bioprocessing products • Leading offering for genetic analysis
instruments for research and platforms and reagents
applied applications • Leadership position in cell culture media
and single-use technologies • Automated platform enabling
• Products of choice in life sciences labs democratization of clinical next-generation
• Rapidly growing purification and pharma sequencing (NGS)
• Excellent track record of innovation analytics businesses
• Best-in-class offering for applied markets
43
Life Sciences Solutions: Attractive market fundamentals
Scientific
• Fundamental scientific advances driving demand for innovative life science tools
advancements
Funding
• Healthy long-term funding in biopharma, academic and government research
environment
Clinical translation • Growth of clinical applications, including predictive genomics and biomarker-based cancer therapies
44
Biosciences business highlights
• Products that are essential to key scientific advances and ultimately become
Leading critical building blocks in medicines Invitrogen
portfolio SuperScript IV Reverse
• Career-long customer loyalty among researchers Transcriptase
45
BioProduction business highlights
Unique
customer • Incorporating insights from internal customers at our Pharma Services HyPerforma DynaDrive
insights manufacturing sites to advance the state-of-the-art in terms of yield and scale Single-Use Bioreactor for
commercial scale
46
Genetic Sciences business highlights
Applied Biosystems
QuantStudio 7
• Leadership positions across multiple genetic analysis technologies Real-Time PCR
• Breadth of technologies enables customers to choose the right tool for their specific
Leadership genetic sciences applications
• Vast installed base and adoption of our offerings over multiple decades drives Applied Biosystems
TaqPath qPCR
significant consumables pull-through Master Mix
• Setting the standard for genomic analysis in oncology, cell and gene therapies,
infectious diseases and other research applications
Ion Torrent Genexus for
Innovation clinical NGS testing
• Demonstrated ability to massively scale offerings for infectious disease testing
track record
• Clinical NGS platform that is democratizing NGS testing for oncology in community
and smaller hospitals
47
Our four segments with industry-leading businesses
Leading research reagents, Leading analytical technologies, Differentiated, proprietary solutions Leading provider of contract
instruments and consumables including mass spectrometry, across attractive specialty development and manufacturing
chromatography and electron diagnostics segments services
Best-in-class bioprocessing microscopy
products and equipment Leading channel serving Leading provider of clinical research
Global applications and clinical labs services
Full suite of genetic analysis instrument support
platforms Leading offering of lab
consumables, equipment
and chemicals
$9.5B
Revenue
$7.3B
Revenue
$4.4B
Revenue
$22.9B
Revenue
NOTE: Revenue amounts are based on LTM through Q2 2024 before intercompany eliminations 48
Analytical Instruments
49
Analytical Instruments: Financial profile
Chromatography &
Mass Spectrometry
Instruments
$7.3B
Revenue
BUSINESSES PRODUCTS
Chemical
Analysis Electron
16,500 Services &
Microscopy Colleagues Consumables
26%
Adj. Operating Margin
NOTE: Revenue amount is based on LTM through Q2 2024 before intercompany eliminations; adjusted operating margin is based on LTM through Q2 2024 50
Analytical Instruments: Segment overview
• Premier mass spectrometry offering • Pioneer in revolutionary cryo-EM • Large portfolio of portable analytical
technology for life sciences instruments
• Strong position in chromatography
• Cutting-edge solutions for advanced • Leading molecular and elemental
• Leading software and instrument materials spectroscopy instruments
servicing capabilities
• Leading software and instrument • Air quality and process monitoring
• Multi-decade track record of servicing capabilities instruments
groundbreaking innovations
51
Analytical Instruments: Attractive market fundamentals
Advances in life • Need for broad array of relevant analytical technologies to revolutionize our understanding of biology
sciences solutions • Strong demand for analytical instruments to power advances in structure-based drug design
Growth in advanced • Significant interest in cutting-edge analytical technologies to enable research, development and
materials manufacturing of next-gen semiconductors and breakthrough battery technologies
Greater chemical • Growth driven by new regulations, infrastructure spend and complex manufacturing processes
analysis requirements • Need for real-time data from the field driving demand for connected portable instruments
52
Chromatography and Mass Spectrometry business highlights
53
Electron Microscopy business highlights
Thermo Scientific
• Powering advances in our understanding of cellular and protein structures, and
Krios G4 Cryo-TEM
enabling structure-based drug design
Enabling
scientific • Accelerating innovations in next-gen semiconductors and breakthrough battery
advances technologies
• Integrating machine learning and AI capabilities into our instruments, enabling
greater automation and faster insight generation
54
Our four segments with industry-leading businesses
Leading research reagents, Leading analytical technologies, Differentiated, proprietary solutions Leading provider of contract
instruments and consumables including mass spectrometry, across attractive specialty development and manufacturing
chromatography and electron diagnostics segments services
Best-in-class bioprocessing microscopy
products and equipment Leading channel serving Leading provider of clinical research
Global applications and clinical labs services
Full suite of genetic analysis instrument support
platforms Leading offering of lab
consumables, equipment
and chemicals
$9.5B
Revenue
$7.3B
Revenue
$4.4B
Revenue
$22.9B
Revenue
NOTE: Revenue amounts are based on LTM through Q2 2024 before intercompany eliminations 55
Specialty Diagnostics
Leadership in specialty
diagnostics to cost-effectively
improve patient care
56
Specialty Diagnostics: Financial profile
$4.4B
Microbiology Revenue
BUSINESSES PRODUCTS
Instruments
Transplant
Diagnostics 8,500
Healthcare Colleagues
Market Channel
26%
Adj. Operating Margin
NOTE: Revenue amount is based on LTM through Q2 2024 before intercompany eliminations; adjusted operating margin is based on LTM through Q2 2024 57
Specialty Diagnostics: Segment overview
• Leading diagnostics for sepsis detection • Standard of care testing for multiple • Industry-leading in-vitro diagnostics to test
and management myeloma for hundreds of allergens
• Complete toxicology menu for drugs • Comprehensive offering of protein assays • Strong offering of diagnostics for
of abuse for immune system disorders autoimmune diseases
• Leader in pathogen detection and testing • Comprehensive solutions to enable • Leading channel serving reference
for antibiotic susceptibility patient-donor matching laboratories and hospitals in N. America
• Strong offerings for food safety testing • Launching additional post-transplant • Comprehensive offering of diagnostic
monitoring solutions products
58
Specialty Diagnostics: Attractive market fundamentals
Population • Favorable demographics driving increased demand for healthcare, including diagnostics
demographics • Increasing prevalence of complex conditions requiring specialized, accurate and reliable diagnostics
• Emergence of precision medicine driving demand for diagnostics to guide personalized treatment
Precision medicine decisions and therapy selections
• Expanded healthcare access and rising healthcare expenditures in fast-growing emerging markets
Affordability
• Increasing interest in medically relevant diagnostics to cost-effectively meet healthcare needs
59
Specialty Diagnostics business highlights
ImmunoCAP and
EliA reagents
60
Our four segments with industry-leading businesses
Leading research reagents, Leading analytical technologies, Differentiated, proprietary solutions Leading provider of contract
instruments and consumables including mass spectrometry, across attractive specialty development and manufacturing
chromatography and electron diagnostics segments services
Best-in-class bioprocessing microscopy
products and equipment Leading channel serving Leading provider of clinical research
Global applications and clinical labs services
Full suite of genetic analysis instrument support
platforms Leading offering of lab
consumables, equipment
and chemicals
$9.5B
Revenue
$7.3B
Revenue
$4.4B
Revenue
$22.9B
Revenue
NOTE: Revenue amounts are based on LTM through Q2 2024 before intercompany eliminations 61
Laboratory Products and Biopharma Services
62
Laboratory Products and Biopharma Services: Financial profile
Clinical
Research Services &
Consumables
Pharma
Services $22.9B
Revenue
BUSINESSES PRODUCTS
Instruments
Laboratory
Products 69,500
Research and Safety Colleagues
Market Channel
14%
Adj. Operating Margin
NOTE: Revenue amount is based on LTM through Q2 2024 before intercompany eliminations; adjusted operating margin is based on LTM through Q2 2024 63
Laboratory Products and Biopharma Services: Segment overview
• Leading contract • Leading clinical research • Comprehensive offering of lab • Premier scientific marketplace
development and services with comprehensive consumables, equipment providing choice, convenience
manufacturing services offering and chemicals and aggregation services
• Expertise across small • Expertise across therapeutic • Offerings used in every lab, • Industry-leading websites,
molecules, biologics and areas, advanced modalities every day e-commerce and digital
advanced therapies and multiple trial types capabilities
64
Laboratory Products and Biopharma Services:
Attractive market fundamentals
Strong underlying • Scientific advancements and demand for innovative medicines fueling robust drug pipeline
trends • Healthy long-term funding and regulatory environment
• Fragmented customer base looking to purchase 1000s of SKUs quickly and seamlessly – allowing
Customer need for customers to focus on their scientific work
productivity
• Leveraging economies of scale in procuring lab supplies through an effective channel provider
• Customers seeking to accelerate timelines, drive efficiencies and access expertise across drug
Continued trend development, clinical research and commercialization
towards outsourcing
• Strong demand from emerging biotech customers who lack these capabilities
and partnering
• Flexible access to capacity to rapidly scale up for commercial manufacturing
65
Our Pharma Services business highlights
Scale and • Scale footprint with 60+ sites in key geographies and 2,700 scientists and
depth of engineers
expertise • Global network of clinical trial supply sites
• Leading global clinical research services (CRO) with outstanding reputation for
Industry innovation and quality
leadership • Comprehensive CRO offering with industry-leading execution across the clinical
research process – from patient enrollment to post-approval services
Accumulated • Worked with all major pharma companies1 and thousands of biotechs
experience • Supported 2,800+ trials and 660+ drug approvals in the past five years
Broadest • >2.5 million products from Thermo Fisher and 9,000 external suppliers
portfolio
68
Our four segments with industry-leading businesses
Leading research reagents, Leading analytical technologies, Differentiated, proprietary solutions Leading provider of contract
instruments and consumables including mass spectrometry, across attractive specialty development and manufacturing
chromatography and electron diagnostics segments services
Best-in-class bioprocessing microscopy
products and equipment Leading channel serving Leading provider of clinical research
Global applications and clinical labs services
Full suite of genetic analysis instrument support
platforms Leading offering of lab
consumables, equipment
and chemicals
$9.5B
Revenue
$7.3B
Revenue
$4.4B
Revenue
$22.9B
Revenue
NOTE: Revenue amounts are based on LTM through Q2 2024 before intercompany eliminations 69
Industry-leading businesses, benefited by total company scale
and capabilities
LIFE SCIENCES ANALYTICAL SPECIALTY DIAGNOSTICS LABORATORY PRODUCTS
SOLUTIONS INSTRUMENTS & BIOPHARMA SERVICES
Leading portfolio serving Leading analytical Leadership in specialty Enabling biopharma with
life sciences research, technologies to enable diagnostics to cost- our leading laboratory
bioproduction, and clinical scientific breakthroughs effectively improve patient products, and clinical
markets and solve analytical care research, development, and
challenges manufacturing services
70
Our PPI Business System enables outstanding execution
Quality
Results
World-class
products and
Delivers
services competitive
Our culture advantage
and mindset
Productivity
engages every
Operating
colleague to and process Successful
efficiency
find a better acquisitions
way every day Customer
Allegiance
Differentiated
Maximizing
customer financial
success performance
71
PPI in practice: Driving efficiencies
INVENTORY AND SUPPLY CHAIN MANUFACTURING QUALITY
MATERIALS PLANNING OPERATIONS
• Enhanced sales, inventory • Spend analytics and • Manufacturing automation • Improvements in right-first-
and operations planning strategic sourcing capability time performance
capabilities • Reductions in downtime
• Digital supply chain and changeovers • Predictive deviations
management management
• De-bottlenecking
• Warehousing automation
• Increasing use of AI and digital tools to drive higher accuracy and quality, and to enable automation
• Effectively using data and a common data platform to enable real-time performance management
72
PPI in practice: Driving efficiencies
INVENTORY AND SUPPLY CHAIN MANUFACTURING QUALITY
MATERIALS PLANNING OPERATIONS
• Increasing use of AI and digital tools to drive higher accuracy and quality, and to enable automation
• Effectively using data and a common data platform to enable real-time performance management
NOTE: 1) Last four quarters; 2) LTM ending Aug 2024; 3) From 2021-2023; 4) From Jan 2023 - Jun 2024 73
PPI in practice: Leveraging AI to enhance our business processes
• Our best-in-class products and services are essential to the work our customers do
• Our businesses have an outstanding track record of value creation and an even
brighter future
75
High-Impact
Innovation
Gianluca Pettiti
Executive Vice President
Our proven growth strategy drives share gain
A• High-impact innovation
77
Key takeaways
• We play a crucial role in enabling the development and scaling of major scientific
advances by our customers
78
A Overview of our proven innovation approach
$1.3B 7,200 R&D scientists World-leading patents
R&D investment and engineers and IP portfolio
80
Our innovation enables major scientific breakthroughs
ENABLING THE GOLDEN AGE OF BIOLOGY ENABLING PRECISION MEDICINE
• Providing highly
differentiated precision
• Enabling cutting-edge diagnostic solutions
research and discovery
• Enabling highly targeted
therapy selection and early
detection of diseases
• Powering high-throughput
translational applications
ENABLING ADVANCED MATERIALS
• Supporting development of
next-gen semiconductors
• Enabling the future of
medicine from development
to manufacturing • Enabling breakthrough
battery technology and
nanomaterials
81
Our innovation enables major scientific breakthroughs
ENABLING THE GOLDEN AGE OF BIOLOGY ENABLING PRECISION MEDICINE
• Providing highly
differentiated precision
• Enabling cutting-edge diagnostic solutions
research and discovery
• Enabling highly targeted
therapy selection and early
detection of diseases
• Powering high-throughput
translational applications
ENABLING ADVANCED MATERIALS
• Supporting development of
next-gen semiconductors
• Enabling the future of
medicine from development
to manufacturing • Enabling breakthrough
battery technology and
nanomaterials
82
GOLDEN AGE OF BIOLOGY
Enabling cutting-edge
research and discovery
Gibco OncoPro Tumoroid Thermo Scientific KingFisher PlasmidPro
Culture Medium kit and pre-filled cartridges
Furthering advances
in proteomics
Orbitrap Astral Stellar Orbitrap Ascend Tribrid
Enabling cutting-edge
research and discovery
Gibco OncoPro Tumoroid Thermo Scientific KingFisher PlasmidPro
Culture Medium kit and pre-filled cartridges
Furthering advances
in proteomics
Orbitrap Astral Stellar Orbitrap Ascend Tribrid
STRUCTURAL SPATIAL
• Designing new drug candidates
BIOLOGY PROTEOMICS
• Developing new diagnostic biomarkers
Understanding 3D Studying protein locations
structures of proteins within tissues and cells
Ardia
Thermo Scientific EasyPep Thermo Scientific Stellar Olink Explore HT Olink Signature Q100
MS Sample Prep kits Mass Spectrometer biomarker panels benchtop instrument
CRYO-EM SOFTWARE
STRUCTURAL BIOLOGY SPATIAL PROTEOMICS Smart EPU
Thermo Scientific
SMART Digest
Trypsin kit
Suite of analytical software
Thermo Scientific Tandem for data management and
Mass Tag (TMT) reagents Thermo Scientific Krios Invitrogen Alexa Fluor Invitrogen ViewRNA
insight generation
G4 Cryo-TEM Tyramide SuperBoost kits Colorimetric Tissue Core kit
Unmatched leadership with a comprehensive portfolio across all areas of proteomics research
NOTE: UHPLC = ultra high-performance liquid chromatography, TEM = transmission electron microscopy 87
GOLDEN AGE OF BIOLOGY
Thermo Scientific
Tandem Mass Tag (TMT) Invitrogen ViewRNA
reagents for sample prep
Colorimetric Tissue Core kit
• 4x higher throughput • Protein validation at scale with • First ever determination of protein • Superior sensitivity and specificity
FUNCTIONAL exceptional analytical specificity structure at atomic resolution for spatial proteomics applications
ADVANTAGES • 2x increase in protein coverage
and higher sensitivity • Unrivaled efficiency with minimal • 30% faster throughput
sample volume needs
WHY IT • Enables large scale discovery of • High throughput enables • Enables molecular-scale • Provides comprehensive portfolio
MATTERS proteins and protein changes population-scale studies visualization – revolutionizing of reagents to enable spatial
structure-based drug design proteomics research
• Providing highly
differentiated precision
• Enabling cutting-edge diagnostic solutions
research and discovery
• Enabling highly targeted
therapy selection and early
detection of diseases
• Powering high-throughput
translational applications
ENABLING ADVANCED MATERIALS
• Supporting development of
next-gen semiconductors
• Enabling the future of
medicine from development
to manufacturing • Enabling breakthrough
battery technology and
nanomaterials
89
PRECISION MEDICINE
Transplant diagnostics
• Diagnostics that facilitate the • Pre-transplant assays to better match patients to donors
administration of personalized and • Leading assays to monitor post-transplant graft rejection
targeted therapies One Lambda C1qScreen assay
Preeclampsia diagnostics
• First-of-its-kind preeclampsia test in the United States
B·R·A·H·M·S KRYPTOR
assays for preeclampsia
• Providing highly
differentiated precision
• Enabling cutting-edge diagnostic solutions
research and discovery
• Enabling highly targeted
therapy selection and early
detection of diseases
• Powering high-throughput
translational applications
ENABLING ADVANCED MATERIALS
• Supporting development of
next-gen semiconductors
• Enabling the future of
medicine from development
to manufacturing • Enabling breakthrough
battery technology and
nanomaterials
91
ADVANCED MATERIALS
• We play a crucial role in enabling the development and scaling of major scientific
advances by our customers
93
The Trusted Partner
to Our Customers
Mike Shafer
Executive Vice President
Our proven growth strategy drives share gain
A• High-impact innovation
95
Key takeaways
• Our trusted partner status creates new opportunities and drives share gain
96
The trusted partner
98
Trusted partner in action: Pharma and biotech
• On average, it takes 10+ years and ~$2B to bring a new drug to market
• On average, it takes 10+ years and ~$2B to bring a new drug to market
101
1 Our leading Pharma Services business
OUR VALUE PROPOSITION
• Comprehensive offering
OUR DIFFERENTIATION
NOTE: Revenue amount is based on LTM through Q2 2024 before intercompany eliminations 102
2 Our leading Clinical Research business
OUR VALUE PROPOSITION
• Comprehensive offering
$8B
Clinical trial Analytical lab Real-world evidence Consulting services
management testing services & digital capabilities for clinical trials
OUR DIFFERENTIATION
• Industry-leading execution across the clinical research process – from patient enrollment to post-approval services
NOTE: Revenue amount is based on LTM through Q2 2024 before intercompany eliminations 103
1 2 Our leading services businesses by the numbers
Pharma Services 50
sites globally pharma companies in the
past five years1
Operated clinical
trials across
LEADING TALENT Worked with
120+ EXPERTISE & EXPERIENCE
2,700+
20K countries in the
past five years Experience
supporting
Experience
supporting
biotech companies in
the past five years
colleagues in
Pharma Services
660+ 30+
drug approvals in therapeutic
• Simplified and accelerated clinical trial processes with central point of contact
World-class capabilities accelerating speed-to-market and unlocking value for our customers
105
3 Powerful combination in action: Customer case-studies
• Our trusted partner status creates new opportunities and drives share gain
107
Unparalleled
Commercial
Engine
2024 Investor Day
September 19, 2024
Fred Lowery
Executive Vice President
Our proven growth strategy drives share gain
A• High-impact innovation
7% – 9%
B• The trusted partner with industry-leading Long-term organic
products, services and expertise revenue growth
109
Key takeaways
• Our Research and Safety Market Channel is the ultimate channel partner
for our customers allowing them to focus on their high value work
110
Unparalleled commercial engine
Unmatched commercial
scale and reach
Leading
Industry-leading
on-site
websites, e-commerce
services
and digital capabilities
Customer and
technical support,
including applications Customer enablement
expertise centers around the world
Commercial advantage through deep engagement with customers wherever they are
111
Unmatched commercial scale and reach
OUR CUSTOMERS OUR ENGAGEMENT
Senior executives
C-Suite Senior-level strategic goal alignment
Thousands
of touchpoints
with customers every day
>9,500
Front-line leaders / Business-specific salesforces commercial colleagues
Deep scientific, medical and applications expertise
users
(Procurement, scientists,
lab managers, clinical trial managers, Channel-specific salesforces
operations managers) Continuous customer engagement
Unmatched insights to better serve our customers and drive commercial effectiveness
112
Industry-leading websites, e-commerce and digital capabilities
INDUSTRY-LEADING WEBSITES
TAILORED ENGAGEMENT
AND E-COMMERCE
thermofisher.com fishersci.com
• Deep scientific and applications content • Rich set of customer purchasing and behavior data
• Unmatched portfolio breadth consisting of proprietary, • AI-enabled personalization driving highly relevant
franchised and third-party products customer engagement and offers
• Seamless buying experience
• Greener Choice program enables customers to select
products based on sustainability impact
Customer Enablement
Centers • Showcasing our instruments and
equipment in relevant workflows
Bioprocessing
Design Centers
• Staffed by technical and
Material Sciences
applications specialists
Customer Enablement
Centers
• Visits and education sessions with
well-respected external key
Pharma Services opinion leaders
Development sites
CUSTOMER BENEFITS
Hands-on engagement with Ability to run customer samples Workshops and training Access to industry key
our products and services to evaluate our products sessions with experts opinion leaders
Providing expertise and driving productivity by freeing up customers to focus on their critical work
115
Commercial engine in action: Our Research and Safety Market Channel
FIT-FOR-PURPOSE
BROADEST PORTFOLIO TRANSACTIONAL EFFICIENCY
INFRASTRUCTURE AND SERVICES
Chemicals
Integrated logistics storage and handling Technical and applications
and delivery support
• Our Research and Safety Market Channel is the ultimate channel partner
for our customers allowing them to focus on their high value work
118
Consistently Delivering
Exceptional Financial
Results
2024 Investor Day
September 19, 2024
Stephen Williamson
Senior Vice President and Chief Financial Officer
Very attractive long-term financial profile
• Proven growth strategy enables customer success and drives share gain
121
Agenda
122
Delivering exceptional financial results
$7.0
$42.9 $21.55
$13.1
$5.40 $1.8
$42.3B Revenue
Leadership in fast-growing end markets Very strong recurring revenue mix Unparalleled commercial engine
END
PRODUCTS ROW REGIONS
MARKETS
Industrial &
Applied 3%
13% Instruments
Academic &
Government 17% Asia-Pacific
Europe
Diagnostics & 19% 25%
Healthcare 15%
15%
NOTE: Revenue and percentages based on LTM through Q2 2024 124
Agenda
125
2024 Full-year guidance: Summary
2024 GUIDANCE*
127
Agenda
128
Long-term financial outlook framing
• Incredibly well-positioned industry leader serving customers in very attractive end markets
• All powered by our PPI Business System and an experienced team with great depth of talent
132
Very attractive long-term financial profile
• Proven growth strategy enables customer success and drives share gain
Appendix
Marc Casper has been President and Chief Executive Officer of Thermo Fisher Scientific since October 2009.
He was also elected Chairman of the Board in February 2020.
Marc joined Thermo Electron Corporation in 2001 as vice president of the Life Sciences sector. He was named
senior vice president in 2003, and in 2005 assumed responsibility for all of the company’s operating divisions. After
the merger creating Thermo Fisher Scientific in 2006, Marc was named executive vice president and president
of its Analytical Technologies businesses, and in 2008 he became the company’s Chief Operating Officer.
Prior to joining Thermo Fisher, Marc served as president, chief executive officer and a director of Kendro Laboratory
Products. Previously, he worked for clinical diagnostics provider Dade Behring Inc., serving as president–Americas.
Marc began his career as a strategy consultant at Bain & Company and later joined Bain Capital.
Marc serves on the boards of Wesleyan University, Mass General Brigham, Synopsys, Inc. and The Board of Dean's
Advisors at Harvard Business School. He is also Chairman Emeritus of the U.S. -China Business Council.
Previously, he was a director of the Advisory Board Company, Zimmer Holdings, U.S. Bancorp and Brigham &
Women's Hospital. Marc earned an MBA with high distinction from Harvard Business School and is a graduate
of Wesleyan University, where he received a bachelor’s degree in economics.
135
Michel Lagarde
Executive Vice President and Chief Operating Officer
Michel was named Executive Vice President in September 2019 and became Chief Operating Officer in January
2022. Michel has responsibility for Thermo Fisher’s Pharma Services, Clinical Research, BioProduction, Laboratory
Products and Customer Channels businesses, as well as our regions, Corporate Accounts function and Chief
Medical Office. He joined the company as President, Pharma Services, through the acquisition of Patheon in 2017.
Michel previously served as President and Chief Operating officer of Patheon from 2016 to 2017, and prior to that,
he was Managing Director at JLL Partners, a leading middle-market private equity firm focused on healthcare.
At JLL, Michel worked with several of the organization’s portfolio companies, including Patheon, where he helped
the executive committee transform the company into a global provider of biopharma development and commercial
manufacturing services.
Before joining JLL, Michel was Chief Executive Officer and Chief Financial Officer (CFO) of the Domestic Appliances
and Personal Care division of Philips Electronics North America. He also previously served as CFO of Philips
Electronics in Indonesia and Financial Controller of Philips Electronics Hong Kong.
Michel is a member of the Board of Directors of Vertex Pharmaceuticals. He earned a bachelor’s degree in
business administration from European University in Antwerp and an executive master’s degree in finance and
control from the University of Maastricht and University of Amsterdam.
136
Gianluca Pettiti
Executive Vice President and President, Life Sciences, Diagnostics and Applied
Gianluca became Executive Vice President and President, Life Sciences, Diagnostics and Applied in April 2024. In
this role, Gianluce has oversight for the Life Sciences Solutions, Specialty Diagnostics and Analytical Instruments
as well as our Chief Scientific Office and Quality & Regulatory Affairs function. Gianluca was appointed Executive
Vice President in January 2022. He previously served as Senior Vice President and President, Specialty
Diagnostics, assuming additional responsibility for our clinical next-generation sequencing business. Gianluca joined
the company through the acquisition of Life Technologies in 2014, where he served as President, Greater China.
From 2015 through 2017, he led Thermo Fisher’s business in China, and became President, Biosciences, in 2018.
Gianluca began his career with General Electric and joined Life Technologies in 2006, serving in finance leadership
roles in Europe before becoming Vice President and General Manager of the Latin America business in 2010 and
assuming leadership of Greater China in 2013.
Gianluca earned a Master of Science degree in engineering from Politecnico di Torino in Italy. He served as a
member of the Global Future Council on Health and Healthcare of the World Economic Forum from 2016 to 2018.
137
Mike Shafer
Executive Vice President and President, Biopharma Services
Mike became Executive Vice President and President, Biopharma Services in April 2024. In this role, he has
responsibility for our Pharma Services and Clinical Research businesses. Prior to this role, Mike was Senior Vice
President and President of our Pharma Services business since October 2019. He joined Thermo Fisher in 2009 as
Vice President and General Manager of China and was named President of China in 2012. In 2015, Mike was
appointed President of the Chemical Analysis business, and in 2016, following the acquisition of FEI Company, he
became President, Materials and Structural Analysis.
Prior to joining Thermo Fisher, Mike worked at 3M Company for more than 15 years, managing various industrial
and electronics businesses. With 3M, he spent seven years in the Asia-Pacific region, serving as APAC Business
Director for the company’s Industrial & Transportation Businesses as well as APAC Electronics Market Materials
Division Manager.
Mike earned his Bachelor of Arts degree from the University of Minnesota.
138
Fred Lowery
Executive Vice President and President, Laboratory Products and BioProduction
Fred became Executive Vice President and President, Laboratory Products and BioProduction in April 2024. In this
role, Fred has responsibility for our Laboratory Products, Customer Channels and BioProduction businesses. Prior
to this role, he served as Senior Vice President and President, Customer Channels since January 2021. He joined
the company in 2005 as head of operations for the Molecular BioProducts business of Fisher Scientific International.
When Fisher Scientific merged with Thermo Electron in 2006, Fred was named Vice President and General
Manager of the Chromatography Consumables and Specialty Glass business.
In 2010, he became Vice President and General Manager of the Life Science Research business and in 2011 was
named President, Laboratory Consumables. In 2014, Fred was named Senior Vice President and President,
Laboratory Products, and in 2016 he also became Senior Operating Officer, Life Sciences Solutions. In 2017, he
became President, Life Sciences Solutions and Laboratory Products.
Earlier in his career, Fred worked for Maytag Corporation and General Motors.
Fred serves on the Board of Directors for DuPont and the Board of Trustees for Boston Medical Center as well as
Tennessee Technology University and its Foundation. He holds a master’s degree in manufacturing management
from Kettering University (formerly General Motors Institute of Engineering and Management) and a bachelor’s
degree in mechanical engineering from Tennessee Technological University.
139
Stephen Williamson
Senior Vice President and Chief Financial Officer
In August 2015, Stephen was named Senior Vice President and Chief Financial Officer, responsible for the
company’s finance, tax, M&A, treasury, and global business services functions. He joined the company in 2001 as
Vice President, European Financial Operations, based in the U.K., and oversaw the company’s integration activities
across Europe. In 2004, Stephen moved to the U.S. and held finance leadership roles for a number of the
company’s operating businesses. In 2008, he became Vice President of Financial Operations for Thermo Fisher
Scientific and led the finance support function for all of the company’s businesses.
Stephen joined Thermo Fisher from Honeywell International (formerly AlliedSignal), where he served as Vice
President and Chief Financial Officer, Asia-Pacific, in Singapore and held other finance roles in corporate
development and operational finance. He began his career with Price Waterhouse in the transaction support group
and the audit practice, working in both London and New York.
Stephen holds a bachelor's degree in accounting and finance from the University of Wales and is a member of the
Institute of Chartered Accountants of England and Wales.
140
2024
Investor Day Sept 19, 2024
GAAP/Non-GAAP
Reconciliation and
Financial Package
We report adjusted gross margin, adjusted SG&A expense, adjusted EBITDA, adjusted operating income, adjusted operating margin, adjusted other expense/income, adjusted tax rate, adjusted net income, and adjusted EPS. We believe that the
use of these non-GAAP financial measures, in addition to GAAP financial measures, helps investors to gain a better understanding of our core operating results and future prospects, consistent with how management measures and forecasts the
company’s core operating performance, especially when comparing such results to previous periods, forecasts, and to the performance of our competitors. Such measures are also used by management in their financial and operating decision-
making and for compensation purposes. To calculate these measures we exclude, as applicable:
• Certain acquisition-related costs, including charges for the sale of inventories revalued at the date of acquisition, significant transaction/acquisition-related costs, including changes in estimates of contingent acquisition-related
consideration, and other costs associated with obtaining short-term financing commitments for pending/recent acquisitions. We exclude these costs because we do not believe they are indicative of our normal operating costs.
• Costs/income associated with restructuring activities and large-scale abandonments of product lines, such as reducing overhead and consolidating facilities. We exclude these costs because we believe that the costs related to
restructuring activities are not indicative of our normal operating costs.
• Discontinued operations; equity in earnings/losses of unconsolidated entities; impairments of long-lived assets; and certain other gains and losses that are either isolated or cannot be expected to occur again with any predictability,
including gains/losses on investments, the sale of businesses, product lines, and real estate, significant litigation-related matters, curtailments/settlements of pension plans, and the early retirement of debt. We exclude these items because
they are outside of our normal operations and/or, in certain cases, are difficult to forecast accurately for future periods.
• The depreciation of property, plant and equipment. Exclusion of depreciation expense allows comparisons of operating results that are consistent over time for both our capital intensive and other businesses.
• The expense associated with the amortization of acquisition-related intangible assets because a significant portion of the purchase price for acquisitions may be allocated to intangible assets that have lives of up to 20 years. Exclusion of
the amortization expense allows comparisons of operating results that are consistent over time for both our newly acquired and long-held businesses and with both acquisitive and non-acquisitive peer companies.
• The noncontrolling interest and tax impacts of the above items and the impact of significant tax audits or events (such as changes in deferred taxes from enacted tax rate/law changes), the latter of which we exclude because they are
outside of our normal operations and difficult to forecast accurately for future periods.
We report free cash flow, which is operating cash flow from continuing operations excluding net capital expenditures, to provide a view of the continuing operations’ ability to generate cash for use in acquisitions and other investing and financing
activities. The company also uses this measure as an indication of the strength of the company. Free cash flow is not a measure of cash available for discretionary expenditures since we have certain non-discretionary obligations such as debt
service that are not deducted from the measure.
We define net debt as total debt less cash, cash equivalents and, beginning in 2024, short-term investments. We have recast prior periods to conform to the current presentation. We believe net debt is meaningful to investors as the company
considers net debt and its components to be important indicators of liquidity and financial position.
We define adjusted ROIC as trailing twelve months' adjusted net income excluding net interest expense, net of tax benefit therefrom, divided by trailing five quarters' average invested capital, which is equity plus short-term and long-term debt and
net liabilities of discontinued operations less cash, cash equivalents, short-term investments, and equity method investments. We define adjusted ROE as trailing twelve months' adjusted net income excluding interest expense, net of tax benefit
therefrom, divided by trailing five quarters' average equity. We believe these measures are meaningful to investors as they focus on shareholder value creation.
Thermo Fisher Scientific does not provide GAAP financial measures on a forward-looking basis because we are unable to predict with reasonable certainty and without unreasonable effort items such as the timing and amount of future
restructuring actions and acquisition-related charges as well as gains or losses from sales of real estate and businesses, the early retirement of debt and the outcome of legal proceedings. The timing and amount of these items are uncertain and
could be material to Thermo Fisher Scientific’s results computed in accordance with GAAP.
The non-GAAP financial measures of Thermo Fisher Scientific’s results of operations and cash flows included herein are not meant to be considered superior to or a substitute for Thermo Fisher Scientific’s results of operations prepared in
accordance with GAAP. Reconciliations of such non-GAAP financial measures to the most directly comparable GAAP financial measures are set forth in the accompanying tables.
Certain amounts and percentages reported herein are presented and calculated based on underlying unrounded amounts. As a result, the sum of components may not equal corresponding totals due to rounding.
Page 2
Table of Contents
Page
4 Annual Reconciliation of Adjusted P&L (2021 - 2023)
6 Annual Reconciliation of Adjusted EBITDA (2021 - 2023)
7 Quarterly Reconciliation of Adjusted P&L and Free Cash Flow (2023 - 2024)
9 Quarterly Reconciliation of Adjusted EBITDA (2023 - 2024)
10 Free Cash Flow, Adjusted Return on Invested Capital and Adjusted Return on Equity (2021 - 2024)
11 Reconciliation of Adjusted EPS and Free Cash Flow (2013)
12 Reconciliation of Core Organic Revenue Growth (2022 - 2024)
13 Business Segment Information (2023 - 2024)
14 Balance Sheets and Leverage Ratios (2021 - 2024)
15 Debt (2021 - 2024)
17 Notable Acquisitions (2021 - 2024)
18 Capital Deployment (2021 - 2024)
19 Fiscal Calendar (2024)
Page 3
Annual Reconciliation of Adjusted P&L
$ % $ % $ %
(a) Adjusted results exclude charges for the sale of inventories revalued at the date of acquisition; in 2022 and 2023, charges for inventory write-downs associated with large-scale abandonment of product lines; and in 2023, accelerated depreciation on manufacturing assets to be abandoned due to facility consolidations.
(b) Adjusted results exclude certain third-party expense, principally transaction/integration costs (including reimbursements thereof) related to recent/terminated acquisitions; charges/credits for changes in estimates of contingent acquisition consideration; and charges associated with product liability litigation.
(c) Adjusted results exclude restructuring and other costs consisting principally of severance, abandoned facility and other expenses of headcount reductions and real estate consolidation; impairments of long-lived assets; significant gains and losses on litigation-related matters; gains on the sale of businesses, product lines and
property; charges/credits for environmental-related matters; in 2021, charges for compensation due to employees of acquired businesses at the date of acquisition; in 2022, a gain on the sale of intellectual property; and in 2023, contract termination costs associated with facility closures, charges for pre-acquisition litigation and
other matters, and gains on the sale of real estate.
Page 4
Annual Reconciliation of Adjusted P&L
(Dollars in millions except EPS) 2021 2022 2023
$ % $ % $ %
Reconciliation of adjusted tax provision
GAAP tax provision 1,109 12.5% 703 9.0% 284 4.5%
Tax effect of adjusted items (e) 593 2.1% 672 4.0% 645 5.5%
Adjusted tax provision (non-GAAP measure) 1,702 14.6% 1,375 13.0% 929 10.0%
Page 5
Annual Reconciliation of Adjusted EBITDA
(a) Adjusted results exclude charges for the sale of inventories revalued at the date of acquisition; in 2022 and 2023, charges for inventory write-downs associated with large-scale abandonment of product lines; and in
2023, accelerated depreciation on manufacturing assets to be abandoned due to facility consolidations.
(b) Adjusted results exclude certain third-party expense, principally transaction/integration costs (including reimbursements thereof) related to recent/terminated acquisitions; charges/credits for changes in estimates of
contingent acquisition consideration; and charges associated with product liability litigation.
(c) Adjusted results exclude restructuring and other costs consisting principally of severance, abandoned facility and other expenses of headcount reductions and real estate consolidation; impairments of long-lived
assets; significant gains and losses on litigation-related matters; gains on the sale of businesses, product lines and property; charges/credits for environmental-related matters; in 2021, charges for compensation due to
employees of acquired businesses at the date of acquisition; in 2022, a gain on the sale of intellectual property; and in 2023, contract termination costs associated with facility closures, charges for pre-acquisition
litigation and other matters, and gains on the sale of real estate.
Page 6
Quarterly Reconciliation of Adjusted P&L and Free Cash Flow
(Dollars in millions except EPS) Q1-23 Q2-23 Q3-23 Q4-23 Q1-24 Q2-24
Revenue
Life Sciences Solutions Segment $2,612 $2,463 $2,433 $2,469 $2,285 $2,355
Analytical Instruments Segment 1,723 1,749 1,754 2,037 1,687 1,782
Specialty Diagnostics Segment 1,108 1,109 1,083 1,105 1,109 1,117
Laboratory Products and Biopharma Services Segment 5,763 5,831 5,728 5,719 5,723 5,758
Eliminations (496) (465) (424) (444) (460) (470)
Total revenue 10,710 10,687 10,574 10,886 10,345 10,541
$ % $ % $ % $ % $ % $ %
GAAP R&D expense 346 3.2% 345 3.2% 319 3.0% 327 3.0% 331 3.2% 339 3.2%
(a) Adjusted results exclude charges for inventory write-downs associated with large-scale abandonment of product lines; in 2023, charges for the sale of inventories revalued at the date of acquisition; and in Q2 2023, Q3 2023 and Q4 2023, accelerated depreciation on on manufacturing assets to be abandoned due to facility consolidations.
(b) Adjusted results exclude certain third-party expenses, principally transaction/integration costs related to recent acquisitions; charges/credits for changes in estimates of contingent acquisition consideration; and in Q3 2023 and Q4 2023, charges associated with product liability litigation.
(c) Adjusted results exclude restructuring and other costs consisting principally of severance, abandoned facility and other expenses of headcount reductions and real estate consolidation; impairments of long-lived assets; significant gains and losses on litigation-related matters; gains on the sale of businesses, product lines and property; net charges for pre-acquisition litigation and
other matters; in Q2 2023, contract termination costs associated with facility closures; and in Q3 2023 and Q4 2023, gains on the sale of real estate.
Page 7
Quarterly Reconciliation of Adjusted P&L and Free Cash Flow
(Dollars in millions except EPS) Q1-23 Q2-23 Q3-23 Q4-23 Q1-24 Q2-24
$ % $ % $ % $ % $ % $ %
(a) Adjusted results exclude charges for inventory write-downs associated with large-scale abandonment of product lines; in 2023, charges for the sale of inventories revalued at the date of acquisition; and in Q2 2023, Q3 2023 and Q4 2023, accelerated depreciation on on manufacturing assets to be abandoned due to facility consolidations.
(b) Adjusted results exclude certain third-party expenses, principally transaction/integration costs related to recent acquisitions; charges/credits for changes in estimates of contingent acquisition consideration; and in Q3 2023 and Q4 2023, charges associated with product liability litigation.
(c) Adjusted results exclude restructuring and other costs consisting principally of severance, abandoned facility and other expenses of headcount reductions and real estate consolidation; impairments of long-lived assets; significant gains and losses on litigation-related matters; gains on the sale of businesses, product lines and property; net charges for pre-acquisition litigation and other matters; in
Q2 2023, contract termination costs associated with facility closures; and in Q3 2023 and Q4 2023, gains on the sale of real estate.
(d) Adjusted results exclude net gains/losses on investments.
(e) Adjusted results exclude the incremental impacts for the reconciling items between GAAP and adjusted net income; incremental tax impacts as a result of tax rate/law changes; the tax impacts from audit settlements; and in Q4 2023, charges for pre-acquisition matters.
(f) Adjusted results exclude the incremental impacts for the reconciling items between GAAP and adjusted net income attributable to noncontrolling interests.
Page 8
Quarterly Reconciliation of Adjusted EBITDA
(a) Adjusted results exclude charges for inventory write-downs associated with large-scale abandonment of product lines; in 2023, charges for the sale of inventories revalued at the date of acquisition; and in Q2 2023, Q3 2023 and Q4 2023, accelerated depreciation on on manufacturing assets to be abandoned due to facility
consolidations.
(b) Adjusted results exclude certain third-party expenses, principally transaction/integration costs related to recent acquisitions; charges/credits for changes in estimates of contingent acquisition consideration; and in Q3 2023 and Q4 2023, charges associated with product liability litigation.
(c) Adjusted results exclude restructuring and other costs consisting principally of severance, abandoned facility and other expenses of headcount reductions and real estate consolidation; impairments of long-lived assets; significant gains and losses on litigation-related matters; gains on the sale of businesses, product lines and
property; net charges for pre-acquisition litigation and other matters; in Q2 2023, contract termination costs associated with facility closures; and in Q3 2023 and Q4 2023, gains on the sale of real estate.
Page 9
Free Cash Flow, Adjusted Return on Invested Capital and Adjusted Return on Equity
(a) Adjusted results exclude; in 2021, 2022 and 2023, charges for the sale of inventories revalued at the date of acquisition; in 2022, 2023 and 2024, charges for inventory write-downs associated with large-scale abandonment of product lines; and in 2023, accelerated depreciation on manufacturing assets to be
abandoned due to facility consolidations.
(b) Adjusted results exclude certain third-party expense, principally transaction/integration costs (including reimbursements thereof) related to recent/terminated acquisitions; charges/credits for changes in estimates of contingent acquisition consideration; and charges associated with product liability litigation.
(c) Adjusted results exclude restructuring and other costs consisting principally of severance, abandoned facility and other expenses of headcount reductions and real estate consolidation; impairments of long-lived assets; significant gains and losses on litigation-related matters; gains on the sale of businesses,
product lines and property; charges/credits for environmental-related matters; in 2023 and 2024, charges for pre-acquisition litigation and other matters; in 2021, charges for compensation due to employees of acquired businesses at the date of acquisition; in 2022, a gain on the sale of intellectual property; and
in 2023, contract termination costs associated with facility closures, and gains on the sale of real estate.
(d) Adjusted results exclude net gains/losses on investments; in 2021 and 2022, losses on the extinguishment of debt; in 2021, costs to obtain short-term financing commitments related to recent/terminated acquisitions; and in 2022, net gains on derivative instruments to address certain foreign currency risks.
(e) Adjusted results exclude incremental tax impacts for the reconciling items between GAAP and adjusted net income; incremental tax impacts as a result of tax rate/law changes; the tax impacts from audit settlements; in 2022, the impact of deferred tax realizability assessments as a result of audit settlements;
and in 2023, charges for pre-acquisition matters.
(f) Adjusted results exclude the incremental impacts for the reconciling items between GAAP and adjusted net income attributable to noncontrolling interests.
Page 10
Reconciliation of Adjusted EPS and Free Cash Flow (2013)
(a) Adjusted results exclude charges for the sale of inventories revalued at the date of acquisition and accelerated depreciation on assets to be abandoned due to facility consolidations.
(b) Adjusted results exclude significant transaction/integration costs related to recent acquisitions; charges/credits for changes in estimates of contingent acquisition consideration; and charges
associated with product liability litigation.
(c) Adjusted results exclude severance and retention costs; abandoned facility and other expenses of real estate consolidation; impairments of long-lived assets; and significant gains and losses on
litigation-related matters.
(d) Adjusted results exclude net gains/losses on investments and costs to obtain short-term financing commitments related to acquisitions.
(e) Adjusted results exclude incremental tax impacts for the reconciling items between GAAP and adjusted net income; incremental tax impacts as a result of tax rate/law changes; and the impact of
the resolution of significant tax audits.
Page 11
Reconciliation of Core Organic Revenue Growth
Revenue growth 15% -9% -3% -1% -5% -5% -3% -1%
Impact of acquisitions 18% 1% 1% 1% 1% 1% 0% 0%
Impact of currency translation -3% -2% 0% 1% 1% 0% 0% -1%
Organic revenue growth (non-GAAP measure) 0% -8% -3% -3% -7% -5% -4% -1%
Impact of COVID-19 testing revenue -13% -14% -5% -4% -3% -6% -1% -1%
Impact of contribution of PPD to Core organic revenue growth (a) 1% N/A N/A N/A N/A N/A N/A N/A
Core organic revenue growth (non-GAAP measure) 14% 6% 2% 1% -4% 1% -3% 0%
(a) Adjustment to include the contribution of PPD to Core organic revenue growth as though the acquisition had occurred on January 1, 2021.
Page 12
Business Segment Information
Page 13
Balance Sheets and Leverage Ratios
Property, plant and equipment, net 8,333 9,280 9,448 9,324 9,282
Acquisition-related intangible assets, net 20,113 17,442 16,670 16,048 15,519
Equity method investments 576 369 489 513 427
Other assets 4,064 3,638 3,510 3,727 3,950
Goodwill 41,924 41,196 44,020 43,843 43,843
Total assets 95,123 97,154 98,726 97,095 98,496
Total liabilities, redeemable noncontrolling interest and equity 95,123 97,154 98,726 97,095 98,496
Leverage Ratios
Total debt / TTM EBITDA 2.8X 2.9X 3.4X 3.4X 3.4X
Effect of adjusted items -0.1X 0.0X -0.2X -0.1X -0.1X
Total debt / adjusted TTM EBITDA 2.7X 2.9X 3.2X 3.3X 3.3X
Page 14
Debt
Effective
Interest Rate at Maturity
(Dollars in millions) 6/29/24 Date 12/31/2021 12/31/2022 12/31/2023 3/30/2024 6/29/2024
Short-term
0.75% Senior Notes (euro denominated) 0.92% 9/12/2024 0 0 1,102 1,078 1,071
1.215% Senior Notes 1.42% 10/18/2024 0 0 2,496 2,497 2,498
0.125% Senior Notes (euro denominated) 0.40% 3/1/2025 0 0 0 861 856
2.00% Senior Notes (euro denominated) 2.09% 4/15/2025 0 0 0 0 685
Commercial paper 2,522 310 0 0 0
Other, including finance lease liabilities 15 5,269 11 15 11
Total short-term 2,537 5,579 3,609 4,451 5,121
Long-term
0.125% Senior Notes (euro denominated) 3/1/2025 902 851 880 0 0
2.00% Senior Notes (euro denominated) 4/15/2025 725 683 706 690 0
0.853% Senior Notes (yen denominated) 1.05% 10/20/2025 0 169 158 147 138
0.000% Senior Notes (euro denominated) 0.15% 11/18/2025 621 586 605 592 588
3.20% Senior Notes (euro denominated) 3.38% 1/21/2026 0 533 550 538 534
1.40% Senior Notes (euro denominated) 1.52% 1/23/2026 792 746 771 754 748
4.953% Senior Notes 5.19% 8/10/2026 0 0 597 597 597
5.00% Senior Notes 5.26% 12/5/2026 0 0 993 994 994
1.45% Senior Notes (euro denominated) 1.65% 3/16/2027 563 531 549 536 533
1.75% Senior Notes (euro denominated) 1.96% 4/15/2027 675 637 658 643 639
1.054% Senior Notes (yen denominated) 1.18% 10/20/2027 0 219 204 190 179
4.80% Senior Notes 5.00% 11/21/2027 0 595 596 596 596
0.50% Senior Notes (euro denominated) 0.76% 3/1/2028 899 848 876 857 851
1.6525% Senior Notes (Swiss franc denominated) 1.80% 3/7/2028 0 0 0 364 365
0.77% Senior Notes (yen denominated) 0.90% 9/6/2028 0 0 204 191 179
1.375% Senior Notes (euro denominated) 1.46% 9/12/2028 679 639 660 645 640
1.75% Senior Notes 1.89% 10/15/2028 694 695 696 696 696
5.00% Senior Notes 5.24% 1/31/2029 0 0 989 990 990
1.95% Senior Notes (euro denominated) 2.07% 7/24/2029 789 743 767 750 745
2.60% Senior Notes 2.74% 10/1/2029 893 894 894 895 895
1.279% Senior Notes (yen denominated) 1.44% 10/19/2029 0 36 33 31 29
4.977% Senior Notes 5.12% 8/10/2030 0 0 744 744 744
0.80% Senior Notes (euro denominated) 0.88% 10/18/2030 1,975 1,861 1,920 1,877 1,864
Page 15
Debt
Effective
Interest Rate at Maturity
(Dollars in millions) 6/29/24 Date 12/31/2021 12/31/2022 12/31/2023 3/30/2024 6/29/2024
0.875% Senior Notes (euro denominated) 1.13% 10/1/2031 1,011 953 984 962 956
2.00% Senior Notes 2.23% 10/15/2031 1,176 1,178 1,181 1,181 1,182
1.8401% Senior Notes (Swiss franc denominated) 1.92% 3/8/2032 0 0 0 458 459
2.375% Senior Notes (euro denominated) 2.54% 4/15/2032 672 633 654 639 635
1.49% Senior Notes (yen denominated) 1.60% 10/20/2032 0 48 44 41 39
4.95% Senior Notes 5.09% 11/21/2032 0 594 594 594 594
5.086% Senior Notes 5.20% 8/10/2033 0 0 991 992 992
1.125% Senior Notes (euro denominated) 1.20% 10/18/2033 1,690 1,592 1,643 1,606 1,595
5.20% Senior Notes 5.34% 1/31/2034 0 0 495 495 495
3.65% Senior Notes (euro denominated) 3.76% 11/21/2034 0 795 820 802 796
1.50% Senior Notes (yen denominated) 1.58% 9/6/2035 0 0 151 141 133
2.0375% Senior Notes (Swiss franc denominated) 2.10% 3/7/2036 0 0 0 358 359
2.875% Senior Notes (euro denominated) 2.94% 7/24/2037 789 743 767 750 744
1.50% Senior Notes (euro denominated) 1.73% 10/1/2039 1,014 955 985 963 956
2.80% Senior Notes 2.90% 10/15/2041 1,181 1,182 1,183 1,183 1,183
1.625% Senior Notes (euro denominated) 1.77% 10/18/2041 1,385 1,305 1,347 1,317 1,308
2.069% Senior Notes (yen denominated) 2.13% 10/20/2042 0 110 103 96 90
5.404% Senior Notes 5.50% 8/10/2043 0 0 593 593 593
2.02% Senior Notes (yen denominated) 2.06% 9/6/2043 0 0 204 190 179
5.30% Senior Notes 5.37% 2/1/2044 396 396 396 396 397
4.10% Senior Notes 4.23% 8/15/2047 734 735 735 735 735
1.875% Senior Notes (euro denominated) 1.98% 10/1/2049 1,112 1,047 1,080 1,056 1,048
2.00% Senior Notes (euro denominated) 2.06% 10/18/2051 840 791 816 797 792
2.382% Senior Notes (yen denominated) 2.43% 10/18/2052 0 252 234 218 205
Other, including finance lease liabilities 10,126 4,334 258 275 270
Total long-term 32,333 28,909 31,308 31,157 30,284
Total debt 34,870 34,488 34,917 35,608 35,404
Total cash and cash equivalents 4,477 8,524 8,077 5,499 7,073
Short-term investments 16 — 3 1,751 1,750
Net debt 30,377 25,964 26,837 28,358 26,582
Page 16
2021 - 2024 Notable Acquisitions
2024
July 10 Olink Leading provider of solutions for advanced proteomics discovery and development LSS $170
2023
Leading provider of regulatory-grade, real-world evidence for approved medical treatments and
August 14 CorEvitas LPBS $92
therapies
January 3 The Binding Site Group Leading provider of oncology testing for detection and monitoring of multiple myeloma SDS £200 (b)
2021
December 30 PeproTech Inc. Leading developer and manufacturer of recombinant proteins LSS $100 (c)
December 8 PPD, Inc. Global clinical research and laboratory services provider LPBS $4,680
September 30 Lengnau biologics manufacturing facility State-of-the-art biologics manufacturing facility LPBS N/A (d)
February 25 Mesa Biotech, Inc. Point-of-care molecular diagnostics provider LSS $70
January 15 European viral vector business Leading provider of contract viral vector manufacturing services for vaccines and therapies LPBS €80
(a) Approximate revenue from prior full year reporting period as of the announcement date.
(b) Calendar year ended December 31, 2022.
(c) Fiscal year ended December 31, 2021.
(d) Assumed operating responsibility from customer.
Page 17
Capital Deployment
Share buybacks
2021 2022 2023 Q1-2024 Q2-2024
Average price paid per share $487.73 $569.47 $574.47 $543.17 $0.00
Dividends paid
Future declarations of dividends are subject to board approval and may be adjusted as business needs or market conditions change.
Page 18
Fiscal Calendar
1 2 3 4 5 6 1 31 1 2 3 4 5 6 14 30 1 2 3 4 5 6 27 29 30 1 2 3 4 5 40
5 14 15 16 17 18 19 20 3 5 14 15 16 17 18 19 20 16 5 14 15 16 17 18 19 20 29 5 13 14 15 16 17 18 19 42
5
Weeks 21 22 23 24 25 26 27 4 Weeks 21 22 23 24 25 26 27 17 Weeks 21 22 23 24 25 26 27 30 Weeks 20 21 22 23 24 25 26 43
28 29 30 31 1 2 3 5 28 29 30 1 2 3 4 18 28 29 30 31 1 2 3 31 27 28 29 30 31 1 2 44
4 5 6 7 8 9 10 6 5 6 7 8 9 10 11 19 4 5 6 7 8 9 10 32 3 4 5 6 7 8 9 45
4 18 19 20 21 22 23 24 8 4 19 20 21 22 23 24 25 21 4 18 19 20 21 22 23 24 34 4 17 18 19 20 21 22 23 47
3 4 5 6 7 8 9 10 2 3 4 5 6 7 8 23 1 2 3 4 5 6 7 36 1 2 3 4 5 6 7 49
4 17 18 19 20 21 22 23 12 4 16 17 18 19 20 21 22 25 4 15 16 17 18 19 20 21 38 4 15 16 17 18 19 20 21 51
4
Weeks 24 25 26 27 28 29 30 13 Weeks 23 24 25 26 27 28 29 26 Weeks 22 23 24 25 26 27 28 39 Weeks 22 23 24 25 26 27 28 52
29 30 31
CHANGE IN DAYS VERSUS PRIOR YEAR 0 CHANGE IN DAYS VERSUS PRIOR YEAR 0 CHANGE IN DAYS VERSUS PRIOR YEAR 0 CHANGE IN DAYS VERSUS PRIOR YEAR +2
Page 19